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Exploring the Mechanism of Insulin Action, Differential Insulin Sensitivity and Insulin Resistance

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  • Vinod Nikhra

    (Department of Medicine, NDMC Medical College, India)

Abstract

Correlating Altered Insulin Sensitivity and MetS: Insulin is an anabolic hormone and regulates glucose homeostasis and other metabolic processes in various organs. With aging, there occurs an impairment of glucose-stimulated insulin pulse mass, amplitude and rhythmicity due to deterioration of β-cell function and progressive loss of β-cell mass. Further, with aging there occurs a reduction in insulin sensitivity leading to insulin resistance (IR) involving liver, striated muscle, adipose tissue and other organs. At the cellular level, the insulin triggers signaling cascades that regulate cell metabolism, cell proliferation and cell survival.

Suggested Citation

  • Vinod Nikhra, 2019. "Exploring the Mechanism of Insulin Action, Differential Insulin Sensitivity and Insulin Resistance," Current Research in Diabetes & Obesity Journal, Juniper Publishers Inc., vol. 12(2), pages 23-31, October.
    • Handle: RePEc:adp:jcrdoj:v:12:y:2019:i:2:p:23-31
    DOI: 10.19080/CRDOJ.2019.11.555831
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    References listed on IDEAS

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    1. Dominic J. Withers & Julio Sanchez Gutierrez & Heather Towery & Deborah J. Burks & Jian-Ming Ren & Stephen Previs & Yitao Zhang & Dolores Bernal & Sebastian Pons & Gerald I. Shulman & Susan Bonner-Wei, 1998. "Disruption of IRS-2 causes type 2 diabetes in mice," Nature, Nature, vol. 391(6670), pages 900-904, February.
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    More about this item

    Keywords

    juniper publishers; diabetes journals; diabetes impact factor; endocrinology journal; endocrinology impact factor; endocrinology research journal; endocrinology research articles; diabetes open access journals; Obesity Journal; Diabetes & Obesity Journal;
    All these keywords.

    JEL classification:

    • R00 - Urban, Rural, Regional, Real Estate, and Transportation Economics - - General - - - General
    • Z0 - Other Special Topics - - General

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