IDEAS home Printed from https://ideas.repec.org/a/nat/natcom/v14y2023i1d10.1038_s41467-023-41700-0.html
   My bibliography  Save this article

Mechanically induced pyroptosis enhances cardiosphere oxidative stress resistance and metabolism for myocardial infarction therapy

Author

Listed:
  • Yingwei Wang

    (Jinan University)

  • Qi Li

    (Jinan University)

  • Jupeng Zhao

    (Jinan University)

  • Jiamin Chen

    (Jinan University)

  • Dongxue Wu

    (First Affiliated Hospital of Jinan University)

  • Youling Zheng

    (Jinan University)

  • Jiaxin Wu

    (Jinan University)

  • Jie Liu

    (Jinan University)

  • Jianlong Lu

    (Jinan University)

  • Jianhua Zhang

    (First Affiliated Hospital of Jinan University)

  • Zheng Wu

    (Jinan University)

Abstract

Current approaches in myocardial infarction treatment are limited by low cellular oxidative stress resistance, reducing the long-term survival of therapeutic cells. Here we develop a liquid-crystal substrate with unique surface properties and mechanical responsiveness to produce size-controllable cardiospheres that undergo pyroptosis to improve cellular bioactivities and resistance to oxidative stress. We perform RNA sequencing and study cell metabolism to reveal increased metabolic levels and improved mitochondrial function in the preconditioned cardiospheres. We test therapeutic outcomes in a rat model of myocardial infarction to show that cardiospheres improve long-term cardiac function, promote angiogenesis and reduce cardiac remodeling during the 3-month observation. Overall, this study presents a promising and effective system for preparing a large quantity of functional cardiospheres, showcasing potential for clinical application.

Suggested Citation

  • Yingwei Wang & Qi Li & Jupeng Zhao & Jiamin Chen & Dongxue Wu & Youling Zheng & Jiaxin Wu & Jie Liu & Jianlong Lu & Jianhua Zhang & Zheng Wu, 2023. "Mechanically induced pyroptosis enhances cardiosphere oxidative stress resistance and metabolism for myocardial infarction therapy," Nature Communications, Nature, vol. 14(1), pages 1-16, December.
  • Handle: RePEc:nat:natcom:v:14:y:2023:i:1:d:10.1038_s41467-023-41700-0
    DOI: 10.1038/s41467-023-41700-0
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/s41467-023-41700-0
    File Function: Abstract
    Download Restriction: no

    File URL: https://libkey.io/10.1038/s41467-023-41700-0?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    References listed on IDEAS

    as
    1. Kyogo Kawaguchi & Ryoichiro Kageyama & Masaki Sano, 2017. "Topological defects control collective dynamics in neural progenitor cell cultures," Nature, Nature, vol. 545(7654), pages 327-331, May.
    2. Thuan Beng Saw & Amin Doostmohammadi & Vincent Nier & Leyla Kocgozlu & Sumesh Thampi & Yusuke Toyama & Philippe Marcq & Chwee Teck Lim & Julia M. Yeomans & Benoit Ladoux, 2017. "Topological defects in epithelia govern cell death and extrusion," Nature, Nature, vol. 544(7649), pages 212-216, April.
    3. Soon-Jung Park & Ri Youn Kim & Bong-Woo Park & Sunghun Lee & Seong Woo Choi & Jae-Hyun Park & Jong Jin Choi & Seok-Won Kim & Jinah Jang & Dong-Woo Cho & Hyung-Min Chung & Sung-Hwan Moon & Kiwon Ban & , 2019. "Dual stem cell therapy synergistically improves cardiac function and vascular regeneration following myocardial infarction," Nature Communications, Nature, vol. 10(1), pages 1-12, December.
    Full references (including those not matched with items on IDEAS)

