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Photooxidation triggered ultralong afterglow in carbon nanodots

Author

Listed:
  • Guang-Song Zheng

    (Zhengzhou University)

  • Cheng-Long Shen

    (Zhengzhou University)

  • Chun-Yao Niu

    (Zhengzhou University)

  • Qing Lou

    (Zhengzhou University)

  • Tian-Ci Jiang

    (The First Affiliated Hospital of Zhengzhou University
    Zhengzhou University)

  • Peng-Fei Li

    (The First Affiliated Hospital of Zhengzhou University
    Zhengzhou University)

  • Xiao-Jing Shi

    (Zhengzhou University)

  • Run-Wei Song

    (Zhengzhou University)

  • Yuan Deng

    (Zhengzhou University)

  • Chao-Fan Lv

    (Zhengzhou University)

  • Kai-Kai Liu

    (Zhengzhou University)

  • Jin-Hao Zang

    (Zhengzhou University)

  • Zhe Cheng

    (The First Affiliated Hospital of Zhengzhou University
    Zhengzhou University)

  • Lin Dong

    (Zhengzhou University)

  • Chong-Xin Shan

    (Zhengzhou University)

Abstract

It remains a challenge to obtain biocompatible afterglow materials with long emission wavelengths, durable lifetimes, and good water solubility. Herein we develop a photooxidation strategy to construct near-infrared afterglow carbon nanodots with an extra-long lifetime of up to 5.9 h, comparable to that of the well-known rare-earth or organic long-persistent luminescent materials. Intriguingly, size-dependent afterglow lifetime evolution from 3.4 to 5.9 h has been observed from the carbon nanodots systems in aqueous solution. With structural/ultrafast dynamics analysis and density functional theory simulations, we reveal that the persistent luminescence in carbon nanodots is activated by a photooxidation-induced dioxetane intermediate, which can slowly release and convert energy into luminous emission via the steric hindrance effect of nanoparticles. With the persistent near-infrared luminescence, tissue penetration depth of 20 mm can be achieved. Thanks to the high signal-to-background ratio, biological safety and cancer-specific targeting ability of carbon nanodots, ultralong-afterglow guided surgery has been successfully performed on mice model to remove tumor tissues accurately, demonstrating potential clinical applications. These results may facilitate the development of long-lasting luminescent materials for precision tumor resection.

Suggested Citation

  • Guang-Song Zheng & Cheng-Long Shen & Chun-Yao Niu & Qing Lou & Tian-Ci Jiang & Peng-Fei Li & Xiao-Jing Shi & Run-Wei Song & Yuan Deng & Chao-Fan Lv & Kai-Kai Liu & Jin-Hao Zang & Zhe Cheng & Lin Dong , 2024. "Photooxidation triggered ultralong afterglow in carbon nanodots," Nature Communications, Nature, vol. 15(1), pages 1-13, December.
  • Handle: RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-46668-z
    DOI: 10.1038/s41467-024-46668-z
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    References listed on IDEAS

    as
    1. Yongchao Liu & Lili Teng & Yifan Lyu & Guosheng Song & Xiao-Bing Zhang & Weihong Tan, 2022. "Ratiometric afterglow luminescent nanoplatform enables reliable quantification and molecular imaging," Nature Communications, Nature, vol. 13(1), pages 1-13, December.
    2. Wenhui Gao & Jiuyang He & Lei Chen & Xiangqin Meng & Yana Ma & Liangliang Cheng & Kangsheng Tu & Xingfa Gao & Cui Liu & Mingzhen Zhang & Kelong Fan & Dai-Wen Pang & Xiyun Yan, 2023. "Deciphering the catalytic mechanism of superoxide dismutase activity of carbon dot nanozyme," Nature Communications, Nature, vol. 14(1), pages 1-15, December.
    3. Bijiang Geng & Jinyan Hu & Yuan Li & Shini Feng & Dengyu Pan & Lingyan Feng & Longxiang Shen, 2022. "Near-infrared phosphorescent carbon dots for sonodynamic precision tumor therapy," Nature Communications, Nature, vol. 13(1), pages 1-14, December.
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