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Microchannelled alkylated chitosan sponge to treat noncompressible hemorrhages and facilitate wound healing

Author

Listed:
  • Xinchen Du

    (Nankai University)

  • Le Wu

    (Nankai University)

  • Hongyu Yan

    (Nankai University)

  • Zhuyan Jiang

    (The Second Hospital of Tianjin Medical University)

  • Shilin Li

    (Nankai University)

  • Wen Li

    (Nankai University)

  • Yanli Bai

    (Nankai University)

  • Hongjun Wang

    (Stevens Institute of Technology)

  • Zhaojun Cheng

    (Shenzhen Traditional Chinese Medicine Hospital)

  • Deling Kong

    (Nankai University)

  • Lianyong Wang

    (Nankai University)

  • Meifeng Zhu

    (Nankai University)

Abstract

Developing an anti-infective shape-memory hemostatic sponge able to guide in situ tissue regeneration for noncompressible hemorrhages in civilian and battlefield settings remains a challenge. Here we engineer hemostatic chitosan sponges with highly interconnective microchannels by combining 3D printed microfiber leaching, freeze-drying, and superficial active modification. We demonstrate that the microchannelled alkylated chitosan sponge (MACS) exhibits the capacity for water and blood absorption, as well as rapid shape recovery. We show that compared to clinically used gauze, gelatin sponge, CELOX™, and CELOX™-gauze, the MACS provides higher pro-coagulant and hemostatic capacities in lethally normal and heparinized rat and pig liver perforation wound models. We demonstrate its anti-infective activity against S. aureus and E. coli and its promotion of liver parenchymal cell infiltration, vascularization, and tissue integration in a rat liver defect model. Overall, the MACS demonstrates promising clinical translational potential in treating lethal noncompressible hemorrhage and facilitating wound healing.

Suggested Citation

  • Xinchen Du & Le Wu & Hongyu Yan & Zhuyan Jiang & Shilin Li & Wen Li & Yanli Bai & Hongjun Wang & Zhaojun Cheng & Deling Kong & Lianyong Wang & Meifeng Zhu, 2021. "Microchannelled alkylated chitosan sponge to treat noncompressible hemorrhages and facilitate wound healing," Nature Communications, Nature, vol. 12(1), pages 1-16, December.
    • Handle: RePEc:nat:natcom:v:12:y:2021:i:1:d:10.1038_s41467-021-24972-2
    DOI: 10.1038/s41467-021-24972-2
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    Cited by:

    1. Guangyu Bao & Qiman Gao & Massimo Cau & Nabil Ali-Mohamad & Mitchell Strong & Shuaibing Jiang & Zhen Yang & Amin Valiei & Zhenwei Ma & Marco Amabili & Zu-Hua Gao & Luc Mongeau & Christian Kastrup & Ji, 2022. "Liquid-infused microstructured bioadhesives halt non-compressible hemorrhage," Nature Communications, Nature, vol. 13(1), pages 1-14, December.
    2. Tianshen Jiang & Sirong Chen & Jingwen Xu & Yuxiao Zhang & Hao Fu & Qiangjun Ling & Yan Xu & Xiangyu Chu & Ruinan Wang & Liangcong Hu & Hao Li & Weitong Huang & Liming Bian & Pengchao Zhao & Fuxin Wei, 2024. "Superporous sponge prepared by secondary network compaction with enhanced permeability and mechanical properties for non-compressible hemostasis in pigs," Nature Communications, Nature, vol. 15(1), pages 1-16, December.
    3. S. M. Shatil Shahriar & Alec D. McCarthy & Syed Muntazir Andrabi & Yajuan Su & Navatha Shree Polavoram & Johnson V. John & Mitchell P. Matis & Wuqiang Zhu & Jingwei Xie, 2024. "Mechanically resilient hybrid aerogels containing fibers of dual-scale sizes and knotty networks for tissue regeneration," Nature Communications, Nature, vol. 15(1), pages 1-15, December.
    4. Huaying He & Weikang Zhou & Jing Gao & Fan Wang & Shaobing Wang & Yan Fang & Yang Gao & Wei Chen & Wen Zhang & Yunxiang Weng & Zhengchao Wang & Haiqing Liu, 2022. "Efficient, biosafe and tissue adhesive hemostatic cotton gauze with controlled balance of hydrophilicity and hydrophobicity," Nature Communications, Nature, vol. 13(1), pages 1-14, December.

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