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Lack of Association between Insulin Receptor Substrate2 rs1805097 Polymorphism and the Risk of Colorectal and Breast Cancer: A Meta-Analysis

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  • Yue Hu
  • Min Zhou
  • Kai Zhang
  • Xiangquan Kong
  • Xiaoyan Hu
  • Kang Li
  • Li Liu

Abstract

Background: Insulin receptor substrate-2 (IRS-2), a signaling adaptor protein, was involved in two cancer-related pathways (the phosphatidylinositol 3′-kinase (PI3K) and the extracellular signal-regulated kinase (ERK) pathways). Several studies have evaluated the association between IRS2 rs1805097 (G>A) polymorphisms and the risk of colorectal and breast cancer. However, the results were inconsistent. Methodology/Principal Findings: A meta-analysis of seven published case-control studies (4 studies with 4798 cases and 5478 controls for colorectal cancer and 3 studies with 2108 cases and 2507 controls for breast cancer) were conducted to assess the strength of association using crude odd ratios (ORs) with 95% confidence intervals (CIs). For colorectal cancer, no obvious associations were found for all genetic models (homozygote comparison OR = 0.96, 95%CI 0.85–1.08, Pheterogeneity = 0.97; heterozygote comparison: OR = 0.91, 95%CI 0.73–1.13, Pheterogeneity

Suggested Citation

  • Yue Hu & Min Zhou & Kai Zhang & Xiangquan Kong & Xiaoyan Hu & Kang Li & Li Liu, 2014. "Lack of Association between Insulin Receptor Substrate2 rs1805097 Polymorphism and the Risk of Colorectal and Breast Cancer: A Meta-Analysis," PLOS ONE, Public Library of Science, vol. 9(1), pages 1-7, January.
    • Handle: RePEc:plo:pone00:0086911
    DOI: 10.1371/journal.pone.0086911
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    1. Dominic J. Withers & Julio Sanchez Gutierrez & Heather Towery & Deborah J. Burks & Jian-Ming Ren & Stephen Previs & Yitao Zhang & Dolores Bernal & Sebastian Pons & Gerald I. Shulman & Susan Bonner-Wei, 1998. "Disruption of IRS-2 causes type 2 diabetes in mice," Nature, Nature, vol. 391(6670), pages 900-904, February.
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