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The crucial role of adhesion in the transmigration of active droplets through interstitial orifices

Author

Listed:
  • A. Tiribocchi

    (Istituto per le Applicazioni del Calcolo CNR)

  • M. Durve

    (Istituto Italiano di Tecnologia)

  • M. Lauricella

    (Istituto per le Applicazioni del Calcolo CNR)

  • A. Montessori

    (Roma Tre University)

  • D. Marenduzzo

    (University of Edinburgh)

  • S. Succi

    (Istituto per le Applicazioni del Calcolo CNR
    Istituto Italiano di Tecnologia
    Harvard University)

Abstract

Active fluid droplets are a class of soft materials exhibiting autonomous motion sustained by an energy supply. Such systems have been shown to capture motility regimes typical of biological cells and are ideal candidates as building-block for the fabrication of soft biomimetic materials of interest in pharmacology, tissue engineering and lab on chip devices. While their behavior is well established in unconstrained environments, much less is known about their dynamics under strong confinement. Here, we numerically study the physics of a droplet of active polar fluid migrating within a microchannel hosting a constriction with adhesive properties, and report evidence of a striking variety of dynamic regimes and morphological features, whose properties crucially depend upon droplet speed and elasticity, degree of confinement within the constriction and adhesiveness to the pore. Our results suggest that non-uniform adhesion forces are instrumental in enabling the crossing through narrow orifices, in contrast to larger gaps where a careful balance between speed and elasticity is sufficient to guarantee the transition. These observations may be useful for improving the design of artificial micro-swimmers, of interest in material science and pharmaceutics, and potentially for cell sorting in microfluidic devices.

Suggested Citation

  • A. Tiribocchi & M. Durve & M. Lauricella & A. Montessori & D. Marenduzzo & S. Succi, 2023. "The crucial role of adhesion in the transmigration of active droplets through interstitial orifices," Nature Communications, Nature, vol. 14(1), pages 1-12, December.
  • Handle: RePEc:nat:natcom:v:14:y:2023:i:1:d:10.1038_s41467-023-36656-0
    DOI: 10.1038/s41467-023-36656-0
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    References listed on IDEAS

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    1. Hanumantha Rao Vutukuri & Masoud Hoore & Clara Abaurrea-Velasco & Lennard Buren & Alessandro Dutto & Thorsten Auth & Dmitry A. Fedosov & Gerhard Gompper & Jan Vermant, 2020. "Active particles induce large shape deformations in giant lipid vesicles," Nature, Nature, vol. 586(7827), pages 52-56, October.
    2. Rui Zhang & Ye Zhou & Mohammad Rahimi & Juan J. de Pablo, 2016. "Dynamic structure of active nematic shells," Nature Communications, Nature, vol. 7(1), pages 1-9, December.
    3. Yutaka Sumino & Ken H. Nagai & Yuji Shitaka & Dan Tanaka & Kenichi Yoshikawa & Hugues Chaté & Kazuhiro Oiwa, 2012. "Large-scale vortex lattice emerging from collectively moving microtubules," Nature, Nature, vol. 483(7390), pages 448-452, March.
    4. Thuan Beng Saw & Amin Doostmohammadi & Vincent Nier & Leyla Kocgozlu & Sumesh Thampi & Yusuke Toyama & Philippe Marcq & Chwee Teck Lim & Julia M. Yeomans & Benoit Ladoux, 2017. "Topological defects in epithelia govern cell death and extrusion," Nature, Nature, vol. 544(7649), pages 212-216, April.
    5. Tim Sanchez & Daniel T. N. Chen & Stephen J. DeCamp & Michael Heymann & Zvonimir Dogic, 2012. "Spontaneous motion in hierarchically assembled active matter," Nature, Nature, vol. 491(7424), pages 431-434, November.
    6. E. Tjhung & A. Tiribocchi & D. Marenduzzo & M. E. Cates, 2015. "A minimal physical model captures the shapes of crawling cells," Nature Communications, Nature, vol. 6(1), pages 1-9, May.
    7. Matthew S. E. Peterson & Aparna Baskaran & Michael F. Hagan, 2021. "Vesicle shape transformations driven by confined active filaments," Nature Communications, Nature, vol. 12(1), pages 1-9, December.
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