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Three SARS-CoV-2 spike protein variants delivered intranasally by measles and mumps vaccines are broadly protective

Author

Listed:
  • Yuexiu Zhang

    (The Ohio State University)

  • Michelle Chamblee

    (The Ohio State University)

  • Jiayu Xu

    (The Ohio State University)

  • Panke Qu

    (The Ohio State University)

  • Mohamed M. Shamseldin

    (College of Medicine, The Ohio State University
    The Ohio State University
    Faculty of Pharmacy, Helwan University, Ain Helwan)

  • Sung J. Yoo

    (The Ohio State University)

  • Jack Misny

    (Abigail Wexner Research Institute at Nationwide Children’s Hospital)

  • Ilada Thongpan

    (Abigail Wexner Research Institute at Nationwide Children’s Hospital)

  • Mahesh KC

    (Abigail Wexner Research Institute at Nationwide Children’s Hospital)

  • Jesse M. Hall

    (College of Medicine, The Ohio State University)

  • Yash A. Gupta

    (College of Medicine, The Ohio State University)

  • John P. Evans

    (The Ohio State University)

  • Mijia Lu

    (The Ohio State University)

  • Chengjin Ye

    (Texas Biomedical Research Institute)

  • Cheng Chih Hsu

    (The Ohio State University)

  • Xueya Liang

    (The Ohio State University)

  • Luis Martinez-Sobrido

    (Texas Biomedical Research Institute)

  • Jacob S. Yount

    (College of Medicine, The Ohio State University
    The Ohio State University)

  • Prosper N. Boyaka

    (The Ohio State University
    The Ohio State University)

  • Shan-Lu Liu

    (The Ohio State University
    College of Medicine, The Ohio State University
    The Ohio State University
    The Ohio State University)

  • Purnima Dubey

    (College of Medicine, The Ohio State University
    The Ohio State University)

  • Mark E. Peeples

    (Abigail Wexner Research Institute at Nationwide Children’s Hospital
    The Ohio State University
    The Ohio State University)

  • Jianrong Li

    (The Ohio State University
    The Ohio State University)

Abstract

As the new SARS-CoV-2 Omicron variants and subvariants emerge, there is an urgency to develop intranasal, broadly protective vaccines. Here, we developed highly efficacious, intranasal trivalent SARS-CoV-2 vaccine candidates (TVC) based on three components of the MMR vaccine: measles virus (MeV), mumps virus (MuV) Jeryl Lynn (JL1) strain, and MuV JL2 strain. Specifically, MeV, MuV-JL1, and MuV-JL2 vaccine strains, each expressing prefusion spike (preS-6P) from a different variant of concern (VoC), were combined to generate TVCs. Intranasal immunization of IFNAR1−/− mice and female hamsters with TVCs generated high levels of S-specific serum IgG antibodies, broad neutralizing antibodies, and mucosal IgA antibodies as well as tissue-resident memory T cells in the lungs. The immunized female hamsters were protected from challenge with SARS-CoV-2 original WA1, B.1.617.2, and B.1.1.529 strains. The preexisting MeV and MuV immunity does not significantly interfere with the efficacy of TVC. Thus, the trivalent platform is a promising next-generation SARS-CoV-2 vaccine candidate.

Suggested Citation

  • Yuexiu Zhang & Michelle Chamblee & Jiayu Xu & Panke Qu & Mohamed M. Shamseldin & Sung J. Yoo & Jack Misny & Ilada Thongpan & Mahesh KC & Jesse M. Hall & Yash A. Gupta & John P. Evans & Mijia Lu & Chen, 2024. "Three SARS-CoV-2 spike protein variants delivered intranasally by measles and mumps vaccines are broadly protective," Nature Communications, Nature, vol. 15(1), pages 1-19, December.
    • Handle: RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-49443-2
    DOI: 10.1038/s41467-024-49443-2
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    References listed on IDEAS

    as
    1. Ewen Callaway, 2023. "The next generation of coronavirus vaccines: a graphical guide," Nature, Nature, vol. 614(7946), pages 22-25, February.
    2. Sho Iketani & Lihong Liu & Yicheng Guo & Liyuan Liu & Jasper F.-W. Chan & Yiming Huang & Maple Wang & Yang Luo & Jian Yu & Hin Chu & Kenn K.-H. Chik & Terrence T.-T. Yuen & Michael T. Yin & Magdalena , 2022. "Antibody evasion properties of SARS-CoV-2 Omicron sublineages," Nature, Nature, vol. 604(7906), pages 553-556, April.
    3. Roanne Keeton & Marius B. Tincho & Amkele Ngomti & Richard Baguma & Ntombi Benede & Akiko Suzuki & Khadija Khan & Sandile Cele & Mallory Bernstein & Farina Karim & Sharon V. Madzorera & Thandeka Moyo-, 2022. "T cell responses to SARS-CoV-2 spike cross-recognize Omicron," Nature, Nature, vol. 603(7901), pages 488-492, March.
    4. Florian Krammer, 2020. "SARS-CoV-2 vaccines in development," Nature, Nature, vol. 586(7830), pages 516-527, October.
    5. Anzhong Li & Jingyou Yu & Mijia Lu & Yuanmei Ma & Zayed Attia & Chao Shan & Miaoge Xue & Xueya Liang & Kelsey Craig & Nirajkumar Makadiya & Jennifer J. He & Ryan Jennings & Pei-Yong Shi & Mark E. Peep, 2018. "A Zika virus vaccine expressing premembrane-envelope-NS1 polyprotein," Nature Communications, Nature, vol. 9(1), pages 1-17, December.
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