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Large meta-analysis of genome-wide association studies identifies five loci for lean body mass

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Listed:
  • M. Carola Zillikens

    (Erasmus MC
    Netherlands Genomics Initiative (NGI)-sponsored Netherlands Consortium for Healthy Aging (NCHA))

  • Serkalem Demissie

    (Boston University School of Public Health)

  • Yi-Hsiang Hsu

    (Hebrew SeniorLife, Institute for Aging Research
    Harvard Medical School
    Harvard School of Public Health)

  • Laura M. Yerges-Armstrong

    (University of Maryland School of Medicine)

  • Wen-Chi Chou

    (Hebrew SeniorLife, Institute for Aging Research
    Harvard Medical School
    Broad Institute)

  • Lisette Stolk

    (Erasmus MC
    Netherlands Genomics Initiative (NGI)-sponsored Netherlands Consortium for Healthy Aging (NCHA))

  • Gregory Livshits

    (Tel Aviv University
    St Thomas’ Campus)

  • Linda Broer

    (Erasmus MC)

  • Toby Johnson

    (University of Lausanne
    Swiss Institute of Bioinformatics
    University Institute for Social and Preventive Medicine)

  • Daniel L. Koller

    (Indiana University School of Medicine)

  • Zoltán Kutalik

    (University of Lausanne
    Swiss Institute of Bioinformatics
    University Institute for Social and Preventive Medicine)

  • Jian’an Luan

    (Cambridge Biomedical Campus)

  • Ida Malkin

    (Tel Aviv University)

  • Janina S. Ried

    (Helmholtz Zentrum München – German Research Center for Environmental Health)

  • Albert V. Smith

    (Icelandic Heart Association
    University of Iceland)

  • Gudmar Thorleifsson

    (deCODE Genetics)

  • Liesbeth Vandenput

    (University of Gothenburg)

  • Jing Hua Zhao

    (Cambridge Biomedical Campus)

  • Weihua Zhang

    (Imperial College
    Ealing Hospital NHS Trust)

  • Ali Aghdassi

    (University of Greifswald)

  • Kristina Åkesson

    (Lund University
    Skåne University Hospital)

  • Najaf Amin

    (Erasmus MC)

  • Leslie J. Baier

    (National Institute of Diabetes and Digestive and Kidney Diseases, NIH)

  • Inês Barroso

    (Wellcome Trust Genome Campus
    Addenbrooke’s Hospital
    University of Cambridge Metabolic Research Laboratories)

  • David A. Bennett

    (Rush University Medical Center)

  • Lars Bertram

    (University of Lübeck
    Imperial College London)

  • Rainer Biffar

    (University of Greifswald)

  • Murielle Bochud

    (University Institute for Social and Preventive Medicine)

  • Michael Boehnke

    (University of Michigan)

  • Ingrid B. Borecki

    (Washington University School of Medicine
    Washington University School of Medicine)

  • Aron S. Buchman

    (Rush University Medical Center)

  • Liisa Byberg

    (Uppsala University)

  • Harry Campbell

    (University of Edinburgh)

  • Natalia Campos Obanda

    (Erasmus MC)

  • Jane A. Cauley

    (University of Pittsburgh)

  • Peggy M. Cawthon

    (California Pacific Medical Center Research Institute)

  • Henna Cederberg

    (University of Eastern Finland and Kuopio University Hospital)

  • Zhao Chen

    (University of Arizona)

  • Nam H. Cho

    (Ajou University School of Medicine)

  • Hyung Jin Choi

    (Seoul National University College of Medicine
    Chungbuk National University Hospital)

  • Melina Claussnitzer

    (Hebrew SeniorLife, Institute for Aging Research
    Harvard Medical School
    Broad Institute
    Computer Science and Artificial Intelligence Laboratory, MIT)

  • Francis Collins

    (National Human Genome Research Institute)

  • Steven R. Cummings

    (California Pacific Medical Center Research Institute)

  • Philip L. Jager

    (Harvard Medical School
    Brigham and Women’s Hospital
    Broad Institute)

  • Ilja Demuth

    (Charité – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health
    Charité – Universitätsmedizin Berlin)

  • Rosalie A. M. Dhonukshe-Rutten

    (Wageningen University, PO Box 17)

  • Luda Diatchenko

    (McGill University
    University of North Carolina at Chapel Hill)

  • Gudny Eiriksdottir

    (Icelandic Heart Association)

  • Anke W. Enneman

    (Erasmus MC)

  • Mike Erdos

    (National Human Genome Research Institute)

  • Johan G. Eriksson

    (University of Helsinki
    Helsinki University Central Hospital
    Folkhalsan Research Centre
    Vasa Central Hospital)

  • Joel Eriksson

    (University of Gothenburg)

