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Topological defects in epithelia govern cell death and extrusion

Author

Listed:
  • Thuan Beng Saw

    (Mechanobiology Institute
    National University of Singapore Graduate School of Integrative Sciences and Engineering (NGS))

  • Amin Doostmohammadi

    (The Rudolf Peierls Centre for Theoretical Physics, University of Oxford)

  • Vincent Nier

    (Laboratoire Physico-Chimie Curie, Sorbonne Universités, UPMC Université Paris 6, Institut Curie, CNRS, UMR 168)

  • Leyla Kocgozlu

    (Mechanobiology Institute)

  • Sumesh Thampi

    (The Rudolf Peierls Centre for Theoretical Physics, University of Oxford
    Indian Institute of Technology Madras)

  • Yusuke Toyama

    (Mechanobiology Institute
    National University of Singapore
    Temasek Life Sciences Laboratory, National University of Singapore)

  • Philippe Marcq

    (Laboratoire Physico-Chimie Curie, Sorbonne Universités, UPMC Université Paris 6, Institut Curie, CNRS, UMR 168)

  • Chwee Teck Lim

    (Mechanobiology Institute
    National University of Singapore Graduate School of Integrative Sciences and Engineering (NGS))

  • Julia M. Yeomans

    (The Rudolf Peierls Centre for Theoretical Physics, University of Oxford)

  • Benoit Ladoux

    (Mechanobiology Institute
    Institut Jacques Monod (IJM), Université Paris Diderot, CNRS)

Abstract

By modelling epithelial cells as active nematic liquid crystals, stresses induced at the sites of topological defects are found to be the primary drivers of extrusion and cell death.

Suggested Citation

  • Thuan Beng Saw & Amin Doostmohammadi & Vincent Nier & Leyla Kocgozlu & Sumesh Thampi & Yusuke Toyama & Philippe Marcq & Chwee Teck Lim & Julia M. Yeomans & Benoit Ladoux, 2017. "Topological defects in epithelia govern cell death and extrusion," Nature, Nature, vol. 544(7649), pages 212-216, April.
    • Handle: RePEc:nat:nature:v:544:y:2017:i:7649:d:10.1038_nature21718
    DOI: 10.1038/nature21718
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    Citations

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    Cited by:

    1. Joanny, Jean-François & Indekeu, Joseph O., 2023. "Statistical physics of active matter, cell division and cell aggregation," Physica A: Statistical Mechanics and its Applications, Elsevier, vol. 631(C).
    2. Julia Eckert & Benoît Ladoux & René-Marc Mège & Luca Giomi & Thomas Schmidt, 2023. "Hexanematic crossover in epithelial monolayers depends on cell adhesion and cell density," Nature Communications, Nature, vol. 14(1), pages 1-9, December.
    3. Yee Han Tee & Wei Jia Goh & Xianbin Yong & Hui Ting Ong & Jinrong Hu & Ignacius Yan Yun Tay & Shidong Shi & Salma Jalal & Samuel F. H. Barnett & Pakorn Kanchanawong & Wenmao Huang & Jie Yan & Yong Ann, 2023. "Actin polymerisation and crosslinking drive left-right asymmetry in single cell and cell collectives," Nature Communications, Nature, vol. 14(1), pages 1-17, December.
    4. A. Tiribocchi & M. Durve & M. Lauricella & A. Montessori & D. Marenduzzo & S. Succi, 2023. "The crucial role of adhesion in the transmigration of active droplets through interstitial orifices," Nature Communications, Nature, vol. 14(1), pages 1-12, December.
    5. Sorosh Amiri & Camelia Muresan & Xingbo Shang & Clotilde Huet-Calderwood & Martin A. Schwartz & David A. Calderwood & Michael Murrell, 2023. "Intracellular tension sensor reveals mechanical anisotropy of the actin cytoskeleton," Nature Communications, Nature, vol. 14(1), pages 1-15, December.
    6. Mehrana R. Nejad & Liam J. Ruske & Molly McCord & Jun Zhang & Guanming Zhang & Jacob Notbohm & Julia M. Yeomans, 2024. "Stress-shape misalignment in confluent cell layers," Nature Communications, Nature, vol. 15(1), pages 1-8, December.
    7. Ariadna Marín-Llauradó & Sohan Kale & Adam Ouzeri & Tom Golde & Raimon Sunyer & Alejandro Torres-Sánchez & Ernest Latorre & Manuel Gómez-González & Pere Roca-Cusachs & Marino Arroyo & Xavier Trepat, 2023. "Mapping mechanical stress in curved epithelia of designed size and shape," Nature Communications, Nature, vol. 14(1), pages 1-11, December.
    8. Japinder Nijjer & Changhao Li & Qiuting Zhang & Haoran Lu & Sulin Zhang & Jing Yan, 2021. "Mechanical forces drive a reorientation cascade leading to biofilm self-patterning," Nature Communications, Nature, vol. 12(1), pages 1-9, December.
    9. Yingwei Wang & Qi Li & Jupeng Zhao & Jiamin Chen & Dongxue Wu & Youling Zheng & Jiaxin Wu & Jie Liu & Jianlong Lu & Jianhua Zhang & Zheng Wu, 2023. "Mechanically induced pyroptosis enhances cardiosphere oxidative stress resistance and metabolism for myocardial infarction therapy," Nature Communications, Nature, vol. 14(1), pages 1-16, December.
    10. Pragya Arora & Souvik Sadhukhan & Saroj Kumar Nandi & Dapeng Bi & A. K. Sood & Rajesh Ganapathy, 2024. "A shape-driven reentrant jamming transition in confluent monolayers of synthetic cell-mimics," Nature Communications, Nature, vol. 15(1), pages 1-10, December.
    11. Tom Brandstätter & David B. Brückner & Yu Long Han & Ricard Alert & Ming Guo & Chase P. Broedersz, 2023. "Curvature induces active velocity waves in rotating spherical tissues," Nature Communications, Nature, vol. 14(1), pages 1-11, December.
    12. Antonio Lamura & Adriano Tiribocchi, 2021. "Shearing Effects on the Phase Coarsening of Binary Mixtures Using the Active Model B," Mathematics, MDPI, vol. 9(23), pages 1-13, November.

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