IDEAS home Printed from https://ideas.repec.org/a/nat/natcom/v9y2018i1d10.1038_s41467-018-04998-9.html
   My bibliography  Save this article

Injectable antibacterial conductive nanocomposite cryogels with rapid shape recovery for noncompressible hemorrhage and wound healing

Author

Listed:
  • Xin Zhao

    (Xi’an Jiaotong University)

  • Baolin Guo

    (Xi’an Jiaotong University)

  • Hao Wu

    (Xi’an Jiaotong University)

  • Yongping Liang

    (Xi’an Jiaotong University)

  • Peter X. Ma

    (University of Michigan
    University of Michigan
    University of Michigan)

Abstract

Developing injectable antibacterial and conductive shape memory hemostatic with high blood absorption and fast recovery for irregularly shaped and noncompressible hemorrhage remains a challenge. Here we report injectable antibacterial conductive cryogels based on carbon nanotube (CNT) and glycidyl methacrylate functionalized quaternized chitosan for lethal noncompressible hemorrhage hemostasis and wound healing. These cryogels present robust mechanical strength, rapid blood-triggered shape recovery and absorption speed, and high blood uptake capacity. Moreover, cryogels show better blood-clotting ability, higher blood cell and platelet adhesion and activation than gelatin sponge and gauze. Cryogel with 4 mg/mL CNT (QCSG/CNT4) shows better hemostatic capability than gauze and gelatin hemostatic sponge in mouse-liver injury model and mouse-tail amputation model, and better wound healing performance than Tegaderm™ film. Importantly, QCSG/CNT4 presents excellent hemostatic performance in rabbit liver defect lethal noncompressible hemorrhage model and even better hemostatic ability than Combat Gauze in standardized circular liver bleeding model.

Suggested Citation

  • Xin Zhao & Baolin Guo & Hao Wu & Yongping Liang & Peter X. Ma, 2018. "Injectable antibacterial conductive nanocomposite cryogels with rapid shape recovery for noncompressible hemorrhage and wound healing," Nature Communications, Nature, vol. 9(1), pages 1-17, December.
    • Handle: RePEc:nat:natcom:v:9:y:2018:i:1:d:10.1038_s41467-018-04998-9
    DOI: 10.1038/s41467-018-04998-9
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/s41467-018-04998-9
    File Function: Abstract
    Download Restriction: no
    File URL: https://libkey.io/10.1038/s41467-018-04998-9?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Guangyu Bao & Qiman Gao & Massimo Cau & Nabil Ali-Mohamad & Mitchell Strong & Shuaibing Jiang & Zhen Yang & Amin Valiei & Zhenwei Ma & Marco Amabili & Zu-Hua Gao & Luc Mongeau & Christian Kastrup & Ji, 2022. "Liquid-infused microstructured bioadhesives halt non-compressible hemorrhage," Nature Communications, Nature, vol. 13(1), pages 1-14, December.
    2. Tianshen Jiang & Sirong Chen & Jingwen Xu & Yuxiao Zhang & Hao Fu & Qiangjun Ling & Yan Xu & Xiangyu Chu & Ruinan Wang & Liangcong Hu & Hao Li & Weitong Huang & Liming Bian & Pengchao Zhao & Fuxin Wei, 2024. "Superporous sponge prepared by secondary network compaction with enhanced permeability and mechanical properties for non-compressible hemostasis in pigs," Nature Communications, Nature, vol. 15(1), pages 1-16, December.
    3. Rui Ye & Ziyu Zhu & Tianyi Gu & Dengjie Cao & Kai Jiang & Qiang Dai & Kuoran Xing & Yifan Jiang & Siyi Zhou & Ping Cai & David Tai Leong & Mengfei Yu & Jie Song, 2024. "Neutrophil extracellular traps-inspired DNA hydrogel for wound hemostatic adjuvant," Nature Communications, Nature, vol. 15(1), pages 1-14, December.
    4. Yan Cui & Zongwang Huang & Li Lei & Qinglin Li & Jinlong Jiang & Qinghai Zeng & Aidong Tang & Huaming Yang & Yi Zhang, 2021. "Robust hemostatic bandages based on nanoclay electrospun membranes," Nature Communications, Nature, vol. 12(1), pages 1-11, December.
    5. Bin Chen & Yudong Cao & Qiaoyu Li & Zhuo Yan & Rui Liu & Yunjiao Zhao & Xiang Zhang & Minying Wu & Yixiu Qin & Chang Sun & Wei Yao & Ziyi Cao & Pulickel M. Ajayan & Mason Oliver Lam Chee & Pei Dong & , 2022. "Liquid metal-tailored gluten network for protein-based e-skin," Nature Communications, Nature, vol. 13(1), pages 1-12, December.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:natcom:v:9:y:2018:i:1:d:10.1038_s41467-018-04998-9. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.