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Gut microbiome-wide association study of depressive symptoms

Author

Listed:
  • Djawad Radjabzadeh

    (Erasmus Medical Center Rotterdam)

  • Jos A. Bosch

    (University of Amsterdam
    Amsterdam University Medical Centers)

  • André G. Uitterlinden

    (Erasmus Medical Center Rotterdam
    Erasmus MC University Medical Center Rotterdam)

  • Aeilko H. Zwinderman

    (Amsterdam University Medical Centers)

  • M. Arfan Ikram

    (Erasmus MC University Medical Center Rotterdam)

  • Joyce B. J. Meurs

    (Erasmus Medical Center Rotterdam)

  • Annemarie I. Luik

    (Erasmus MC University Medical Center Rotterdam)

  • Max Nieuwdorp

    (Amsterdam University Medical Centers, Location AMC)

  • Anja Lok

    (Location AMC)

  • Cornelia M. Duijn

    (Erasmus MC University Medical Center Rotterdam
    Oxford University)

  • Robert Kraaij

    (Erasmus Medical Center Rotterdam)

  • Najaf Amin

    (Erasmus MC University Medical Center Rotterdam
    Oxford University)

Abstract

Depression is one of the most poorly understood diseases due to its elusive pathogenesis. There is an urgency to identify molecular and biological mechanisms underlying depression and the gut microbiome is a novel area of interest. Here we investigate the relation of fecal microbiome diversity and composition with depressive symptoms in 1,054 participants from the Rotterdam Study cohort and validate these findings in the Amsterdam HELIUS cohort in 1,539 subjects. We identify association of thirteen microbial taxa, including genera Eggerthella, Subdoligranulum, Coprococcus, Sellimonas, Lachnoclostridium, Hungatella, Ruminococcaceae (UCG002, UCG003 and UCG005), LachnospiraceaeUCG001, Eubacterium ventriosum and Ruminococcusgauvreauiigroup, and family Ruminococcaceae with depressive symptoms. These bacteria are known to be involved in the synthesis of glutamate, butyrate, serotonin and gamma amino butyric acid (GABA), which are key neurotransmitters for depression. Our study suggests that the gut microbiome composition may play a key role in depression.

Suggested Citation

  • Djawad Radjabzadeh & Jos A. Bosch & André G. Uitterlinden & Aeilko H. Zwinderman & M. Arfan Ikram & Joyce B. J. Meurs & Annemarie I. Luik & Max Nieuwdorp & Anja Lok & Cornelia M. Duijn & Robert Kraaij, 2022. "Gut microbiome-wide association study of depressive symptoms," Nature Communications, Nature, vol. 13(1), pages 1-10, December.
    • Handle: RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-022-34502-3
    DOI: 10.1038/s41467-022-34502-3
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    References listed on IDEAS

    as
    1. Stephen Nayfach & Zhou Jason Shi & Rekha Seshadri & Katherine S. Pollard & Nikos C. Kyrpides, 2019. "New insights from uncultivated genomes of the global human gut microbiome," Nature, Nature, vol. 568(7753), pages 505-510, April.
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    1. Martin Stocker & Claus Klingenberg & Lars Navér & Viveka Nordberg & Alberto Berardi & Salhab el Helou & Gerhard Fusch & Joseph M. Bliss & Dirk Lehnick & Varvara Dimopoulou & Nicholas Guerina & Joanna , 2023. "Less is more: Antibiotics at the beginning of life," Nature Communications, Nature, vol. 14(1), pages 1-9, December.

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