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Smart-watch-programmed green-light-operated percutaneous control of therapeutic transgenes

Author

Listed:
  • Maysam Mansouri

    (ETH Zurich)

  • Marie-Didiée Hussherr

    (ETH Zurich)

  • Tobias Strittmatter

    (ETH Zurich)

  • Peter Buchmann

    (ETH Zurich)

  • Shuai Xue

    (ETH Zurich)

  • Gieri Camenisch

    (ETH Zurich)

  • Martin Fussenegger

    (ETH Zurich
    University of Basel)

Abstract

Wearable smart electronic devices, such as smart watches, are generally equipped with green-light-emitting diodes, which are used for photoplethysmography to monitor a panoply of physical health parameters. Here, we present a traceless, green-light-operated, smart-watch-controlled mammalian gene switch (Glow Control), composed of an engineered membrane-tethered green-light-sensitive cobalamin-binding domain of Thermus thermophilus (TtCBD) CarH protein in combination with a synthetic cytosolic TtCBD-transactivator fusion protein, which manage translocation of TtCBD-transactivator into the nucleus to trigger expression of transgenes upon illumination. We show that Apple-Watch-programmed percutaneous remote control of implanted Glow-controlled engineered human cells can effectively treat experimental type-2 diabetes by producing and releasing human glucagon-like peptide-1 on demand. Directly interfacing wearable smart electronic devices with therapeutic gene expression will advance next-generation personalized therapies by linking biopharmaceutical interventions to the internet of things.

Suggested Citation

  • Maysam Mansouri & Marie-Didiée Hussherr & Tobias Strittmatter & Peter Buchmann & Shuai Xue & Gieri Camenisch & Martin Fussenegger, 2021. "Smart-watch-programmed green-light-operated percutaneous control of therapeutic transgenes," Nature Communications, Nature, vol. 12(1), pages 1-10, December.
    • Handle: RePEc:nat:natcom:v:12:y:2021:i:1:d:10.1038_s41467-021-23572-4
    DOI: 10.1038/s41467-021-23572-4
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    Cited by:

    1. Sally Wang & Chen-Yu Chen & John R. Rzasa & Chen-Yu Tsao & Jinyang Li & Eric VanArsdale & Eunkyoung Kim & Fauziah Rahma Zakaria & Gregory F. Payne & William E. Bentley, 2023. "Redox-enabled electronic interrogation and feedback control of hierarchical and networked biological systems," Nature Communications, Nature, vol. 14(1), pages 1-17, December.
    2. Harshwardhan Poddar & Ronald Rios-Santacruz & Derren J. Heyes & Muralidharan Shanmugam & Adam Brookfield & Linus O. Johannissen & Colin W. Levy & Laura N. Jeffreys & Shaowei Zhang & Michiyo Sakuma & J, 2023. "Redox driven B12-ligand switch drives CarH photoresponse," Nature Communications, Nature, vol. 14(1), pages 1-14, December.
    3. Preetam Guha Ray & Debasis Maity & Jinbo Huang & Henryk Zulewski & Martin Fussenegger, 2023. "A versatile bioelectronic interface programmed for hormone sensing," Nature Communications, Nature, vol. 14(1), pages 1-15, December.
    4. Shaowei Zhang & Laura N. Jeffreys & Harshwardhan Poddar & Yuqi Yu & Chuanyang Liu & Kaylee Patel & Linus O. Johannissen & Lingyun Zhu & Matthew J. Cliff & Cunyu Yan & Giorgio Schirò & Martin Weik & Mi, 2024. "Photocobilins integrate B12 and bilin photochemistry for enzyme control," Nature Communications, Nature, vol. 15(1), pages 1-16, December.

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