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Polymer-supported membranes as models of the cell surface

Author

Listed:
  • Motomu Tanaka

    (Technical University of Munich
    University of Heidelberg)

  • Erich Sackmann

    (Technical University of Munich)

Abstract

Lipid-bilayer membranes supported on solid substrates are widely used as cell-surface models that connect biological and artificial materials. They can be placed either directly on solids or on ultrathin polymer supports that mimic the generic role of the extracellular matrix. The tools of modern genetic engineering and bioorganic chemistry make it possible to couple many types of biomolecule to supported membranes. This results in sophisticated interfaces that can be used to control, organize and study the properties and function of membranes and membrane-associated proteins. Particularly exciting opportunities arise when these systems are coupled with advanced semiconductor technology.

Suggested Citation

  • Motomu Tanaka & Erich Sackmann, 2005. "Polymer-supported membranes as models of the cell surface," Nature, Nature, vol. 437(7059), pages 656-663, September.
    • Handle: RePEc:nat:nature:v:437:y:2005:i:7059:d:10.1038_nature04164
    DOI: 10.1038/nature04164
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    Cited by:

    1. Lizhi Liu & Dingyi Pan & Sheng Chen & Maria-Viola Martikainen & Anna Kårlund & Jing Ke & Herkko Pulkkinen & Hanna Ruhanen & Marjut Roponen & Reijo Käkelä & Wujun Xu & Jie Wang & Vesa-Pekka Lehto, 2022. "Systematic design of cell membrane coating to improve tumor targeting of nanoparticles," Nature Communications, Nature, vol. 13(1), pages 1-15, December.
    2. Thomas Kaindl & Harden Rieger & Lisa-Mareike Kaschel & Ulrike Engel & Anja Schmaus & Jonathan Sleeman & Motomu Tanaka, 2012. "Spatio-Temporal Patterns of Pancreatic Cancer Cells Expressing CD44 Isoforms on Supported Membranes Displaying Hyaluronic Acid Oligomers Arrays," PLOS ONE, Public Library of Science, vol. 7(8), pages 1-10, August.

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