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Enrichment of minor allele of SNPs and genetic prediction of type 2 diabetes risk in British population

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  • Xiaoyun Lei
  • Shi Huang

Abstract

Type 2 diabetes (T2D) is a complex disorder characterized by high blood sugar, insulin resistance, and relative lack of insulin. The collective effects of genome wide minor alleles of common SNPs, or the minor allele content (MAC) in an individual, have been linked with quantitative variations of complex traits and diseases. Here we studied MAC in T2D using previously published SNP datasets and found higher MAC in cases relative to matched controls. A set of 357 SNPs was found to have the best predictive accuracy in a British population. A weighted risk score calculated by using this set produced an area under the curve (AUC) score of 0.86, which is comparable to risk models built by phenotypic markers. These results identify a novel genetic risk element in T2D susceptibility and provide a potentially useful genetic method to identify individuals with high risk of T2D.

Suggested Citation

  • Xiaoyun Lei & Shi Huang, 2017. "Enrichment of minor allele of SNPs and genetic prediction of type 2 diabetes risk in British population," PLOS ONE, Public Library of Science, vol. 12(11), pages 1-13, November.
    • Handle: RePEc:plo:pone00:0187644
    DOI: 10.1371/journal.pone.0187644
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    1. Dominic J. Withers & Julio Sanchez Gutierrez & Heather Towery & Deborah J. Burks & Jian-Ming Ren & Stephen Previs & Yitao Zhang & Dolores Bernal & Sebastian Pons & Gerald I. Shulman & Susan Bonner-Wei, 1998. "Disruption of IRS-2 causes type 2 diabetes in mice," Nature, Nature, vol. 391(6670), pages 900-904, February.
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