  • Karol Estrada

    (Erasmus MC
    Erasmus MC)

  • Daniel S. Evans

    (California Pacific Medical Center Research Institute)

  • Mary F. Feitosa

    (Washington University School of Medicine)

  • Mao Fu

    (University of Maryland School of Medicine)

  • Melissa Garcia

    (National Institute for Aging)

  • Christian Gieger

    (Helmholtz Zentrum München – German Research Center for Environmental Health
    Helmholtz Zentrum München - German Research Center for Environmental Health
    Helmholtz Zentrum München - German Research Center for Environmental Health)

  • Thomas Girke

    (University of California
    University of California)

  • Nicole L. Glazer

    (Boston University School of Medicine and Public Health)

  • Harald Grallert

    (Helmholtz Zentrum München – German Research Center for Environmental Health
    Helmholtz Zentrum München - German Research Center for Environmental Health
    University of California
    German Center for Diabetes Research (DZD))

  • Jagvir Grewal

    (Ealing Hospital NHS Trust
    Imperial College London)

  • Bok-Ghee Han

    (Osong Health Technology Administration Complex)

  • Robert L. Hanson

    (National Institute of Diabetes and Digestive and Kidney Diseases, NIH)

  • Caroline Hayward

    (University of Edinburgh)

  • Albert Hofman

    (Netherlands Genomics Initiative (NGI)-sponsored Netherlands Consortium for Healthy Aging (NCHA)
    Erasmus MC)

  • Eric P. Hoffman

    (SUNY Binghamton)

  • Georg Homuth

    (University of Greifswald)

  • Wen-Chi Hsueh

    (National Institute of Diabetes and Digestive and Kidney Diseases, NIH)

  • Monica J. Hubal

    (George Washington University
    Children’s National Medical Center)

  • Alan Hubbard

    (University of California)

  • Kim M. Huffman

    (Duke University School of Medicine)

  • Lise B. Husted

    (Aarhus University Hospital)

  • Thomas Illig

    (Helmholtz Zentrum München - German Research Center for Environmental Health
    Hannover Medical School
    Hannover Medical School)

  • Erik Ingelsson

    (Uppsala University
    Stanford University School of Medicine)

  • Till Ittermann

    (University of Greifswald)

  • John-Olov Jansson

    (University of Gothenburg)

  • Joanne M. Jordan

    (University of North Carolina at Chapel Hill)

  • Antti Jula

    (National Institute for Health and Welfare)

  • Magnus Karlsson

    (Lund University, Skåne University Hospital SUS)

  • Kay-Tee Khaw

    (University of Cambridge)

  • Tuomas O. Kilpeläinen

    (Cambridge Biomedical Campus
    University of Copenhagen
    Icahn School of Medicine at Mount Sinai)

  • Norman Klopp

    (Helmholtz Zentrum München - German Research Center for Environmental Health
    Hannover Medical School)

  • Jacqueline S. L. Kloth

    (Erasmus MC)

  • Heikki A. Koistinen

    (University of Helsinki and Helsinki University Central Hospital
    University of Helsinki and Helsinki University Central Hospital
    National Institute for Health and Welfare
    Minerva Foundation Institute for Medical Research)

  • William E. Kraus

    (Duke University School of Medicine)

  • Stephen Kritchevsky

    (Wake Forest School of Medicine)

  • Teemu Kuulasmaa

    (University of Eastern Finland and Kuopio University Hospital)

  • Johanna Kuusisto

    (University of Eastern Finland and Kuopio University Hospital)

  • Markku Laakso

    (University of Eastern Finland and Kuopio University Hospital)

  • Jari Lahti

    (University of Helsinki)

  • Thomas Lang

    (University of California San Francisco)

  • Bente L. Langdahl

    (Aarhus University Hospital)

  • Lenore J. Launer

    (National Institute for Aging)

  • Jong-Young Lee

    (Osong Health Technology Administration Complex)

  • Markus M. Lerch

    (University of Greifswald)

  • Joshua R. Lewis

    (University of Western Australia
    University of Sydney)

  • Lars Lind

    (Uppsala University)

  • Cecilia Lindgren

    (Oxford University)

  • Yongmei Liu

    (Wake Forest School of Medicine)

  • Tian Liu

    (Max Planck Institute for Molecular Genetics
    Max Planck Institute for Human Development)

  • Youfang Liu

    (University of North Carolina at Chapel Hill)

  • Östen Ljunggren

    (Uppsala University)

  • Mattias Lorentzon

    (University of Gothenburg)

  • Robert N. Luben

    (University of Cambridge)

  • William Maixner

    (University of North Carolina at Chapel Hill)

  • Fiona E. McGuigan

    (Lund University)

