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Ultrasensitive rapid cytokine sensors based on asymmetric geometry two-dimensional MoS2 diodes

Author

Listed:
  • Thushani Silva

    (Simon Fraser University)

  • Mirette Fawzy

    (Simon Fraser University)

  • Amirhossein Hasani

    (Simon Fraser University)

  • Hamidreza Ghanbari

    (Simon Fraser University)

  • Amin Abnavi

    (Simon Fraser University)

  • Abdelrahman Askar

    (Simon Fraser University)

  • Yue Ling

    (Simon Fraser University)

  • Mohammad Reza Mohammadzadeh

    (Simon Fraser University)

  • Fahmid Kabir

    (Simon Fraser University)

  • Ribwar Ahmadi

    (Simon Fraser University)

  • Miriam Rosin

    (Simon Fraser University)

  • Karen L. Kavanagh

    (Simon Fraser University)

  • Michael M. Adachi

    (Simon Fraser University)

Abstract

The elevation of cytokine levels in body fluids has been associated with numerous health conditions. The detection of these cytokine biomarkers at low concentrations may help clinicians diagnose diseases at an early stage. Here, we report an asymmetric geometry MoS2 diode-based biosensor for rapid, label-free, highly sensitive, and specific detection of tumor necrosis factor-α (TNF-α), a proinflammatory cytokine. This sensor is functionalized with TNF-α binding aptamers to detect TNF-α at concentrations as low as 10 fM, well below the typical concentrations found in healthy blood. Interactions between aptamers and TNF-α at the sensor surface induce a change in surface energy that alters the current-voltage rectification behavior of the MoS2 diode, which can be read out using a two-electrode configuration. The key advantages of this diode sensor are the simple fabrication process and electrical readout, and therefore, the potential to be applied in a rapid and easy-to-use, point-of-care, diagnostic tool.

Suggested Citation

  • Thushani Silva & Mirette Fawzy & Amirhossein Hasani & Hamidreza Ghanbari & Amin Abnavi & Abdelrahman Askar & Yue Ling & Mohammad Reza Mohammadzadeh & Fahmid Kabir & Ribwar Ahmadi & Miriam Rosin & Kare, 2022. "Ultrasensitive rapid cytokine sensors based on asymmetric geometry two-dimensional MoS2 diodes," Nature Communications, Nature, vol. 13(1), pages 1-10, December.
    • Handle: RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-022-35278-2
    DOI: 10.1038/s41467-022-35278-2
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    References listed on IDEAS

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