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High-fluence and high-gain multilayer focusing optics to enhance spatial resolution in femtosecond X-ray laser imaging

Author

Listed:
  • Hirokatsu Yumoto

    (Japan Synchrotron Radiation Research Institute
    RIKEN SPring-8 Center)

  • Takahisa Koyama

    (Japan Synchrotron Radiation Research Institute
    RIKEN SPring-8 Center)

  • Akihiro Suzuki

    (Hokkaido University)

  • Yasumasa Joti

    (Japan Synchrotron Radiation Research Institute
    RIKEN SPring-8 Center)

  • Yoshiya Niida

    (Hokkaido University)

  • Kensuke Tono

    (Japan Synchrotron Radiation Research Institute
    RIKEN SPring-8 Center)

  • Yoshitaka Bessho

    (RIKEN SPring-8 Center
    Academia Sinica)

  • Makina Yabashi

    (Japan Synchrotron Radiation Research Institute
    RIKEN SPring-8 Center)

  • Yoshinori Nishino

    (Hokkaido University)

  • Haruhiko Ohashi

    (Japan Synchrotron Radiation Research Institute
    RIKEN SPring-8 Center)

Abstract

With the emergence of X-ray free-electron lasers (XFELs), coherent diffractive imaging (CDI) has acquired a capability for single-particle imaging (SPI) of non-crystalline objects under non-cryogenic conditions. However, the single-shot spatial resolution is limited to ~5 nanometres primarily because of insufficient fluence. Here, we present a CDI technique whereby high resolution is achieved with very-high-fluence X-ray focusing using multilayer mirrors with nanometre precision. The optics can focus 4-keV XFEL down to 60 nm × 110 nm and realize a fluence of >3 × 105 J cm−2 pulse−1 or >4 × 1012 photons μm−2 pulse−1 with a tenfold increase in the total gain compared to conventional optics due to the high demagnification. Further, the imaging of fixed-target metallic nanoparticles in solution attained an unprecedented 2-nm resolution in single-XFEL-pulse exposure. These findings can further expand the capabilities of SPI to explore the relationships between dynamic structures and functions of native biomolecular complexes.

Suggested Citation

  • Hirokatsu Yumoto & Takahisa Koyama & Akihiro Suzuki & Yasumasa Joti & Yoshiya Niida & Kensuke Tono & Yoshitaka Bessho & Makina Yabashi & Yoshinori Nishino & Haruhiko Ohashi, 2022. "High-fluence and high-gain multilayer focusing optics to enhance spatial resolution in femtosecond X-ray laser imaging," Nature Communications, Nature, vol. 13(1), pages 1-8, December.
  • Handle: RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-022-33014-4
    DOI: 10.1038/s41467-022-33014-4
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    References listed on IDEAS

    as
    1. Richard Neutze & Remco Wouts & David van der Spoel & Edgar Weckert & Janos Hajdu, 2000. "Potential for biomolecular imaging with femtosecond X-ray pulses," Nature, Nature, vol. 406(6797), pages 752-757, August.
    2. Jung-Hoon Lee & Kyle J. Gibson & Gang Chen & Yossi Weizmann, 2015. "Bipyramid-templated synthesis of monodisperse anisotropic gold nanocrystals," Nature Communications, Nature, vol. 6(1), pages 1-9, November.
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    4. Yungok Ihm & Do Hyung Cho & Daeho Sung & Daewoong Nam & Chulho Jung & Takahiro Sato & Sangsoo Kim & Jaehyun Park & Sunam Kim & Marcus Gallagher-Jones & Yoonhee Kim & Rui Xu & Shigeki Owada & Ji Hoon S, 2019. "Direct observation of picosecond melting and disintegration of metallic nanoparticles," Nature Communications, Nature, vol. 10(1), pages 1-6, December.
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