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A versatile bioelectronic interface programmed for hormone sensing

Author

Listed:
  • Preetam Guha Ray

    (ETH Zurich, Department of Biosystems Science and Engineering)

  • Debasis Maity

    (ETH Zurich, Department of Biosystems Science and Engineering)

  • Jinbo Huang

    (ETH Zurich, Department of Biosystems Science and Engineering)

  • Henryk Zulewski

    (ETH Zurich, Department of Biosystems Science and Engineering
    University Hospital Basel
    Stadtspital Triemli)

  • Martin Fussenegger

    (ETH Zurich, Department of Biosystems Science and Engineering
    University of Basel)

Abstract

Precision medicine requires smart, ultrasensitive, real-time profiling of bio-analytes using interconnected miniaturized devices to achieve individually optimized healthcare. Here, we report a versatile bioelectronic interface (VIBE) that senses signaling-cascade-guided receptor-ligand interactions via an electronic interface. We show that VIBE offers a low detection limit down to sub-nanomolar range characterised by an output current that decreases significantly, leading to precise profiling of these peptide hormones throughout the physiologically relevant concentration ranges. In a proof-of-concept application, we demonstrate that the VIBE platform differentiates insulin and GLP-1 levels in serum samples of wild-type mice from type-1 and type-2 diabetic mice. Evaluation of human serum samples shows that the bioelectronic device can differentiate between samples from different individuals and report differences in their metabolic states. As the target analyte can be changed simply by introducing engineered cells overexpressing the appropriate receptor, the VIBE interface has many potential applications for point-of-care diagnostics and personalized medicine via the internet of things.

Suggested Citation

  • Preetam Guha Ray & Debasis Maity & Jinbo Huang & Henryk Zulewski & Martin Fussenegger, 2023. "A versatile bioelectronic interface programmed for hormone sensing," Nature Communications, Nature, vol. 14(1), pages 1-15, December.
    • Handle: RePEc:nat:natcom:v:14:y:2023:i:1:d:10.1038_s41467-023-39015-1
    DOI: 10.1038/s41467-023-39015-1
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    References listed on IDEAS

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    1. Dominic J. Withers & Julio Sanchez Gutierrez & Heather Towery & Deborah J. Burks & Jian-Ming Ren & Stephen Previs & Yitao Zhang & Dolores Bernal & Sebastian Pons & Gerald I. Shulman & Susan Bonner-Wei, 1998. "Disruption of IRS-2 causes type 2 diabetes in mice," Nature, Nature, vol. 391(6670), pages 900-904, February.
    2. Maysam Mansouri & Marie-Didiée Hussherr & Tobias Strittmatter & Peter Buchmann & Shuai Xue & Gieri Camenisch & Martin Fussenegger, 2021. "Smart-watch-programmed green-light-operated percutaneous control of therapeutic transgenes," Nature Communications, Nature, vol. 12(1), pages 1-10, December.
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