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SARS-CoV-2 humoral and cellular immunity following different combinations of vaccination and breakthrough infection

Author

Listed:
  • Jernej Pušnik

    (University Hospital Bonn
    German Center for Infection Research (DZIF), partner site Bonn-Cologne)

  • Werner O. Monzon-Posadas

    (University Hospital Bonn
    German Center for Infection Research (DZIF), partner site Bonn-Cologne
    University Hospital Bonn)

  • Jasmin Zorn

    (University Hospital Bonn
    German Center for Infection Research (DZIF), partner site Bonn-Cologne)

  • Kathrin Peters

    (University Hospital Bonn
    German Center for Infection Research (DZIF), partner site Bonn-Cologne)

  • Maximilian Baum

    (University Hospital Bonn
    German Center for Infection Research (DZIF), partner site Bonn-Cologne)

  • Hannah Proksch

    (University Hospital Bonn
    German Center for Infection Research (DZIF), partner site Bonn-Cologne)

  • Celina Beta Schlüter

    (University Hospital Bonn
    German Center for Infection Research (DZIF), partner site Bonn-Cologne)

  • Galit Alter

    (Ragon Institute of MGH, MIT, and Harvard, Massachusetts General Hospital)

  • Tanja Menting

    (University Hospital Bonn)

  • Hendrik Streeck

    (University Hospital Bonn
    German Center for Infection Research (DZIF), partner site Bonn-Cologne)

Abstract

The elicited anti-SARS-CoV-2 immunity is becoming increasingly complex with individuals receiving a different number of vaccine doses paired with or without recovery from breakthrough infections with different variants. Here we analyze the immunity of individuals that initially received two doses of mRNA vaccine and either received a booster vaccination, recovered from a breakthrough infection, or both. Our data suggest that two vaccine doses and delta breakthrough infection or three vaccine doses and optionally omicron or delta infection provide better B cell immunity than the initial two doses of mRNA vaccine with or without alpha breakthrough infection. A particularly potent B cell response against the currently circulating omicron variant (B. 1.1.529) was observed for thrice vaccinated individuals with omicron breakthrough infection; a 46-fold increase in plasma neutralization compared to two vaccine doses (p

Suggested Citation

  • Jernej Pušnik & Werner O. Monzon-Posadas & Jasmin Zorn & Kathrin Peters & Maximilian Baum & Hannah Proksch & Celina Beta Schlüter & Galit Alter & Tanja Menting & Hendrik Streeck, 2023. "SARS-CoV-2 humoral and cellular immunity following different combinations of vaccination and breakthrough infection," Nature Communications, Nature, vol. 14(1), pages 1-13, December.
    • Handle: RePEc:nat:natcom:v:14:y:2023:i:1:d:10.1038_s41467-023-36250-4
    DOI: 10.1038/s41467-023-36250-4
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