IDEAS home Printed from https://ideas.repec.org/a/nat/natcom/v14y2023i1d10.1038_s41467-023-38156-7.html
   My bibliography  Save this article

Less is more: Antibiotics at the beginning of life

Author

Listed:
  • Martin Stocker

    (Children’s Hospital Lucerne)

  • Claus Klingenberg

    (UiT-The Arctic University of Norway
    University Hospital of North Norway)

  • Lars Navér

    (Karolinska University Hospital
    Karolinska Institutet)

  • Viveka Nordberg

    (Karolinska University Hospital
    Karolinska Institutet)

  • Alberto Berardi

    (Policlinico University Hospital)

  • Salhab el Helou

    (McMaster University, Hamilton Health Sciences)

  • Gerhard Fusch

    (McMaster University, Hamilton Health Sciences)

  • Joseph M. Bliss

    (Warren Alpert Medical School of Brown University)

  • Dirk Lehnick

    (University of Lucerne)

  • Varvara Dimopoulou

    (Lausanne University Hospital and University of Lausanne)

  • Nicholas Guerina

    (Warren Alpert Medical School of Brown University)

  • Joanna Seliga-Siwecka

    (Medical University of Warsaw)

  • Pierre Maton

    (Clinique CHC-Montlegia, groupe santé CHC)

  • Donatienne Lagae

    (CHIREC-Delta Hospital)

  • Judit Mari

    (University of Szeged)

  • Jan Janota

    (Motol University Hospital Prague
    Thomayer University Hospital Prague)

  • Philipp K. A. Agyeman

    (Bern University Hospital, University of Bern)

  • Riccardo Pfister

    (Geneva University Hospitals and Geneva University)

  • Giuseppe Latorre

    (Ecclesiastical General Hospital F. Miulli)

  • Gianfranco Maffei

    (Policlinico Riuniti Foggia)

  • Nichola Laforgia

    (University of Bari)

  • Enikő Mózes

    (Semmelweis University)

  • Ketil Størdal

    (University of Oslo and Oslo University Hospital)

  • Tobias Strunk

    (King Edward Memorial Hospital)

  • Eric Giannoni

    (Lausanne University Hospital and University of Lausanne)

Abstract

Antibiotic exposure at the beginning of life can lead to increased antimicrobial resistance and perturbations of the developing microbiome. Early-life microbiome disruption increases the risks of developing chronic diseases later in life. Fear of missing evolving neonatal sepsis is the key driver for antibiotic overtreatment early in life. Bias (a systemic deviation towards overtreatment) and noise (a random scatter) affect the decision-making process. In this perspective, we advocate for a factual approach quantifying the burden of treatment in relation to the burden of disease balancing antimicrobial stewardship and effective sepsis management.

Suggested Citation

  • Martin Stocker & Claus Klingenberg & Lars Navér & Viveka Nordberg & Alberto Berardi & Salhab el Helou & Gerhard Fusch & Joseph M. Bliss & Dirk Lehnick & Varvara Dimopoulou & Nicholas Guerina & Joanna , 2023. "Less is more: Antibiotics at the beginning of life," Nature Communications, Nature, vol. 14(1), pages 1-9, December.
  • Handle: RePEc:nat:natcom:v:14:y:2023:i:1:d:10.1038_s41467-023-38156-7
    DOI: 10.1038/s41467-023-38156-7
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/s41467-023-38156-7
    File Function: Abstract
    Download Restriction: no

    File URL: https://libkey.io/10.1038/s41467-023-38156-7?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    References listed on IDEAS

