IDEAS home Printed from https://ideas.repec.org/a/nat/natcom/v14y2023i1d10.1038_s41467-023-40554-w.html
   My bibliography  Save this article

Elevated binding and functional antibody responses to SARS-CoV-2 in infants versus mothers

Author

Listed:
  • Caitlin I. Stoddard

    (Fred Hutchinson Cancer Center)

  • Kevin Sung

    (Fred Hutchinson Cancer Center)

  • Zak A. Yaffe

    (Fred Hutchinson Cancer Center
    University of Washington)

  • Haidyn Weight

    (Fred Hutchinson Cancer Center)

  • Guillaume Beaudoin-Bussières

    (Université de Montréal
    Université de Montréal)

  • Jared Galloway

    (Fred Hutchinson Cancer Center)

  • Soren Gantt

    (Université de Montréal
    Université de Montréal)

  • Judith Adhiambo

    (University of Nairobi)

  • Emily R. Begnel

    (University of Washington)

  • Ednah Ojee

    (University of Nairobi)

  • Jennifer Slyker

    (University of Washington)

  • Dalton Wamalwa

    (University of Nairobi)

  • John Kinuthia

    (University of Washington
    Kenyatta National Hospital)

  • Andrés Finzi

    (Université de Montréal
    Université de Montréal)

  • Frederick A. Matsen

    (Fred Hutchinson Cancer Center
    Howard Hughes Medical Institute)

  • Dara A. Lehman

    (Fred Hutchinson Cancer Center
    University of Washington)

  • Julie Overbaugh

    (Fred Hutchinson Cancer Center
    Fred Hutchinson Cancer Center)

Abstract

Infant antibody responses to viral infection can differ from those in adults. However, data on the specificity and function of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) antibodies in infants, and direct comparisons between infants and adults are limited. Here, we characterize antibody binding and functionality against Wuhan-Hu-1 (B lineage) strain SARS-CoV-2 in convalescent plasma from 36 postpartum women and 14 of their infants infected with SARS-CoV-2 from a vaccine-naïve prospective cohort in Nairobi, Kenya. We find significantly higher antibody titers against SARS-CoV-2 Spike, receptor binding domain and N-terminal domain, and Spike-expressing cell-surface staining levels in infants versus mothers. Plasma antibodies from mothers and infants bind to similar regions of the Spike S2 subunit, including the fusion peptide (FP) and stem helix-heptad repeat 2. However, infants display higher antibody levels and more consistent antibody escape pathways in the FP region compared to mothers. Finally, infants have significantly higher levels of antibody-dependent cellular cytotoxicity (ADCC), though, surprisingly, Spike pseudovirus neutralization titers between infants and mothers are similar. These results suggest infants develop distinct SARS-CoV-2 binding and functional antibody activities and reveal age-related differences in humoral immunity to SARS-CoV-2 infection that could be relevant to protection and COVID-19 disease outcomes.

Suggested Citation

  • Caitlin I. Stoddard & Kevin Sung & Zak A. Yaffe & Haidyn Weight & Guillaume Beaudoin-Bussières & Jared Galloway & Soren Gantt & Judith Adhiambo & Emily R. Begnel & Ednah Ojee & Jennifer Slyker & Dalto, 2023. "Elevated binding and functional antibody responses to SARS-CoV-2 in infants versus mothers," Nature Communications, Nature, vol. 14(1), pages 1-12, December.
    • Handle: RePEc:nat:natcom:v:14:y:2023:i:1:d:10.1038_s41467-023-40554-w
    DOI: 10.1038/s41467-023-40554-w
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/s41467-023-40554-w
    File Function: Abstract
    Download Restriction: no
    File URL: https://libkey.io/10.1038/s41467-023-40554-w?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    References listed on IDEAS

