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Multifunctional multi-shank neural probe for investigating and modulating long-range neural circuits in vivo

Author

Listed:
  • Hyogeun Shin

    (Korea Institute of Science and Technology (KIST)
    Korea University of Science and Technology (UST))

  • Yoojin Son

    (Korea Institute of Science and Technology (KIST))

  • Uikyu Chae

    (Korea Institute of Science and Technology (KIST)
    Korea University)

  • Jeongyeon Kim

    (Korea Brain Research Institute)

  • Nakwon Choi

    (Korea Institute of Science and Technology (KIST)
    Korea University of Science and Technology (UST))

  • Hyunjoo J. Lee

    (Korea Advanced Institute of Science and Technology (KAIST))

  • Jiwan Woo

    (Korea Institute of Science and Technology (KIST))

  • Yakdol Cho

    (Korea Institute of Science and Technology (KIST))

  • Soo Hyun Yang

    (Korea University)

  • C. Justin Lee

    (Korea Institute of Science and Technology (KIST))

  • Il-Joo Cho

    (Korea Institute of Science and Technology (KIST)
    Korea University of Science and Technology (UST))

Abstract

Investigation and modulation of neural circuits in vivo at the cellular level are very important for studying functional connectivity in a brain. Recently, neural probes with stimulation capabilities have been introduced, and they provided an opportunity for studying neural activities at a specific region in the brain using various stimuli. However, previous methods have a limitation in dissecting long-range neural circuits due to inherent limitations on their designs. Moreover, the large size of the previously reported probes induces more significant tissue damage. Herein, we present a multifunctional multi-shank MEMS neural probe that is monolithically integrated with an optical waveguide for optical stimulation, microfluidic channels for drug delivery, and microelectrode arrays for recording neural signals from different regions at the cellular level. In this work, we successfully demonstrated the functionality of our probe by confirming and modulating the functional connectivity between the hippocampal CA3 and CA1 regions in vivo.

Suggested Citation

  • Hyogeun Shin & Yoojin Son & Uikyu Chae & Jeongyeon Kim & Nakwon Choi & Hyunjoo J. Lee & Jiwan Woo & Yakdol Cho & Soo Hyun Yang & C. Justin Lee & Il-Joo Cho, 2019. "Multifunctional multi-shank neural probe for investigating and modulating long-range neural circuits in vivo," Nature Communications, Nature, vol. 10(1), pages 1-11, December.
    • Handle: RePEc:nat:natcom:v:10:y:2019:i:1:d:10.1038_s41467-019-11628-5
    DOI: 10.1038/s41467-019-11628-5
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    Cited by:

    1. Yousang Yoon & Hyogeun Shin & Donghak Byun & Jiwan Woo & Yakdol Cho & Nakwon Choi & Il-Joo Cho, 2022. "Neural probe system for behavioral neuropharmacology by bi-directional wireless drug delivery and electrophysiology in socially interacting mice," Nature Communications, Nature, vol. 13(1), pages 1-19, December.
    2. Jongwoon Kim & Hengji Huang & Earl T. Gilbert & Kaiser C. Arndt & Daniel Fine English & Xiaoting Jia, 2024. "T-DOpE probes reveal sensitivity of hippocampal oscillations to cannabinoids in behaving mice," Nature Communications, Nature, vol. 15(1), pages 1-15, December.
    3. Jung Min Lee & Young-Woo Pyo & Yeon Jun Kim & Jin Hee Hong & Yonghyeon Jo & Wonshik Choi & Dingchang Lin & Hong-Gyu Park, 2023. "The ultra-thin, minimally invasive surface electrode array NeuroWeb for probing neural activity," Nature Communications, Nature, vol. 14(1), pages 1-14, December.
    4. Young-Geun Park & Yong Won Kwon & Chin Su Koh & Enji Kim & Dong Ha Lee & Sumin Kim & Jongmin Mun & Yeon-Mi Hong & Sanghoon Lee & Ju-Young Kim & Jae-Hyun Lee & Hyun Ho Jung & Jinwoo Cheon & Jin Woo Cha, 2024. "In-vivo integration of soft neural probes through high-resolution printing of liquid electronics on the cranium," Nature Communications, Nature, vol. 15(1), pages 1-15, December.

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