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A key role for autophagy and the autophagy gene Atg16l1 in mouse and human intestinal Paneth cells

Author

Listed:
  • Ken Cadwell

    (Department of Pathology and Immunology,)

  • John Y. Liu

    (Department of Pathology and Immunology,)

  • Sarah L. Brown

    (Department of Pathology and Immunology,)

  • Hiroyuki Miyoshi

    (Department of Pathology and Immunology,)

  • Joy Loh

    (Department of Pathology and Immunology,)

  • Jochen K. Lennerz

    (Department of Pathology and Immunology,)

  • Chieko Kishi

    (Tokyo Medical and Dental University Graduate School and Faculty of Medicine)

  • Wumesh Kc

    (Department of Pathology and Immunology,)

  • Javier A. Carrero

    (Department of Pathology and Immunology,)

  • Steven Hunt

    (Department of Surgery,)

  • Christian D. Stone

    (Department of Medicine,)

  • Elizabeth M. Brunt

    (Department of Pathology and Immunology,)

  • Ramnik J. Xavier

    (Center for Computational and Integrative Biology and Gastrointestinal Unit, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA)

  • Barry P. Sleckman

    (Department of Pathology and Immunology,)

  • Ellen Li

    (Department of Medicine,)

  • Noboru Mizushima

    (Tokyo Medical and Dental University Graduate School and Faculty of Medicine)

  • Thaddeus S. Stappenbeck

    (Department of Pathology and Immunology,)

  • Herbert W. Virgin IV

    (Department of Pathology and Immunology,
    Washington University School of Medicine, St Louis, Missouri 63110, USA)

Abstract

Inflammatory bowel disease Crohn's disease, a chronic inflammation of the gut, has been linked to over thirty gene loci. Two papers in this issue focus a recent addition to that list, ATG16L1 (Atg16-like 1). Atg16 protein itself was first identified in yeast as an essential gene for the process of autophagy, a system that clears away unwanted cellular components and is involved in the pathogenesis of microbial infection, neurodegeneration and tumorigenesis. Cadwell et al. report a unique role for Atg16L1 in Paneth cells, a type of epithelial cell that secretes granules containing antimicrobial peptides into the intestines. Saitoh et al. show that ATG16L1 plays a role in the inflammatory response in isolated macrophages and in the mouse intestine, as an essential component of the autophagic machinery. This work implicates Atg16L1 in the control of inflammatory immune response and the maintenance of intestinal barrier, both of which are important for the prevention of inflammatory bowel disease.

Suggested Citation

  • Ken Cadwell & John Y. Liu & Sarah L. Brown & Hiroyuki Miyoshi & Joy Loh & Jochen K. Lennerz & Chieko Kishi & Wumesh Kc & Javier A. Carrero & Steven Hunt & Christian D. Stone & Elizabeth M. Brunt & Ram, 2008. "A key role for autophagy and the autophagy gene Atg16l1 in mouse and human intestinal Paneth cells," Nature, Nature, vol. 456(7219), pages 259-263, November.
    • Handle: RePEc:nat:nature:v:456:y:2008:i:7219:d:10.1038_nature07416
    DOI: 10.1038/nature07416
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    Cited by:

    1. Lucie Bernard-Raichon & Mericien Venzon & Jon Klein & Jordan E. Axelrad & Chenzhen Zhang & Alexis P. Sullivan & Grant A. Hussey & Arnau Casanovas-Massana & Maria G. Noval & Ana M. Valero-Jimenez & Jua, 2022. "Gut microbiome dysbiosis in antibiotic-treated COVID-19 patients is associated with microbial translocation and bacteremia," Nature Communications, Nature, vol. 13(1), pages 1-13, December.
    2. Lucia Taraborrelli & Yasin Şenbabaoğlu & Lifen Wang & Junghyun Lim & Kerrigan Blake & Noelyn Kljavin & Sarah Gierke & Alexis Scherl & James Ziai & Erin McNamara & Mark Owyong & Shilpa Rao & Aslihan Ka, 2023. "Tumor-intrinsic expression of the autophagy gene Atg16l1 suppresses anti-tumor immunity in colorectal cancer," Nature Communications, Nature, vol. 14(1), pages 1-17, December.
    3. Catherine J. Greene & Jenny A. Nguyen & Samuel M. Cheung & Corey R. Arnold & Dale R. Balce & Ya Ting Wang & Adrian Soderholm & Neil McKenna & Devin Aggarwal & Rhiannon I. Campden & Benjamin W. Ewanchu, 2022. "Macrophages disseminate pathogen associated molecular patterns through the direct extracellular release of the soluble content of their phagolysosomes," Nature Communications, Nature, vol. 13(1), pages 1-17, December.

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