    as
    1. Chek Meng Poh & Guillaume Carissimo & Bei Wang & Siti Naqiah Amrun & Cheryl Yi-Pin Lee & Rhonda Sin-Ling Chee & Siew-Wai Fong & Nicholas Kim-Wah Yeo & Wen-Hsin Lee & Anthony Torres-Ruesta & Yee-Sin Le, 2020. "Two linear epitopes on the SARS-CoV-2 spike protein that elicit neutralising antibodies in COVID-19 patients," Nature Communications, Nature, vol. 11(1), pages 1-7, December.
    2. Bin Ju & Qi Zhang & Jiwan Ge & Ruoke Wang & Jing Sun & Xiangyang Ge & Jiazhen Yu & Sisi Shan & Bing Zhou & Shuo Song & Xian Tang & Jinfang Yu & Jun Lan & Jing Yuan & Haiyan Wang & Juanjuan Zhao & Shuy, 2020. "Human neutralizing antibodies elicited by SARS-CoV-2 infection," Nature, Nature, vol. 584(7819), pages 115-119, August.
    3. Christian Gaebler & Zijun Wang & Julio C. C. Lorenzi & Frauke Muecksch & Shlomo Finkin & Minami Tokuyama & Alice Cho & Mila Jankovic & Dennis Schaefer-Babajew & Thiago Y. Oliveira & Melissa Cipolla & , 2021. "Evolution of antibody immunity to SARS-CoV-2," Nature, Nature, vol. 591(7851), pages 639-644, March.
    4. Asmaa Hachim & Haogao Gu & Otared Kavian & Masashi Mori & Mike Y. W. Kwan & Wai Hung Chan & Yat Sun Yau & Susan S. Chiu & Owen T. Y. Tsang & David S. C. Hui & Chris K. P. Mok & Fionn N. L. Ma & Eric H, 2022. "SARS-CoV-2 accessory proteins reveal distinct serological signatures in children," Nature Communications, Nature, vol. 13(1), pages 1-14, December.
    Full references (including those not matched with items on IDEAS)

