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Photosynthesis-inspired H2 generation using a chlorophyll-loaded liposomal nanoplatform to detect and scavenge excess ROS

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Listed:
  • Wei-Lin Wan

    (National Tsing Hua University)

  • Bo Tian

    (National Tsing Hua University)

  • Yu-Jung Lin

    (National Tsing Hua University)

  • Chiranjeevi Korupalli

    (National Tsing Hua University)

  • Ming-Yen Lu

    (National Tsing Hua University)

  • Qinghua Cui

    (National Tsing Hua University)

  • Dehui Wan

    (National Tsing Hua University)

  • Yen Chang

    (Tzu Chi University)

  • Hsing-Wen Sung

    (National Tsing Hua University)

Abstract

A disturbance of reactive oxygen species (ROS) homeostasis may cause the pathogenesis of many diseases. Inspired by natural photosynthesis, this work proposes a photo-driven H2-evolving liposomal nanoplatform (Lip NP) that comprises an upconversion nanoparticle (UCNP) that is conjugated with gold nanoparticles (AuNPs) via a ROS-responsive linker, which is encapsulated inside the liposomal system in which the lipid bilayer embeds chlorophyll a (Chla). The UCNP functions as a transducer, converting NIR light into upconversion luminescence for simultaneous imaging and therapy in situ. Functioning as light-harvesting antennas, AuNPs are used to detect the local concentration of ROS for FRET biosensing, while the Chla activates the photosynthesis of H2 gas to scavenge local excess ROS. The results thus obtained indicate the potential of using the Lip NPs in the analysis of biological tissues, restoring their ROS homeostasis, possibly preventing the initiation and progression of diseases.

Suggested Citation

  • Wei-Lin Wan & Bo Tian & Yu-Jung Lin & Chiranjeevi Korupalli & Ming-Yen Lu & Qinghua Cui & Dehui Wan & Yen Chang & Hsing-Wen Sung, 2020. "Photosynthesis-inspired H2 generation using a chlorophyll-loaded liposomal nanoplatform to detect and scavenge excess ROS," Nature Communications, Nature, vol. 11(1), pages 1-9, December.
    • Handle: RePEc:nat:natcom:v:11:y:2020:i:1:d:10.1038_s41467-020-14413-x
    DOI: 10.1038/s41467-020-14413-x
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    Cited by:

    1. Shengqiang Chen & Yanxia Zhu & Qingqing Xu & Qi Jiang & Danyang Chen & Ting Chen & Xishen Xu & Zhaokui Jin & Qianjun He, 2022. "Photocatalytic glucose depletion and hydrogen generation for diabetic wound healing," Nature Communications, Nature, vol. 13(1), pages 1-11, December.
    2. Jinwoo Shin & Dong Won Kang & Jong Hyeon Lim & Jong Min An & Youngseo Kim & Ji Hyeon Kim & Myung Sun Ji & Sungnam Park & Dokyoung Kim & Jin Yong Lee & Jong Seung Kim & Chang Seop Hong, 2023. "Wavelength engineerable porous organic polymer photosensitizers with protonation triggered ROS generation," Nature Communications, Nature, vol. 14(1), pages 1-13, December.
    3. Nailin Yang & Fei Gong & Bo Liu & Yu Hao & Yu Chao & Huali Lei & Xiaoyuan Yang & Yuehan Gong & Xianwen Wang & Zhuang Liu & Liang Cheng, 2022. "Magnesium galvanic cells produce hydrogen and modulate the tumor microenvironment to inhibit cancer growth," Nature Communications, Nature, vol. 13(1), pages 1-12, December.

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