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Characterization of SARS-CoV-2 Omicron BA.2.75 clinical isolates

Author

Listed:
  • Ryuta Uraki

    (University of Tokyo
    National Center for Global Health and Medicine Research Institute)

  • Shun Iida

    (National Institute of Infectious Diseases)

  • Peter J. Halfmann

    (University of Wisconsin-Madison)

  • Seiya Yamayoshi

    (University of Tokyo
    National Center for Global Health and Medicine Research Institute)

  • Yuichiro Hirata

    (National Institute of Infectious Diseases)

  • Kiyoko Iwatsuki-Horimoto

    (University of Tokyo)

  • Maki Kiso

    (University of Tokyo)

  • Mutsumi Ito

    (University of Tokyo)

  • Yuri Furusawa

    (University of Tokyo
    National Center for Global Health and Medicine Research Institute)

  • Hiroshi Ueki

    (University of Tokyo
    National Center for Global Health and Medicine Research Institute)

  • Yuko Sakai-Tagawa

    (University of Tokyo)

  • Makoto Kuroda

    (University of Wisconsin-Madison)

  • Tadashi Maemura

    (University of Wisconsin-Madison)

  • Taksoo Kim

    (University of Wisconsin-Madison)

  • Sohtaro Mine

    (National Institute of Infectious Diseases)

  • Noriko Iwamoto

    (National Center for Global Health and Medicine Hospital)

  • Rong Li

    (Utah State University)

  • Yanan Liu

    (Utah State University)

  • Deanna Larson

    (Utah State University)

  • Shuetsu Fukushi

    (National Institute of Infectious Diseases)

  • Shinji Watanabe

    (National Institute of Infectious Diseases)

  • Ken Maeda

    (National Institute of Infectious Diseases)

  • Zhongde Wang

    (Utah State University)

  • Norio Ohmagari

    (National Center for Global Health and Medicine Hospital)

  • James Theiler

    (Los Alamos National Laboratory)

  • Will Fischer

    (Los Alamos National Laboratory
    New Mexico Consortium)

  • Bette Korber

    (Los Alamos National Laboratory
    New Mexico Consortium)

  • Masaki Imai

    (University of Tokyo
    National Center for Global Health and Medicine Research Institute)

  • Tadaki Suzuki

    (National Institute of Infectious Diseases)

  • Yoshihiro Kawaoka

    (University of Tokyo
    National Center for Global Health and Medicine Research Institute
    University of Wisconsin-Madison
    The University of Tokyo, Pandemic Preparedness, Infection and Advanced Research Center)

Abstract

The prevalence of the Omicron subvariant BA.2.75 rapidly increased in India and Nepal during the summer of 2022, and spread globally. However, the virological features of BA.2.75 are largely unknown. Here, we evaluated the replicative ability and pathogenicity of BA.2.75 clinical isolates in Syrian hamsters. Although we found no substantial differences in weight change among hamsters infected with BA.2, BA.5, or BA.2.75, the replicative ability of BA.2.75 in the lungs is higher than that of BA.2 and BA.5. Of note, BA.2.75 causes focal viral pneumonia in hamsters, characterized by patchy inflammation interspersed in alveolar regions, which is not observed in BA.5-infected hamsters. Moreover, in competition assays, BA.2.75 replicates better than BA.5 in the lungs of hamsters. These results suggest that BA.2.75 can cause more severe respiratory disease than BA.5 and BA.2 in a hamster model and should be closely monitored.

Suggested Citation

  • Ryuta Uraki & Shun Iida & Peter J. Halfmann & Seiya Yamayoshi & Yuichiro Hirata & Kiyoko Iwatsuki-Horimoto & Maki Kiso & Mutsumi Ito & Yuri Furusawa & Hiroshi Ueki & Yuko Sakai-Tagawa & Makoto Kuroda , 2023. "Characterization of SARS-CoV-2 Omicron BA.2.75 clinical isolates," Nature Communications, Nature, vol. 14(1), pages 1-11, December.
    • Handle: RePEc:nat:natcom:v:14:y:2023:i:1:d:10.1038_s41467-023-37059-x
    DOI: 10.1038/s41467-023-37059-x
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    References listed on IDEAS

    as
    1. Max Kozlov, 2022. "Omicron’s feeble attack on the lungs could make it less dangerous," Nature, Nature, vol. 601(7892), pages 177-177, January.
    2. Ryuta Uraki & Peter J. Halfmann & Shun Iida & Seiya Yamayoshi & Yuri Furusawa & Maki Kiso & Mutsumi Ito & Kiyoko Iwatsuki-Horimoto & Sohtaro Mine & Makoto Kuroda & Tadashi Maemura & Yuko Sakai-Tagawa , 2022. "Characterization of SARS-CoV-2 Omicron BA.4 and BA.5 isolates in rodents," Nature, Nature, vol. 612(7940), pages 540-545, December.
    3. Bo Meng & Adam Abdullahi & Isabella A. T. M. Ferreira & Niluka Goonawardane & Akatsuki Saito & Izumi Kimura & Daichi Yamasoba & Pehuén Pereyra Gerber & Saman Fatihi & Surabhi Rathore & Samantha K. Zep, 2022. "Altered TMPRSS2 usage by SARS-CoV-2 Omicron impacts infectivity and fusogenicity," Nature, Nature, vol. 603(7902), pages 706-714, March.
    4. Seiya Ozono & Yanzhao Zhang & Hirotaka Ode & Kaori Sano & Toong Seng Tan & Kazuo Imai & Kazuyasu Miyoshi & Satoshi Kishigami & Takamasa Ueno & Yasumasa Iwatani & Tadaki Suzuki & Kenzo Tokunaga, 2021. "SARS-CoV-2 D614G spike mutation increases entry efficiency with enhanced ACE2-binding affinity," Nature Communications, Nature, vol. 12(1), pages 1-9, December.
    5. Peter J. Halfmann & Shun Iida & Kiyoko Iwatsuki-Horimoto & Tadashi Maemura & Maki Kiso & Suzanne M. Scheaffer & Tamarand L. Darling & Astha Joshi & Samantha Loeber & Gagandeep Singh & Stephanie L. Fos, 2022. "SARS-CoV-2 Omicron virus causes attenuated disease in mice and hamsters," Nature, Nature, vol. 603(7902), pages 687-692, March.
    6. Ryuta Uraki & Maki Kiso & Shun Iida & Masaki Imai & Emi Takashita & Makoto Kuroda & Peter J. Halfmann & Samantha Loeber & Tadashi Maemura & Seiya Yamayoshi & Seiichiro Fujisaki & Zhongde Wang & Mutsum, 2022. "Characterization and antiviral susceptibility of SARS-CoV-2 Omicron BA.2," Nature, Nature, vol. 607(7917), pages 119-127, July.
    7. Sin Fun Sia & Li-Meng Yan & Alex W. H. Chin & Kevin Fung & Ka-Tim Choy & Alvina Y. L. Wong & Prathanporn Kaewpreedee & Ranawaka A. P. M. Perera & Leo L. M. Poon & John M. Nicholls & Malik Peiris & Hui, 2020. "Pathogenesis and transmission of SARS-CoV-2 in golden hamsters," Nature, Nature, vol. 583(7818), pages 834-838, July.
    Full references (including those not matched with items on IDEAS)

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