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. Bin Ju & Qing Fan & Miao Wang & Xuejiao Liao & Huimin Guo & Haiyan Wang & Xiangyang Ge & Lei Liu & Zheng Zhang, 2022. "Antigenic sin of wild-type SARS-CoV-2 vaccine shapes poor cross-neutralization of BA.4/5/2.75 subvariants in BA.2 breakthrough infections," Nature Communications, Nature, vol. 13(1), pages 1-6, December.
    2. Haisheng Yu & Banghui Liu & Yudi Zhang & Xijie Gao & Qian Wang & Haitao Xiang & Xiaofang Peng & Caixia Xie & Yaping Wang & Peiyu Hu & Jingrong Shi & Quan Shi & Pingqian Zheng & Chengqian Feng & Guofan, 2023. "Somatically hypermutated antibodies isolated from SARS-CoV-2 Delta infected patients cross-neutralize heterologous variants," Nature Communications, Nature, vol. 14(1), pages 1-14, December.
    3. Suad Hannawi & Linda Saf Eldin & Alaa Abuquta & Ahmad Alamadi & Sally A. Mahmoud & Aala Hassan & Shuping Xu & Jian Li & Dongfang Liu & Adam Abdul Hakeem Baidoo & Dima Ibrahim & Mojtaba Alhaj & Yuanxin, 2023. "Safety and immunogenicity of a tetravalent and bivalent SARS-CoV-2 protein booster vaccine in men," Nature Communications, Nature, vol. 14(1), pages 1-9, December.
    4. Ramon Roozendaal & Laura Solforosi & Daniel J. Stieh & Jan Serroyen & Roel Straetemans & Anna Dari & Muriel Boulton & Frank Wegmann & Sietske K. Rosendahl Huber & Joan E. M. van der Lubbe & Jenny Hend, 2021. "SARS-CoV-2 binding and neutralizing antibody levels after Ad26.COV2.S vaccination predict durable protection in rhesus macaques," Nature Communications, Nature, vol. 12(1), pages 1-10, December.
    5. Leire Campos-Mata & Benjamin Trinité & Andrea Modrego & Sonia Tejedor Vaquero & Edwards Pradenas & Anna Pons-Grífols & Natalia Rodrigo Melero & Diego Carlero & Silvia Marfil & César Santiago & Dàlia R, 2024. "A monoclonal antibody targeting a large surface of the receptor binding motif shows pan-neutralizing SARS-CoV-2 activity," Nature Communications, Nature, vol. 15(1), pages 1-13, December.
    6. Meriem Bekliz & Kenneth Adea & Pauline Vetter & Christiane S. Eberhardt & Krisztina Hosszu-Fellous & Diem-Lan Vu & Olha Puhach & Manel Essaidi-Laziosi & Sophie Waldvogel-Abramowski & Caroline Stephan , 2022. "Neutralization capacity of antibodies elicited through homologous or heterologous infection or vaccination against SARS-CoV-2 VOCs," Nature Communications, Nature, vol. 13(1), pages 1-10, December.
    7. Lisa-Marie Funk & Gereon Poschmann & Fabian Rabe von Pappenheim & Ashwin Chari & Kim M. Stegmann & Antje Dickmanns & Marie Wensien & Nora Eulig & Elham Paknia & Gabi Heyne & Elke Penka & Arwen R. Pear, 2024. "Multiple redox switches of the SARS-CoV-2 main protease in vitro provide opportunities for drug design," Nature Communications, Nature, vol. 15(1), pages 1-18, December.
    8. Grace Kenny & Sophie O’Reilly & Neil Wrigley Kelly & Riya Negi & Colette Gaillard & Dana Alalwan & Gurvin Saini & Tamara Alrawahneh & Nathan Francois & Matthew Angeliadis & Alejandro Abner Garcia Leon, 2023. "Distinct receptor binding domain IgG thresholds predict protective host immunity across SARS-CoV-2 variants and time," Nature Communications, Nature, vol. 14(1), pages 1-11, December.
    9. Xiang Liu & Wern Hann Ng & Eva Zusinaite & Joseph Freitas & Adam Taylor & Venugopal Yerragunta & Shukra Madhaha Aavula & Sambaiah Gorriparthi & Santhakumar Ponsekaran & Rama Lakshmi Bonda & Priyanka M, 2024. "A single-dose intranasal live-attenuated codon deoptimized vaccine provides broad protection against SARS-CoV-2 and its variants," Nature Communications, Nature, vol. 15(1), pages 1-19, December.
    10. Jaime S. Rosa Duque & Xiwei Wang & Daniel Leung & Samuel M. S. Cheng & Carolyn A. Cohen & Xiaofeng Mu & Asmaa Hachim & Yanmei Zhang & Sau Man Chan & Sara Chaothai & Kelvin K. H. Kwan & Karl C. K. Chan, 2022. "Immunogenicity and reactogenicity of SARS-CoV-2 vaccines BNT162b2 and CoronaVac in healthy adolescents," Nature Communications, Nature, vol. 13(1), pages 1-15, December.
