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Antibiotics in early life alter the murine colonic microbiome and adiposity

Author

Listed:
  • Ilseung Cho

    (New York University School of Medicine
    Medical Service, VA New York Harbor Healthcare System)

  • Shingo Yamanishi

    (New York University School of Medicine)

  • Laura Cox

    (New York University School of Medicine)

  • Barbara A. Methé

    (J. Craig Venter Institute)

  • Jiri Zavadil

    (New York University School of Medicine
    Center for Health Informatics and Bioinformatics, New York University School of Medicine)

  • Kelvin Li

    (J. Craig Venter Institute)

  • Zhan Gao

    (New York University School of Medicine)

  • Douglas Mahana

    (New York University School of Medicine)

  • Kartik Raju

    (New York University School of Medicine)

  • Isabel Teitler

    (New York University School of Medicine)

  • Huilin Li

    (New York University School of Medicine)

  • Alexander V. Alekseyenko

    (New York University School of Medicine
    Center for Health Informatics and Bioinformatics, New York University School of Medicine)

  • Martin J. Blaser

    (New York University School of Medicine
    Medical Service, VA New York Harbor Healthcare System
    New York University School of Medicine)

Abstract

Antibiotics administered in low doses have been widely used as growth promoters in the agricultural industry since the 1950s, yet the mechanisms for this effect are unclear. Because antimicrobial agents of different classes and varying activity are effective across several vertebrate species, we proposed that such subtherapeutic administration alters the population structure of the gut microbiome as well as its metabolic capabilities. We generated a model of adiposity by giving subtherapeutic antibiotic therapy to young mice and evaluated changes in the composition and capabilities of the gut microbiome. Administration of subtherapeutic antibiotic therapy increased adiposity in young mice and increased hormone levels related to metabolism. We observed substantial taxonomic changes in the microbiome, changes in copies of key genes involved in the metabolism of carbohydrates to short-chain fatty acids, increases in colonic short-chain fatty acid levels, and alterations in the regulation of hepatic metabolism of lipids and cholesterol. In this model, we demonstrate the alteration of early-life murine metabolic homeostasis through antibiotic manipulation.

Suggested Citation

  • Ilseung Cho & Shingo Yamanishi & Laura Cox & Barbara A. Methé & Jiri Zavadil & Kelvin Li & Zhan Gao & Douglas Mahana & Kartik Raju & Isabel Teitler & Huilin Li & Alexander V. Alekseyenko & Martin J. B, 2012. "Antibiotics in early life alter the murine colonic microbiome and adiposity," Nature, Nature, vol. 488(7413), pages 621-626, August.
    • Handle: RePEc:nat:nature:v:488:y:2012:i:7413:d:10.1038_nature11400
    DOI: 10.1038/nature11400
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    Cited by:

    1. Toni Meier & Karolin Senftleben & Peter Deumelandt & Olaf Christen & Katja Riedel & Martin Langer, 2015. "Healthcare Costs Associated with an Adequate Intake of Sugars, Salt and Saturated Fat in Germany: A Health Econometrical Analysis," PLOS ONE, Public Library of Science, vol. 10(9), pages 1-21, September.
    2. EM Ahmed & Marwa Al-Moghazy, 2020. "Microbial Endocrinology- Interaction of the Microbial Hormones with the Host," Biomedical Journal of Scientific & Technical Research, Biomedical Research Network+, LLC, vol. 24(2), pages 18052-18054, January.
    3. Amanda H Pendegraft & Boyi Guo & Nengjun Yi, 2019. "Bayesian hierarchical negative binomial models for multivariable analyses with applications to human microbiome count data," PLOS ONE, Public Library of Science, vol. 14(8), pages 1-23, August.
    4. Brandon Hickman & Anne Salonen & Alise J. Ponsero & Roosa Jokela & Kaija-Leena Kolho & Willem M. Vos & Katri Korpela, 2024. "Gut microbiota wellbeing index predicts overall health in a cohort of 1000 infants," Nature Communications, Nature, vol. 15(1), pages 1-15, December.
    5. Jiyuan Hu & Chan Wang & Martin J. Blaser & Huilin Li, 2022. "Joint modeling of zero‐inflated longitudinal proportions and time‐to‐event data with application to a gut microbiome study," Biometrics, The International Biometric Society, vol. 78(4), pages 1686-1698, December.
    6. Natsuko Tabata & Mai Tsukada & Kozue Kubo & Yuri Inoue & Reiko Miroku & Fumihiko Odashima & Koichiro Shiratori & Takashi Sekiya & Shintaro Sengoku & Hideaki Shiroyama & Hiromichi Kimura, 2022. "Living Lab for Citizens’ Wellness: A Case of Maintaining and Improving a Healthy Diet under the COVID-19 Pandemic," IJERPH, MDPI, vol. 19(3), pages 1-17, January.
    7. Monica Vera-Lise Tulstrup & Ellen Gerd Christensen & Vera Carvalho & Caroline Linninge & Siv Ahrné & Ole Højberg & Tine Rask Licht & Martin Iain Bahl, 2015. "Antibiotic Treatment Affects Intestinal Permeability and Gut Microbial Composition in Wistar Rats Dependent on Antibiotic Class," PLOS ONE, Public Library of Science, vol. 10(12), pages 1-17, December.
    8. Kerstin Thriene & Karin B. Michels, 2023. "Human Gut Microbiota Plasticity throughout the Life Course," IJERPH, MDPI, vol. 20(2), pages 1-14, January.
    9. Martin Stocker & Claus Klingenberg & Lars Navér & Viveka Nordberg & Alberto Berardi & Salhab el Helou & Gerhard Fusch & Joseph M. Bliss & Dirk Lehnick & Varvara Dimopoulou & Nicholas Guerina & Joanna , 2023. "Less is more: Antibiotics at the beginning of life," Nature Communications, Nature, vol. 14(1), pages 1-9, December.
    10. Adekunle G. Fakunle & Babatunde Olusola & Nkosana Jafta & Adedayo Faneye & Dick Heederik & Lidwien A.M. Smit & Rajen N. Naidoo, 2020. "Home Assessment of Indoor Microbiome (HAIM) in Relation to Lower Respiratory Tract Infections among Under-Five Children in Ibadan, Nigeria: The Study Protocol," IJERPH, MDPI, vol. 17(6), pages 1-16, March.

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