  • Carolina Medina-Gomez

    (Erasmus MC
    Erasmus MC)

  • Thomas Meitinger

    (Technische Universität München
    Institute of Human Genetics, Helmholtz Zentrum München - German Research Center for Environmental Health)

  • Håkan Melhus

    (Uppsala University)

  • Dan Mellström

    (University of Gothenburg)

  • Simon Melov

    (Buck Institute for Research on Aging
    University of Southern California)

  • Karl Michaëlsson

    (Uppsala University)

  • Braxton D. Mitchell

    (University of Maryland School of Medicine
    Baltimore Veterans Administration Medical Center)

  • Andrew P. Morris

    (Oxford University
    University of Liverpool)

  • Leif Mosekilde

    (Aarhus University Hospital)

  • Anne Newman

    (University of Pittsburgh)

  • Carrie M. Nielson

    (Oregon Health & Science University)

  • Jeffrey R. O’Connell

    (University of Maryland School of Medicine)

  • Ben A. Oostra

    (Erasmus MC
    Centre for Medical Systems Biology and Netherlands Consortium on Healthy Aging)

  • Eric S. Orwoll

    (Oregon Health & Science University)

  • Aarno Palotie

    (University of Helsinki
    University of Helsinki and University Central Hospital)

  • Stephen C. J. Parker

    (University of Michigan)

  • Munro Peacock

    (Indiana University School of Medicine)

  • Markus Perola

    (National Institute for Health and Welfare
    University of Helsinki
    University of Helsinki
    University of Tartu)

  • Annette Peters

    (Helmholtz Zentrum München – German Research Center for Environmental Health
    Helmholtz Zentrum München - German Research Center for Environmental Health)

  • Ozren Polasek

    (University of Split)

  • Richard L. Prince

    (University of Western Australia
    Sir Charles Gardiner Hospital)

  • Katri Räikkönen

    (University of Helsinki)

  • Stuart H. Ralston

    (Western General Hospital)

  • Samuli Ripatti

    (University of Helsinki
    University of Helsinki
    Wellcome Trust Genome Campus)

  • John A. Robbins

    (University of California at Davis)

  • Jerome I. Rotter

    (Harbor UCLA Medical Center)

  • Igor Rudan

    (University of Edinburgh)

  • Veikko Salomaa

    (National Institute for Health and Welfare)

  • Suzanne Satterfield

    (University of Tennessee Health Science Center)

  • Eric E. Schadt

    (Icahn School of Medicine at Mount Sinai)

  • Sabine Schipf

    (University of Greifswald)

  • Laura Scott

    (University of Michigan)

  • Joban Sehmi

    (Ealing Hospital NHS Trust
    Imperial College London)

  • Jian Shen

    (Oregon Health & Science University)

  • Chan Soo Shin

    (Seoul National University College of Medicine)

  • Gunnar Sigurdsson

    (University of Iceland
    The National University Hospital of Iceland)

  • Shad Smith

    (Duke University Medical Center)

  • Nicole Soranzo

    (Wellcome Trust Genome Campus)

  • Alena Stančáková

    (University of Eastern Finland and Kuopio University Hospital)

  • Elisabeth Steinhagen-Thiessen

    (Charité – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health)

  • Elizabeth A. Streeten

    (University of Maryland School of Medicine
    Geriatric Research and Education Clinical Center (GRECC) - Veterans Administration Medical Center)

  • Unnur Styrkarsdottir

    (deCODE Genetics)

  • Karin M. A. Swart

    (VU University Medical Center)

  • Sian-Tsung Tan

    (Ealing Hospital NHS Trust
    Imperial College London)

  • Mark A. Tarnopolsky

    (McMaster University Medical Center)

  • Patricia Thompson

    (Stony Brook School of Medicine)

  • Cynthia A. Thomson

    (University of Arizona)

  • Unnur Thorsteinsdottir

    (University of Iceland
    deCODE Genetics)

  • Emmi Tikkanen

    (National Institute for Health and Welfare
    University of Helsinki
    Western General Hospital)

  • Gregory J. Tranah

    (California Pacific Medical Center Research Institute)

  • Jaakko Tuomilehto

    (Vasa Central Hospital
    Danube-University Krems
    King Abdulaziz University
    Dasman Diabetes Institute)

  • Natasja M. Schoor

    (VU University Medical Center)

  • Arjun Verma

    (Ealing Hospital NHS Trust)

  • Peter Vollenweider

    (Centre Hospitalier Universitaire Vaudois (CHUV))

  • Henry Völzke

    (University of Greifswald)

  • Jean Wactawski-Wende

    (University at Buffalo, State University of New York)

  • Mark Walker

    (Newcastle University)

  • Michael N. Weedon

    (University of Exeter Medical School)

