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Photocatalysis-mediated drug-free sustainable cancer therapy using nanocatalyst

Author

Listed:
  • Bin Zhao

    (Shenzhen University)

  • Yingshuai Wang

    (Shenzhen University)

  • Xianxian Yao

    (Shenzhen University)

  • Danyang Chen

    (Shenzhen University
    Shanghai Jiao Tong University)

  • Mingjian Fan

    (Shenzhen University)

  • Zhaokui Jin

    (Shenzhen University)

  • Qianjun He

    (Shenzhen University
    Shanghai Jiao Tong University)

Abstract

Drug therapy unavoidably brings toxic side effects and drug content-limited therapeutic efficacy although many nanocarriers have been developed to improve them to a certain extent. In this work, a concept of drug-free therapeutics is proposed and defined as a therapeutic methodology without the use of traditional toxic drugs, without the consumption of therapeutic agents during treatment but with the inexhaustible therapeutic capability to maximize the benefit of treatment, and a Z-scheme SnS1.68-WO2.41 nanocatalyst is developed to achieve near infrared (NIR)-photocatalytic generation of oxidative holes and hydrogen molecules for realizing combined hole/hydrogen therapy by the drug-free therapeutic strategy. Without the need of any drug and other therapeutic agent assistance, the nanocatalyst oxidizes/consumes intratumoral over-expressed glutathione (GSH) by holes and simultaneously generates hydrogen molecules in a lasting and controllable way under NIR irradiation. Mechanistically, generated hydrogen molecules and GSH consumption inhibit cancer cell energy and destroy intratumoral redox balance, respectively, to synergistically damage DNA and induce tumor cell apoptosis. High efficacy and biosafety of combined hole/hydrogen therapy of tumors are achieved by the nanocatalyst. The proposed catalysis-based drug-free therapeutic strategy breaks a pathway to realize high efficacy and low toxicity of cancer treatment.

Suggested Citation

  • Bin Zhao & Yingshuai Wang & Xianxian Yao & Danyang Chen & Mingjian Fan & Zhaokui Jin & Qianjun He, 2021. "Photocatalysis-mediated drug-free sustainable cancer therapy using nanocatalyst," Nature Communications, Nature, vol. 12(1), pages 1-11, December.
  • Handle: RePEc:nat:natcom:v:12:y:2021:i:1:d:10.1038_s41467-021-21618-1
    DOI: 10.1038/s41467-021-21618-1
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    Cited by:

    1. Shengqiang Chen & Yanxia Zhu & Qingqing Xu & Qi Jiang & Danyang Chen & Ting Chen & Xishen Xu & Zhaokui Jin & Qianjun He, 2022. "Photocatalytic glucose depletion and hydrogen generation for diabetic wound healing," Nature Communications, Nature, vol. 13(1), pages 1-11, December.
    2. Yaguang Li & Xianhua Bai & Dachao Yuan & Fengyu Zhang & Bo Li & Xingyuan San & Baolai Liang & Shufang Wang & Jun Luo & Guangsheng Fu, 2022. "General heterostructure strategy of photothermal materials for scalable solar-heating hydrogen production without the consumption of artificial energy," Nature Communications, Nature, vol. 13(1), pages 1-10, December.
    3. Yufu Tang & Yuanyuan Li & Bowen Li & Wentao Song & Guobin Qi & Jianwu Tian & Wei Huang & Quli Fan & Bin Liu, 2024. "Oxygen-independent organic photosensitizer with ultralow-power NIR photoexcitation for tumor-specific photodynamic therapy," Nature Communications, Nature, vol. 15(1), pages 1-13, December.
    4. Zhaokui Jin & Lingdong Jiang & Qianjun He, 2024. "Critical learning from industrial catalysis for nanocatalytic medicine," Nature Communications, Nature, vol. 15(1), pages 1-11, December.
    5. Nailin Yang & Fei Gong & Bo Liu & Yu Hao & Yu Chao & Huali Lei & Xiaoyuan Yang & Yuehan Gong & Xianwen Wang & Zhuang Liu & Liang Cheng, 2022. "Magnesium galvanic cells produce hydrogen and modulate the tumor microenvironment to inhibit cancer growth," Nature Communications, Nature, vol. 13(1), pages 1-12, December.

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