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Full activation pattern mapping by simultaneous deep brain stimulation and fMRI with graphene fiber electrodes

Author

Listed:
  • Siyuan Zhao

    (Peking University
    Peking University)

  • Gen Li

    (Peking University)

  • Chuanjun Tong

    (Chinese Academy of Sciences
    Southern Medical University)

  • Wenjing Chen

    (Chinese Academy of Sciences)

  • Puxin Wang

    (Peking University
    Peking University)

  • Jiankun Dai

    (Chinese Academy of Sciences)

  • Xuefeng Fu

    (Peking University)

  • Zheng Xu

    (Peking University)

  • Xiaojun Liu

    (Peking University)

  • Linlin Lu

    (Peking University)

  • Zhifeng Liang

    (Chinese Academy of Sciences)

  • Xiaojie Duan

    (Peking University
    Peking University)

Abstract

Simultaneous deep brain stimulation (DBS) and functional magnetic resonance imaging (fMRI) constitutes a powerful tool for elucidating brain functional connectivity, and exploring neuromodulatory mechanisms of DBS therapies. Previous DBS-fMRI studies could not provide full activation pattern maps due to poor MRI compatibility of the DBS electrodes, which caused obstruction of large brain areas on MRI scans. Here, we fabricate graphene fiber (GF) electrodes with high charge-injection-capacity and little-to-no MRI artifact at 9.4T. DBS-fMRI with GF electrodes at the subthalamic nucleus (STN) in Parkinsonian rats reveal robust blood-oxygenation-level-dependent responses along the basal ganglia-thalamocortical network in a frequency-dependent manner, with responses from some regions not previously detectable. This full map indicates that STN-DBS modulates both motor and non-motor pathways, possibly through orthodromic and antidromic signal propagation. With the capability for full, unbiased activation pattern mapping, DBS-fMRI using GF electrodes can provide important insights into DBS therapeutic mechanisms in various neurological disorders.

Suggested Citation

  • Siyuan Zhao & Gen Li & Chuanjun Tong & Wenjing Chen & Puxin Wang & Jiankun Dai & Xuefeng Fu & Zheng Xu & Xiaojun Liu & Linlin Lu & Zhifeng Liang & Xiaojie Duan, 2020. "Full activation pattern mapping by simultaneous deep brain stimulation and fMRI with graphene fiber electrodes," Nature Communications, Nature, vol. 11(1), pages 1-12, December.
    • Handle: RePEc:nat:natcom:v:11:y:2020:i:1:d:10.1038_s41467-020-15570-9
    DOI: 10.1038/s41467-020-15570-9
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    Cited by:

    1. Yalin Yu & Yue Qiu & Gen Li & Kaiwei Zhang & Binshi Bo & Mengchao Pei & Jingjing Ye & Garth J. Thompson & Jing Cang & Fang Fang & Yanqiu Feng & Xiaojie Duan & Chuanjun Tong & Zhifeng Liang, 2023. "Sleep fMRI with simultaneous electrophysiology at 9.4 T in male mice," Nature Communications, Nature, vol. 14(1), pages 1-18, December.

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