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Wavelength engineerable porous organic polymer photosensitizers with protonation triggered ROS generation

Author

Listed:
  • Jinwoo Shin

    (Korea University
    Stanford University)

  • Dong Won Kang

    (Korea University)

  • Jong Hyeon Lim

    (Sungkyunkwan University)

  • Jong Min An

    (Kyung Hee University)

  • Youngseo Kim

    (Korea University)

  • Ji Hyeon Kim

    (Korea University)

  • Myung Sun Ji

    (Korea University)

  • Sungnam Park

    (Korea University)

  • Dokyoung Kim

    (Kyung Hee University
    Kyung Hee University
    Kyung Hee University
    UC San Diego Materials Research Science and Engineering Center)

  • Jin Yong Lee

    (Sungkyunkwan University)

  • Jong Seung Kim

    (Korea University)

  • Chang Seop Hong

    (Korea University)

Abstract

Engineering excitation wavelength of photosensitizers (PSs) for enhanced reactive oxygen species (ROS) generation has inspired new windows for opportunities, enabling investigation of previously impracticable biomedical and photocatalytic applications. However, controlling the wavelength corresponding to operating conditions remains challenging while maintaining high ROS generation. To address this challenge, we implement a wavelength-engineerable imidazolium-based porous organic photocatalytic ROS generation system (KUP system) via a cost-effective one-pot reaction. Remarkably, the optimal wavelength for maximum performance can be tuned by modifying the linker, generating ROS despite the absence of metal ions and covalently attached heavy atoms. We demonstrate that protonated polymerization exclusively enables photosensitization and closely interacts with oxygen related to the efficiency of photosensitizing. Furthermore, superior tumor eradication and biocompatibility of the KUP system were confirmed through bioassays. Overall, the results document an unprecedented polymerization method capable of engineering wavelength, providing a potential basis for designing nanoscale photosensitizers in various ROS-utilizing applications.

Suggested Citation

  • Jinwoo Shin & Dong Won Kang & Jong Hyeon Lim & Jong Min An & Youngseo Kim & Ji Hyeon Kim & Myung Sun Ji & Sungnam Park & Dokyoung Kim & Jin Yong Lee & Jong Seung Kim & Chang Seop Hong, 2023. "Wavelength engineerable porous organic polymer photosensitizers with protonation triggered ROS generation," Nature Communications, Nature, vol. 14(1), pages 1-13, December.
  • Handle: RePEc:nat:natcom:v:14:y:2023:i:1:d:10.1038_s41467-023-37156-x
    DOI: 10.1038/s41467-023-37156-x
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    References listed on IDEAS

    as
    1. Liangbo Xie & Pengfei Wang & Yi Li & Dongpeng Zhang & Denghui Shang & Wenwen Zheng & Yuguo Xia & Sihui Zhan & Wenping Hu, 2022. "Pauling-type adsorption of O2 induced electrocatalytic singlet oxygen production on N–CuO for organic pollutants degradation," Nature Communications, Nature, vol. 13(1), pages 1-11, December.
    2. Wei-Lin Wan & Bo Tian & Yu-Jung Lin & Chiranjeevi Korupalli & Ming-Yen Lu & Qinghua Cui & Dehui Wan & Yen Chang & Hsing-Wen Sung, 2020. "Photosynthesis-inspired H2 generation using a chlorophyll-loaded liposomal nanoplatform to detect and scavenge excess ROS," Nature Communications, Nature, vol. 11(1), pages 1-9, December.
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    Cited by:

    1. Yufu Tang & Yuanyuan Li & Bowen Li & Wentao Song & Guobin Qi & Jianwu Tian & Wei Huang & Quli Fan & Bin Liu, 2024. "Oxygen-independent organic photosensitizer with ultralow-power NIR photoexcitation for tumor-specific photodynamic therapy," Nature Communications, Nature, vol. 15(1), pages 1-13, December.

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