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Magnitude of venous or capillary blood-derived SARS-CoV-2-specific T cell response determines COVID-19 immunity

Author

Listed:
  • Martin J. Scurr

    (Cardiff University
    Cardiff University
    ImmunoServ Ltd.)

  • George Lippiatt

    (ImmunoServ Ltd.)

  • Lorenzo Capitani

    (Cardiff University
    Cardiff University)

  • Kirsten Bentley

    (Cardiff University
    Cardiff University)

  • Sarah N. Lauder

    (Cardiff University
    Cardiff University)

  • Kathryn Smart

    (Cardiff University
    Cardiff University)

  • Michelle S. Somerville

    (Cardiff University
    Cardiff University)

  • Tara Rees

    (Cardiff University
    ImmunoServ Ltd.
    Cardiff & Vale University Health Board)

  • Richard J. Stanton

    (Cardiff University
    Cardiff University)

  • Awen Gallimore

    (Cardiff University
    Cardiff University)

  • James P. Hindley

    (ImmunoServ Ltd.)

  • Andrew Godkin

    (Cardiff University
    Cardiff University
    ImmunoServ Ltd.
    Cardiff & Vale University Health Board)

Abstract

T cells specific for SARS-CoV-2 are thought to protect against infection and development of COVID-19, but direct evidence for this is lacking. Here, we associated whole-blood-based measurement of SARS-CoV-2-specific interferon-γ-positive T cell responses with positive COVID-19 diagnostic (PCR and/or lateral flow) test results up to 6 months post-blood sampling. Amongst 148 participants donating venous blood samples, SARS-CoV-2-specific T cell response magnitude is significantly greater in those who remain protected versus those who become infected (P

Suggested Citation

  • Martin J. Scurr & George Lippiatt & Lorenzo Capitani & Kirsten Bentley & Sarah N. Lauder & Kathryn Smart & Michelle S. Somerville & Tara Rees & Richard J. Stanton & Awen Gallimore & James P. Hindley &, 2022. "Magnitude of venous or capillary blood-derived SARS-CoV-2-specific T cell response determines COVID-19 immunity," Nature Communications, Nature, vol. 13(1), pages 1-9, December.
    • Handle: RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-022-32985-8
    DOI: 10.1038/s41467-022-32985-8
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