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Identification of three bacterial species associated with increased appendicular lean mass: the HUNT study

Author

Listed:
  • Louise Grahnemo

    (University of Gothenburg)

  • Maria Nethander

    (University of Gothenburg
    University of Gothenburg)

  • Eivind Coward

    (NTNU, Norwegian University of Science and Technology)

  • Maiken Elvestad Gabrielsen

    (NTNU, Norwegian University of Science and Technology)

  • Satya Sree

    (Bio-Me, Oslo Science Park)

  • Jean-Marc Billod

    (Bio-Me, Oslo Science Park)

  • Klara Sjögren

    (University of Gothenburg)

  • Lars Engstrand

    (Tumor and Cell Biology, Centre for Translational Microbiome Research, Karolinska Institutet, Karolinska Hospital, Biomedicum A8)

  • Koen F. Dekkers

    (Uppsala University)

  • Tove Fall

    (Uppsala University)

  • Arnulf Langhammer

    (NTNU, Norwegian University of Science and Technology
    Levanger Hospital, Nord-Trøndelag Hospital Trust)

  • Kristian Hveem

    (NTNU, Norwegian University of Science and Technology
    NTNU, Norwegian University of Science and Technology
    Levanger Hospital, Nord-Trøndelag Hospital Trust)

  • Claes Ohlsson

    (University of Gothenburg
    Sahlgrenska University Hospital, Department of Drug Treatment)

Abstract

Appendicular lean mass (ALM) associates with mobility and bone mineral density (BMD). While associations between gut microbiota composition and ALM have been reported, previous studies rely on relatively small sample sizes. Here, we determine the associations between prevalent gut microbes and ALM in large discovery and replication cohorts with information on relevant confounders within the population-based Norwegian HUNT cohort (n = 5196, including women and men). We show that the presence of three bacterial species – Coprococcus comes, Dorea longicatena, and Eubacterium ventriosum – are reproducibly associated with higher ALM. When combined into an anabolic species count, participants with all three anabolic species have 0.80 kg higher ALM than those without any. In an exploratory analysis, the anabolic species count is positively associated with femoral neck and total hip BMD. We conclude that the anabolic species count may be used as a marker of ALM and BMD. The therapeutic potential of these anabolic species to prevent sarcopenia and osteoporosis needs to be determined.

Suggested Citation

  • Louise Grahnemo & Maria Nethander & Eivind Coward & Maiken Elvestad Gabrielsen & Satya Sree & Jean-Marc Billod & Klara Sjögren & Lars Engstrand & Koen F. Dekkers & Tove Fall & Arnulf Langhammer & Kris, 2023. "Identification of three bacterial species associated with increased appendicular lean mass: the HUNT study," Nature Communications, Nature, vol. 14(1), pages 1-9, December.
  • Handle: RePEc:nat:natcom:v:14:y:2023:i:1:d:10.1038_s41467-023-37978-9
    DOI: 10.1038/s41467-023-37978-9
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    References listed on IDEAS

    as
    1. Matthew A. Jackson & Serena Verdi & Maria-Emanuela Maxan & Cheol Min Shin & Jonas Zierer & Ruth C. E. Bowyer & Tiphaine Martin & Frances M. K. Williams & Cristina Menni & Jordana T. Bell & Tim D. Spec, 2018. "Gut microbiota associations with common diseases and prescription medications in a population-based cohort," Nature Communications, Nature, vol. 9(1), pages 1-8, December.
    2. Koen F. Dekkers & Sergi Sayols-Baixeras & Gabriel Baldanzi & Christoph Nowak & Ulf Hammar & Diem Nguyen & Georgios Varotsis & Louise Brunkwall & Nynne Nielsen & Aron C. Eklund & Jacob Bak Holm & H. Bj, 2022. "An online atlas of human plasma metabolite signatures of gut microbiome composition," Nature Communications, Nature, vol. 13(1), pages 1-12, December.
    3. M. Carola Zillikens & Serkalem Demissie & Yi-Hsiang Hsu & Laura M. Yerges-Armstrong & Wen-Chi Chou & Lisette Stolk & Gregory Livshits & Linda Broer & Toby Johnson & Daniel L. Koller & Zoltán Kutalik &, 2017. "Erratum: Large meta-analysis of genome-wide association studies identifies five loci for lean body mass," Nature Communications, Nature, vol. 8(1), pages 1-4, December.
    4. Ivan Vujkovic-Cvijin & Jack Sklar & Lingjing Jiang & Loki Natarajan & Rob Knight & Yasmine Belkaid, 2020. "Host variables confound gut microbiota studies of human disease," Nature, Nature, vol. 587(7834), pages 448-454, November.
    5. M. Carola Zillikens & Serkalem Demissie & Yi-Hsiang Hsu & Laura M. Yerges-Armstrong & Wen-Chi Chou & Lisette Stolk & Gregory Livshits & Linda Broer & Toby Johnson & Daniel L. Koller & Zoltán Kutalik &, 2017. "Large meta-analysis of genome-wide association studies identifies five loci for lean body mass," Nature Communications, Nature, vol. 8(1), pages 1-13, December.
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