    11. Daniel M. Altmann & Catherine J. Reynolds & George Joy & Ashley D. Otter & Joseph M. Gibbons & Corinna Pade & Leo Swadling & Mala K. Maini & Tim Brooks & Amanda Semper & Áine McKnight & Mahdad Noursad, 2023. "Persistent symptoms after COVID-19 are not associated with differential SARS-CoV-2 antibody or T cell immunity," Nature Communications, Nature, vol. 14(1), pages 1-9, December.
    12. Yanqun Wang & An Yan & Deyong Song & Maoqin Duan & Chuangchuang Dong & Jiantao Chen & Zihe Jiang & Yuanzhu Gao & Muding Rao & Jianxia Feng & Zhaoyong Zhang & Ruxi Qi & Xiaomin Ma & Hong Liu & Beibei Y, 2024. "Identification of a highly conserved neutralizing epitope within the RBD region of diverse SARS-CoV-2 variants," Nature Communications, Nature, vol. 15(1), pages 1-15, December.
    13. Brian Walitt & Komudi Singh & Samuel R. LaMunion & Mark Hallett & Steve Jacobson & Kong Chen & Yoshimi Enose-Akahata & Richard Apps & Jennifer J. Barb & Patrick Bedard & Robert J. Brychta & Ashura Wil, 2024. "Deep phenotyping of post-infectious myalgic encephalomyelitis/chronic fatigue syndrome," Nature Communications, Nature, vol. 15(1), pages 1-29, December.
    14. Tomohiro Takano & Takashi Sato & Ryutaro Kotaki & Saya Moriyama & Shuetsu Fukushi & Masahiro Shinoda & Kiyomi Kabasawa & Nagashige Shimada & Mio Kousaka & Yu Adachi & Taishi Onodera & Kazutaka Terahar, 2023. "Heterologous SARS-CoV-2 spike protein booster elicits durable and broad antibody responses against the receptor-binding domain," Nature Communications, Nature, vol. 14(1), pages 1-13, December.
    15. Laurent Renia & Yun Shan Goh & Angeline Rouers & Nina Bert & Wan Ni Chia & Jean-Marc Chavatte & Siew‐Wai Fong & Zi Wei Chang & Nicole Ziyi Zhuo & Matthew Zirui Tay & Yi-Hao Chan & Chee Wah Tan & Nicho, 2022. "Lower vaccine-acquired immunity in the elderly population following two-dose BNT162b2 vaccination is alleviated by a third vaccine dose," Nature Communications, Nature, vol. 13(1), pages 1-16, December.
    16. Yubin Liu & Ziyi Wang & Xinyu Zhuang & Shengnan Zhang & Zhicheng Chen & Yan Zou & Jie Sheng & Tianpeng Li & Wanbo Tai & Jinfang Yu & Yanqun Wang & Zhaoyong Zhang & Yunfeng Chen & Liangqin Tong & Xi Yu, 2023. "Inactivated vaccine-elicited potent antibodies can broadly neutralize SARS-CoV-2 circulating variants," Nature Communications, Nature, vol. 14(1), pages 1-17, December.
    17. Marco Mandolesi & Hrishikesh Das & Liset Vries & Yiqiu Yang & Changil Kim & Manojj Dhinakaran & Xaquin Castro Dopico & Julian Fischbach & Sungyong Kim & Mariia V. Guryleva & Monika Àdori & Mark Cherny, 2024. "Multi-compartmental diversification of neutralizing antibody lineages dissected in SARS-CoV-2 spike-immunized macaques," Nature Communications, Nature, vol. 15(1), pages 1-13, December.
    18. Héctor López-Mendoza & Antonio Montañés & F. Javier Moliner-Lahoz, 2021. "Disparities in the Evolution of the COVID-19 Pandemic between Spanish Provinces," IJERPH, MDPI, vol. 18(10), pages 1-20, May.
    19. Yifan Wang & Caixuan Liu & Chao Zhang & Yanxing Wang & Qin Hong & Shiqi Xu & Zuyang Li & Yong Yang & Zhong Huang & Yao Cong, 2022. "Structural basis for SARS-CoV-2 Delta variant recognition of ACE2 receptor and broadly neutralizing antibodies," Nature Communications, Nature, vol. 13(1), pages 1-12, December.
    20. Mendoza, Daniel E. & Ochoa-Sánchez, Ana & Samaniego, Esteban P., 2022. "Forecasting of a complex phenomenon using stochastic data-based techniques under non-conventional schemes: The SARS-CoV-2 virus spread case," Chaos, Solitons & Fractals, Elsevier, vol. 158(C).

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:natcom:v:14:y:2023:i:1:d:10.1038_s41467-023-40554-w. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.