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Mapping effective connectivity of human amygdala subdivisions with intracranial stimulation

Author

Listed:
  • Masahiro Sawada

    (University of Iowa
    Tazuke Kofukai Medical Research Institute and Kitano Hospital)

  • Ralph Adolphs

    (California Institute of Technology)

  • Brian J. Dlouhy

    (University of Iowa
    University of Iowa)

  • Rick L. Jenison

    (University of Wisconsin - Madison)

  • Ariane E. Rhone

    (University of Iowa)

  • Christopher K. Kovach

    (University of Iowa)

  • Jeremy, D. W. Greenlee

    (University of Iowa
    University of Iowa)

  • Matthew A. Howard III

    (University of Iowa
    University of Iowa
    University of Iowa)

  • Hiroyuki Oya

    (University of Iowa
    University of Iowa)

Abstract

The primate amygdala is a complex consisting of over a dozen nuclei that have been implicated in a host of cognitive functions, individual differences, and psychiatric illnesses. These functions are implemented through distinct connectivity profiles, which have been documented in animals but remain largely unknown in humans. Here we present results from 25 neurosurgical patients who had concurrent electrical stimulation of the amygdala with intracranial electroencephalography (electrical stimulation tract-tracing; es-TT), or fMRI (electrical stimulation fMRI; es-fMRI), methods providing strong inferences about effective connectivity of amygdala subdivisions with the rest of the brain. We quantified functional connectivity with medial and lateral amygdala, the temporal order of these connections on the timescale of milliseconds, and also detail second-order effective connectivity among the key nodes. These findings provide a uniquely detailed characterization of human amygdala functional connectivity that will inform functional neuroimaging studies in healthy and clinical populations.

Suggested Citation

  • Masahiro Sawada & Ralph Adolphs & Brian J. Dlouhy & Rick L. Jenison & Ariane E. Rhone & Christopher K. Kovach & Jeremy, D. W. Greenlee & Matthew A. Howard III & Hiroyuki Oya, 2022. "Mapping effective connectivity of human amygdala subdivisions with intracranial stimulation," Nature Communications, Nature, vol. 13(1), pages 1-19, December.
    • Handle: RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-022-32644-y
    DOI: 10.1038/s41467-022-32644-y
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    References listed on IDEAS

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