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Amygdala circuitry mediating reversible and bidirectional control of anxiety

Author

Listed:
  • Kay M. Tye

    (Stanford University)

  • Rohit Prakash

    (Stanford University
    Neurosciences Program, Stanford University)

  • Sung-Yon Kim

    (Stanford University
    Neurosciences Program, Stanford University)

  • Lief E. Fenno

    (Stanford University
    Neurosciences Program, Stanford University)

  • Logan Grosenick

    (Stanford University
    Neurosciences Program, Stanford University)

  • Hosniya Zarabi

    (Stanford University)

  • Kimberly R. Thompson

    (Stanford University)

  • Viviana Gradinaru

    (Stanford University
    Neurosciences Program, Stanford University)

  • Charu Ramakrishnan

    (Stanford University)

  • Karl Deisseroth

    (Stanford University
    Neurosciences Program, Stanford University
    Stanford University
    Howard Hughes Medical Institute, Stanford University)

Abstract

Neuronal circuitry of anxiety The amygdala, a brain region important for learning fearful memories, is thought to have a role in generalized anxiety, but the subregions and connections involved in this response are unknown. Now, using optogenetic stimulation of basolateral amygdala terminals in the central nucleus of the amygdala of rats, a specific circuit for natural bidirectional anxiety control has been identified. Stimulating these neurons has a calming effect, whereas blocking the same projection increases anxiety-related behaviours. These findings are consistent with a role for the central nucleus of the amygdala in anxiety, although there may be other circuits working in parallel or downstream of the amygdala.

Suggested Citation

  • Kay M. Tye & Rohit Prakash & Sung-Yon Kim & Lief E. Fenno & Logan Grosenick & Hosniya Zarabi & Kimberly R. Thompson & Viviana Gradinaru & Charu Ramakrishnan & Karl Deisseroth, 2011. "Amygdala circuitry mediating reversible and bidirectional control of anxiety," Nature, Nature, vol. 471(7338), pages 358-362, March.
    • Handle: RePEc:nat:nature:v:471:y:2011:i:7338:d:10.1038_nature09820
    DOI: 10.1038/nature09820
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    Cited by:

    1. Carole Morel & Sarah E. Montgomery & Long Li & Romain Durand-de Cuttoli & Emily M. Teichman & Barbara Juarez & Nikos Tzavaras & Stacy M. Ku & Meghan E. Flanigan & Min Cai & Jessica J. Walsh & Scott J., 2022. "Midbrain projection to the basolateral amygdala encodes anxiety-like but not depression-like behaviors," Nature Communications, Nature, vol. 13(1), pages 1-13, December.
    2. Kaizhen Li & Konstantinos Koukoutselos & Masanori Sakaguchi & Stéphane Ciocchi, 2024. "Distinct ventral hippocampal inhibitory microcircuits regulating anxiety and fear behaviors," Nature Communications, Nature, vol. 15(1), pages 1-13, December.
    3. C. Nicolas & A. Ju & Y. Wu & H. Eldirdiri & S. Delcasso & Y. Couderc & C. Fornari & A. Mitra & L. Supiot & A. Vérité & M. Masson & S. Rodriguez-Rozada & D. Jacky & J. S. Wiegert & A. Beyeler, 2023. "Linking emotional valence and anxiety in a mouse insula-amygdala circuit," Nature Communications, Nature, vol. 14(1), pages 1-18, December.
    4. Ren-Wen Han & Zi-Yi Zhang & Chen Jiao & Ze-Yu Hu & Bing-Xing Pan, 2024. "Synergism between two BLA-to-BNST pathways for appropriate expression of anxiety-like behaviors in male mice," Nature Communications, Nature, vol. 15(1), pages 1-18, December.
    5. Sorinel A Oprisan & Xandre Clementsmith & Tamas Tompa & Antonieta Lavin, 2019. "Dopamine receptor antagonists effects on low-dimensional attractors of local field potentials in optogenetic mice," PLOS ONE, Public Library of Science, vol. 14(10), pages 1-39, October.
    6. Masahiro Sawada & Ralph Adolphs & Brian J. Dlouhy & Rick L. Jenison & Ariane E. Rhone & Christopher K. Kovach & Jeremy, D. W. Greenlee & Matthew A. Howard III & Hiroyuki Oya, 2022. "Mapping effective connectivity of human amygdala subdivisions with intracranial stimulation," Nature Communications, Nature, vol. 13(1), pages 1-19, December.
    7. Anna J. Bowen & Y. Waterlily Huang & Jane Y. Chen & Jordan L. Pauli & Carlos A. Campos & Richard D. Palmiter, 2023. "Topographic representation of current and future threats in the mouse nociceptive amygdala," Nature Communications, Nature, vol. 14(1), pages 1-16, December.
    8. Iván J Santos-Soto & Nataliya Chorna & Néstor M Carballeira & José G Vélez-Bartolomei & Ana T Méndez-Merced & Anatoliy P Chornyy & Sandra Peña de Ortiz, 2013. "Voluntary Running in Young Adult Mice Reduces Anxiety-Like Behavior and Increases the Accumulation of Bioactive Lipids in the Cerebral Cortex," PLOS ONE, Public Library of Science, vol. 8(12), pages 1-15, December.
    9. Hansol Lim & Yue Zhang & Christian Peters & Tobias Straub & Johanna Luise Mayer & Rüdiger Klein, 2024. "Genetically- and spatially-defined basolateral amygdala neurons control food consumption and social interaction," Nature Communications, Nature, vol. 15(1), pages 1-22, December.

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