  • Ryan Welch

    (University of Michigan)

  • H.-Erich Wichmann

    (Helmholtz Zentrum München – German Research Center for Environmental Health
    Ludwig-Maximilians-Universität
    Technical University)

  • Elisabeth Widen

    (University of Helsinki)

  • Frances M. K. Williams

    (St Thomas’ Campus)

  • James F. Wilson

    (University of Edinburgh
    University of Edinburgh)

  • Nicole C. Wright

    (University of Alabama at Birmingham)

  • Weijia Xie

    (University of Exeter Medical School)

  • Lei Yu

    (Rush University Medical Center)

  • Yanhua Zhou

    (Boston University School of Public Health)

  • John C. Chambers

    (Imperial College
    Ealing Hospital NHS Trust
    NIHR Cardiovascular Biomedical Research Unit, Royal Brompton and Harefield NHS Foundation Trust and Imperial College
    Imperial College Healthcare NHS Trust)

  • Angela Döring

    (Helmholtz Zentrum München – German Research Center for Environmental Health
    Institute of Epidemiology I, Helmholtz Zentrum München - German Research Center for Environmental Health)

  • Cornelia M. Duijn

    (Erasmus MC
    Centre for Medical Systems Biology and Netherlands Consortium on Healthy Aging)

  • Michael J. Econs

    (Indiana University School of Medicine)

  • Vilmundur Gudnason

    (Icelandic Heart Association
    University of Iceland)

  • Jaspal S. Kooner

    (Ealing Hospital NHS Trust
    Imperial College London
    Imperial College Healthcare NHS Trust)

  • Bruce M. Psaty

    (University of Washington
    Kaiser Permanente Washington Health Research Institute, Washington)

  • Timothy D. Spector

    (St Thomas’ Campus)

  • Kari Stefansson

    (University of Iceland
    deCODE Genetics)

  • Fernando Rivadeneira

    (Erasmus MC
    Netherlands Genomics Initiative (NGI)-sponsored Netherlands Consortium for Healthy Aging (NCHA)
    Erasmus MC)

  • André G. Uitterlinden

    (Erasmus MC
    Netherlands Genomics Initiative (NGI)-sponsored Netherlands Consortium for Healthy Aging (NCHA)
    Erasmus MC)

  • Nicholas J. Wareham

    (Cambridge Biomedical Campus)

  • Vicky Ossowski

    (National Institute of Diabetes and Digestive and Kidney Diseases, NIH)

  • Dawn Waterworth

    (Medical Genetics, GlaxoSmithKline)

  • Ruth J. F. Loos

    (Cambridge Biomedical Campus
    Icahn School of Medicine at Mount Sinai
    Icahn School of Medicine at Mount Sinai
    Icahn School of Medicine at Mount Sinai)

  • David Karasik

    (Hebrew SeniorLife, Institute for Aging Research
    Harvard Medical School
    Bar-Ilan University)

  • Tamara B. Harris

    (National Institute for Aging)

  • Claes Ohlsson

    (University of Gothenburg)

  • Douglas P. Kiel

    (Hebrew SeniorLife, Institute for Aging Research
    Harvard Medical School
    Beth Israel Deaconess Medical Center)

Abstract

Lean body mass, consisting mostly of skeletal muscle, is important for healthy aging. We performed a genome-wide association study for whole body (20 cohorts of European ancestry with n = 38,292) and appendicular (arms and legs) lean body mass (n = 28,330) measured using dual energy X-ray absorptiometry or bioelectrical impedance analysis, adjusted for sex, age, height, and fat mass. Twenty-one single-nucleotide polymorphisms were significantly associated with lean body mass either genome wide (p

Suggested Citation

  • M. Carola Zillikens & Serkalem Demissie & Yi-Hsiang Hsu & Laura M. Yerges-Armstrong & Wen-Chi Chou & Lisette Stolk & Gregory Livshits & Linda Broer & Toby Johnson & Daniel L. Koller & Zoltán Kutalik &, 2017. "Large meta-analysis of genome-wide association studies identifies five loci for lean body mass," Nature Communications, Nature, vol. 8(1), pages 1-13, December.
    • Handle: RePEc:nat:natcom:v:8:y:2017:i:1:d:10.1038_s41467-017-00031-7
    DOI: 10.1038/s41467-017-00031-7
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    1. Louise Grahnemo & Maria Nethander & Eivind Coward & Maiken Elvestad Gabrielsen & Satya Sree & Jean-Marc Billod & Klara Sjögren & Lars Engstrand & Koen F. Dekkers & Tove Fall & Arnulf Langhammer & Kris, 2023. "Identification of three bacterial species associated with increased appendicular lean mass: the HUNT study," Nature Communications, Nature, vol. 14(1), pages 1-9, December.

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