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A circuit from the ventral subiculum to anterior hypothalamic nucleus GABAergic neurons essential for anxiety-like behavioral avoidance

Author

Listed:
  • Jing-Jing Yan

    (Chinese Academy of Sciences)

  • Xiao-Jing Ding

    (Chinese Academy of Sciences)

  • Ting He

    (Huazhong University of Science and Technology
    Huazhong University of Science and Technology)

  • Ai-Xiao Chen

    (Chinese Academy of Sciences)

  • Wen Zhang

    (Chinese Academy of Sciences)

  • Zi-Xian Yu

    (Chinese Academy of Sciences
    University of Chinese Academy of Sciences)

  • Xin-Yu Cheng

    (National Institute of Biological Sciences
    Chinese Academy of Medical Sciences)

  • Chuan-Yao Wei

    (Chinese Academy of Sciences)

  • Qiao-Dan Hu

    (Chinese Academy of Sciences)

  • Xiao-Yao Liu

    (Chinese Academy of Sciences)

  • Yan-Li Zhang

    (Chinese Academy of Sciences)

  • Mengge He

    (Huazhong University of Science and Technology
    Huazhong University of Science and Technology)

  • Zhi-Yong Xie

    (National Institute of Biological Sciences)

  • Xi Zha

    (Chinese Academy of Sciences)

  • Chun Xu

    (Chinese Academy of Sciences
    Shanghai Center for Brain Science and Brain-Inspired Intelligence Technology)

  • Peng Cao

    (National Institute of Biological Sciences
    Tsinghua University)

  • Haohong Li

    (Zhejiang University School of Brain Science and Brain Medicine)

  • Xiao-Hong Xu

    (Chinese Academy of Sciences
    Shanghai Center for Brain Science and Brain-Inspired Intelligence Technology)

Abstract

Behavioral observations suggest a connection between anxiety and predator defense, but the underlying neural mechanisms remain unclear. Here we examine the role of the anterior hypothalamic nucleus (AHN), a node in the predator defense network, in anxiety-like behaviors. By in vivo recordings in male mice, we find that activity of AHN GABAergic (AHNVgat+) neurons shows individually stable increases when animals approach unfamiliar objects in an open field (OF) or when they explore the open-arm of an elevated plus-maze (EPM). Moreover, object-evoked AHN activity overlap with predator cue responses and correlate with the object and open-arm avoidance. Crucially, exploration-triggered optogenetic inhibition of AHNVgat+ neurons reduces object and open-arm avoidance. Furthermore, retrograde viral tracing identifies the ventral subiculum (vSub) of the hippocampal formation as a significant input to AHNVgat+ neurons in driving avoidance behaviors in anxiogenic situations. Thus, convergent activation of AHNVgat+ neurons serves as a shared mechanism between anxiety and predator defense to promote behavioral avoidance.

Suggested Citation

  • Jing-Jing Yan & Xiao-Jing Ding & Ting He & Ai-Xiao Chen & Wen Zhang & Zi-Xian Yu & Xin-Yu Cheng & Chuan-Yao Wei & Qiao-Dan Hu & Xiao-Yao Liu & Yan-Li Zhang & Mengge He & Zhi-Yong Xie & Xi Zha & Chun X, 2022. "A circuit from the ventral subiculum to anterior hypothalamic nucleus GABAergic neurons essential for anxiety-like behavioral avoidance," Nature Communications, Nature, vol. 13(1), pages 1-16, December.
  • Handle: RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-022-35211-7
    DOI: 10.1038/s41467-022-35211-7
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    References listed on IDEAS

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