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. Julia Eckert & Benoît Ladoux & René-Marc Mège & Luca Giomi & Thomas Schmidt, 2023. "Hexanematic crossover in epithelial monolayers depends on cell adhesion and cell density," Nature Communications, Nature, vol. 14(1), pages 1-9, December.
    2. Pragya Arora & Souvik Sadhukhan & Saroj Kumar Nandi & Dapeng Bi & A. K. Sood & Rajesh Ganapathy, 2024. "A shape-driven reentrant jamming transition in confluent monolayers of synthetic cell-mimics," Nature Communications, Nature, vol. 15(1), pages 1-10, December.
    3. Claire Leclech & David Gonzalez-Rodriguez & Aurélien Villedieu & Thévy Lok & Anne-Marie Déplanche & Abdul I. Barakat, 2022. "Topography-induced large-scale antiparallel collective migration in vascular endothelium," Nature Communications, Nature, vol. 13(1), pages 1-11, December.
    4. Mehrana R. Nejad & Liam J. Ruske & Molly McCord & Jun Zhang & Guanming Zhang & Jacob Notbohm & Julia M. Yeomans, 2024. "Stress-shape misalignment in confluent cell layers," Nature Communications, Nature, vol. 15(1), pages 1-8, December.
    5. Antonio Lamura & Adriano Tiribocchi, 2021. "Shearing Effects on the Phase Coarsening of Binary Mixtures Using the Active Model B," Mathematics, MDPI, vol. 9(23), pages 1-13, November.
    6. Japinder Nijjer & Changhao Li & Qiuting Zhang & Haoran Lu & Sulin Zhang & Jing Yan, 2021. "Mechanical forces drive a reorientation cascade leading to biofilm self-patterning," Nature Communications, Nature, vol. 12(1), pages 1-9, December.
    7. Eleonora Di Piazza & Elisabetta Pandolfi & Ilaria Cacciotti & Andrea Del Fattore & Alberto Eugenio Tozzi & Aurelio Secinaro & Luca Borro, 2021. "Bioprinting Technology in Skin, Heart, Pancreas and Cartilage Tissues: Progress and Challenges in Clinical Practice," IJERPH, MDPI, vol. 18(20), pages 1-29, October.
    8. Sorosh Amiri & Camelia Muresan & Xingbo Shang & Clotilde Huet-Calderwood & Martin A. Schwartz & David A. Calderwood & Michael Murrell, 2023. "Intracellular tension sensor reveals mechanical anisotropy of the actin cytoskeleton," Nature Communications, Nature, vol. 14(1), pages 1-15, December.
    9. Ye Yang & Yaozhang Yang & Dingyuan Liu & Yuanyuan Wang & Minqiao Lu & Qi Zhang & Jiqing Huang & Yongchuan Li & Teng Ma & Fei Yan & Hairong Zheng, 2023. "In-vivo programmable acoustic manipulation of genetically engineered bacteria," Nature Communications, Nature, vol. 14(1), pages 1-14, December.
    10. Tom Brandstätter & David B. Brückner & Yu Long Han & Ricard Alert & Ming Guo & Chase P. Broedersz, 2023. "Curvature induces active velocity waves in rotating spherical tissues," Nature Communications, Nature, vol. 14(1), pages 1-11, December.
    11. Joanny, Jean-François & Indekeu, Joseph O., 2023. "Statistical physics of active matter, cell division and cell aggregation," Physica A: Statistical Mechanics and its Applications, Elsevier, vol. 631(C).
    12. Ariadna Marín-Llauradó & Sohan Kale & Adam Ouzeri & Tom Golde & Raimon Sunyer & Alejandro Torres-Sánchez & Ernest Latorre & Manuel Gómez-González & Pere Roca-Cusachs & Marino Arroyo & Xavier Trepat, 2023. "Mapping mechanical stress in curved epithelia of designed size and shape," Nature Communications, Nature, vol. 14(1), pages 1-11, December.
    13. A. Tiribocchi & M. Durve & M. Lauricella & A. Montessori & D. Marenduzzo & S. Succi, 2023. "The crucial role of adhesion in the transmigration of active droplets through interstitial orifices," Nature Communications, Nature, vol. 14(1), pages 1-12, December.
    14. Yee Han Tee & Wei Jia Goh & Xianbin Yong & Hui Ting Ong & Jinrong Hu & Ignacius Yan Yun Tay & Shidong Shi & Salma Jalal & Samuel F. H. Barnett & Pakorn Kanchanawong & Wenmao Huang & Jie Yan & Yong Ann, 2023. "Actin polymerisation and crosslinking drive left-right asymmetry in single cell and cell collectives," Nature Communications, Nature, vol. 14(1), pages 1-17, December.
    15. Sungjin Min & Suran Kim & Woo-Sup Sim & Yi Sun Choi & Hyebin Joo & Jae-Hyun Park & Su-Jin Lee & Hyeok Kim & Mi Jeong Lee & Inhea Jeong & Baofang Cui & Sung-Hyun Jo & Jin-Ju Kim & Seok Beom Hong & Yeon, 2024. "Versatile human cardiac tissues engineered with perfusable heart extracellular microenvironment for biomedical applications," Nature Communications, Nature, vol. 15(1), pages 1-22, December.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:natcom:v:14:y:2023:i:1:d:10.1038_s41467-023-41700-0. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.