    as
    1. Feng Zhu & Yanmei Ju & Wei Wang & Qi Wang & Ruijin Guo & Qingyan Ma & Qiang Sun & Yajuan Fan & Yuying Xie & Zai Yang & Zhuye Jie & Binbin Zhao & Liang Xiao & Lin Yang & Tao Zhang & Junqin Feng & Liyan, 2020. "Metagenome-wide association of gut microbiome features for schizophrenia," Nature Communications, Nature, vol. 11(1), pages 1-10, December.
    2. James Andreoni & Charles Sprenger, 2012. "Risk Preferences Are Not Time Preferences," American Economic Review, American Economic Association, vol. 102(7), pages 3357-3376, December.
    3. Djawad Radjabzadeh & Jos A. Bosch & André G. Uitterlinden & Aeilko H. Zwinderman & M. Arfan Ikram & Joyce B. J. Meurs & Annemarie I. Luik & Max Nieuwdorp & Anja Lok & Cornelia M. Duijn & Robert Kraaij, 2022. "Gut microbiome-wide association study of depressive symptoms," Nature Communications, Nature, vol. 13(1), pages 1-10, December.
    4. Zhuye Jie & Huihua Xia & Shi-Long Zhong & Qiang Feng & Shenghui Li & Suisha Liang & Huanzi Zhong & Zhipeng Liu & Yuan Gao & Hui Zhao & Dongya Zhang & Zheng Su & Zhiwei Fang & Zhou Lan & Junhua Li & Li, 2017. "The gut microbiome in atherosclerotic cardiovascular disease," Nature Communications, Nature, vol. 8(1), pages 1-12, December.
    5. Yifei Zhang & Yanyun Gu & Huahui Ren & Shujie Wang & Huanzi Zhong & Xinjie Zhao & Jing Ma & Xuejiang Gu & Yaoming Xue & Shan Huang & Jialin Yang & Li Chen & Gang Chen & Shen Qu & Jun Liang & Li Qin & , 2020. "Gut microbiome-related effects of berberine and probiotics on type 2 diabetes (the PREMOTE study)," Nature Communications, Nature, vol. 11(1), pages 1-12, December.
    6. Marta Reyman & Marlies A. Houten & Rebecca L. Watson & Mei Ling J. N. Chu & Kayleigh Arp & Wouter J. Waal & Irene Schiering & Frans B. Plötz & Rob J. L. Willems & Willem Schaik & Elisabeth A. M. Sande, 2022. "Effects of early-life antibiotics on the developing infant gut microbiome and resistome: a randomized trial," Nature Communications, Nature, vol. 13(1), pages 1-12, December.
    7. Ilseung Cho & Shingo Yamanishi & Laura Cox & Barbara A. Methé & Jiri Zavadil & Kelvin Li & Zhan Gao & Douglas Mahana & Kartik Raju & Isabel Teitler & Huilin Li & Alexander V. Alekseyenko & Martin J. B, 2012. "Antibiotics in early life alter the murine colonic microbiome and adiposity," Nature, Nature, vol. 488(7413), pages 621-626, August.
    8. Lynne Peeples, 2022. "Lessons from the COVID data wizards," Nature, Nature, vol. 603(7902), pages 564-567, March.
    9. Cabral, Christie & Lucas, Patricia J. & Ingram, Jenny & Hay, Alastair D. & Horwood, Jeremy, 2015. "“It's safer to …” parent consulting and clinician antibiotic prescribing decisions for children with respiratory tract infections: An analysis across four qualitative studies," Social Science & Medicine, Elsevier, vol. 136, pages 156-164.
    Full references (including those not matched with items on IDEAS)

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. Stephen L. Cheung & Agnieszka Tymula & Xueting Wang, 2022. "Present bias for monetary and dietary rewards," Experimental Economics, Springer;Economic Science Association, vol. 25(4), pages 1202-1233, September.
    2. Fischbacher, Urs & Schudy, Simeon & Teyssier, Sabrina, 2021. "Heterogeneous preferences and investments in energy saving measures," Resource and Energy Economics, Elsevier, vol. 63(C).
    3. Achal Dhariwal & Polona Rajar & Gabriela Salvadori & Heidi Aarø Åmdal & Dag Berild & Ola Didrik Saugstad & Drude Fugelseth & Gorm Greisen & Ulf Dahle & Kirsti Haaland & Fernanda Cristina Petersen, 2024. "Prolonged hospitalization signature and early antibiotic effects on the nasopharyngeal resistome in preterm infants," Nature Communications, Nature, vol. 15(1), pages 1-13, December.
    4. Groneck, Max & Ludwig, Alexander & Zimper, Alexander, 2016. "A life-cycle model with ambiguous survival beliefs," Journal of Economic Theory, Elsevier, vol. 162(C), pages 137-180.
    5. Jindrich Matousek & Tomas Havranek & Zuzana Irsova, 2022. "Individual discount rates: a meta-analysis of experimental evidence," Experimental Economics, Springer;Economic Science Association, vol. 25(1), pages 318-358, February.
    6. Alex Imas & Sally Sadoff & Anya Samek, 2017. "Do People Anticipate Loss Aversion?," Management Science, INFORMS, vol. 63(5), pages 1271-1284, May.
    7. Meyer, Andrew G., 2015. "The impacts of elicitation mechanism and reward size on estimated rates of time preference," Journal of Behavioral and Experimental Economics (formerly The Journal of Socio-Economics), Elsevier, vol. 58(C), pages 132-148.
    8. Laurent Denant-Boemont & Enrico Diecidue & Olivier l’Haridon, 2017. "Patience and time consistency in collective decisions," Experimental Economics, Springer;Economic Science Association, vol. 20(1), pages 181-208, March.
    9. Keefer, Philip & Scartascini, Carlos & Vlaicu, Razvan, 2022. "Demand-side determinants of public spending allocations: Voter trust, risk and time preferences," Journal of Public Economics, Elsevier, vol. 206(C).
    10. Lorenzo Casaburi & Jack Willis, 2018. "Time versus State in Insurance: Experimental Evidence from Contract Farming in Kenya," American Economic Review, American Economic Association, vol. 108(12), pages 3778-3813, December.
    11. Yoichi Hizen & Kengo Kurosaka, 2021. "Monetary Costs Versus Opportunity Costs in a Voting Experiment," Working Papers SDES-2021-1, Kochi University of Technology, School of Economics and Management, revised Feb 2021.
    12. Alexander Harin, 2024. "About a “Certain-uncertain†Inconsistency within the Generally Accepted Experimental Procedures of Behavioral Economics," International Journal of Economics and Financial Research, Academic Research Publishing Group, vol. 10(2), pages 17-30, 06-2024.
    13. Lenore Manderson, 2020. "Prescribing, care and resistance: antibiotic use in urban South Africa," Palgrave Communications, Palgrave Macmillan, vol. 7(1), pages 1-10, December.
    14. Wölbert, E.M. & Riedl, A.M., 2013. "Measuring time and risk preferences: Reliability, stability, domain specificity," Research Memorandum 041, Maastricht University, Graduate School of Business and Economics (GSBE).
    15. Stein T. Holden & Dag Einar Sommervoll & Mesfin Tilahun, 2022. "Mental Zooming as Variable Asset Integration in Inter-Temporal Choice," International Journal of Applied Behavioral Economics (IJABE), IGI Global, vol. 11(1), pages 1-21, January.
    16. Anke Gerber & Kirsten I. M. Rohde, 2018. "Weighted temporal utility," Economic Theory, Springer;Society for the Advancement of Economic Theory (SAET), vol. 66(1), pages 187-212, July.
    17. Holden, Stein T. & Tilahun, Mesfin, 2019. "How related are risk preferences and time preferences?," CLTS Working Papers 4/19, Norwegian University of Life Sciences, Centre for Land Tenure Studies, revised 16 Oct 2019.
    18. Holden, Stein T. & Tilahun, Mesfin & Sommervoll, Dag Einar, 2022. "Is diminishing impatience in time-dated risky prospects explained by probability weighting?," CLTS Working Papers 3/22, Norwegian University of Life Sciences, Centre for Land Tenure Studies.
    19. Hanushek, Eric A. & Kinne, Lavinia & Lergetporer, Philipp & Woessmann, Ludger, 2020. "Culture and Student Achievement: The Intertwined Roles of Patience and Risk-Taking," Rationality and Competition Discussion Paper Series 249, CRC TRR 190 Rationality and Competition.
    20. Rodriguez-Lara, Ismael & Ponti, Giovanni, 2017. "Social motives vs social influence: An experiment on interdependent time preferences," Games and Economic Behavior, Elsevier, vol. 105(C), pages 177-194.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:natcom:v:14:y:2023:i:1:d:10.1038_s41467-023-38156-7. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.