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Human ventromedial prefrontal cortex is necessary for prosocial motivation

Author

Listed:
  • Patricia L. Lockwood

    (University of Birmingham
    University of Birmingham
    University of Oxford
    University of Oxford)

  • Jo Cutler

    (University of Birmingham
    University of Birmingham
    University of Oxford
    University of Oxford)

  • Daniel Drew

    (University of Oxford
    University of Oxford
    University of Oxford)

  • Ayat Abdurahman

    (University of Oxford
    University of Oxford
    University of Cambridge)

  • Deva Sanjeeva Jeyaretna

    (University of Oxford
    John Radcliffe Hospital)

  • Matthew A. J. Apps

    (University of Birmingham
    University of Birmingham
    University of Oxford
    University of Oxford)

  • Masud Husain

    (University of Oxford
    University of Oxford
    University of Oxford
    John Radcliffe Hospital)

  • Sanjay G. Manohar

    (University of Oxford
    University of Oxford
    John Radcliffe Hospital)

Abstract

Ventromedial prefrontal cortex (vmPFC) is vital for decision-making. Functional neuroimaging links vmPFC to processing rewards and effort, while parallel work suggests vmPFC involvement in prosocial behaviour. However, the necessity of vmPFC for these functions is unknown. Patients with rare focal vmPFC lesions (n = 25), patients with lesions elsewhere (n = 15) and healthy controls (n = 40) chose between rest and exerting effort to earn rewards for themselves or another person. vmPFC damage decreased prosociality across behavioural and computational measures. vmPFC patients earned less, discounted rewards by effort more, and exerted less force when another person benefited, compared to both control groups. Voxel-based lesion mapping revealed dissociations between vmPFC subregions. While medial damage led to antisocial behaviour, lateral damage increased prosocial behaviour relative to patients with damage elsewhere. vmPFC patients also showed reduced effort sensitivity overall, but reward sensitivity was limited to specific subregions. These results reveal multiple causal contributions of vmPFC to prosocial behaviour, effort and reward.

Suggested Citation

  • Patricia L. Lockwood & Jo Cutler & Daniel Drew & Ayat Abdurahman & Deva Sanjeeva Jeyaretna & Matthew A. J. Apps & Masud Husain & Sanjay G. Manohar, 2024. "Human ventromedial prefrontal cortex is necessary for prosocial motivation," Nature Human Behaviour, Nature, vol. 8(7), pages 1403-1416, July.
    • Handle: RePEc:nat:nathum:v:8:y:2024:i:7:d:10.1038_s41562-024-01899-4
    DOI: 10.1038/s41562-024-01899-4
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    References listed on IDEAS

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    1. Ernst Fehr & Urs Fischbacher, 2003. "The nature of human altruism," Nature, Nature, vol. 425(6960), pages 785-791, October.
    2. Bates, Douglas & Mächler, Martin & Bolker, Ben & Walker, Steve, 2015. "Fitting Linear Mixed-Effects Models Using lme4," Journal of Statistical Software, Foundation for Open Access Statistics, vol. 67(i01).
    3. Yuen-Siang Ang & Patricia Lockwood & Matthew A J Apps & Kinan Muhammed & Masud Husain, 2017. "Distinct Subtypes of Apathy Revealed by the Apathy Motivation Index," PLOS ONE, Public Library of Science, vol. 12(1), pages 1-15, January.
    4. Jo Cutler & Marco K. Wittmann & Ayat Abdurahman & Luca D. Hargitai & Daniel Drew & Masud Husain & Patricia L. Lockwood, 2021. "Ageing is associated with disrupted reinforcement learning whilst learning to help others is preserved," Nature Communications, Nature, vol. 12(1), pages 1-13, December.
    5. Sébastien Ballesta & Weikang Shi & Katherine E. Conen & Camillo Padoa-Schioppa, 2020. "Values encoded in orbitofrontal cortex are causally related to economic choices," Nature, Nature, vol. 588(7838), pages 450-453, December.
    6. Marco K. Wittmann & Elsa Fouragnan & Davide Folloni & Miriam C. Klein-Flügge & Bolton K. H. Chau & Mehdi Khamassi & Matthew F. S. Rushworth, 2020. "Global reward state affects learning and activity in raphe nucleus and anterior insula in monkeys," Nature Communications, Nature, vol. 11(1), pages 1-17, December.
    7. Michael Koenigs & Liane Young & Ralph Adolphs & Daniel Tranel & Fiery Cushman & Marc Hauser & Antonio Damasio, 2007. "Damage to the prefrontal cortex increases utilitarian moral judgements," Nature, Nature, vol. 446(7138), pages 908-911, April.
    8. Patricia L. Lockwood & Mathilde Hamonet & Samuel H. Zhang & Anya Ratnavel & Florentine U. Salmony & Masud Husain & Matthew A. J. Apps, 2017. "Prosocial apathy for helping others when effort is required," Nature Human Behaviour, Nature, vol. 1(7), pages 1-10, July.
    9. Patricia L. Lockwood & Marco K. Wittmann & Matthew A. J. Apps & Miriam C. Klein-Flügge & Molly J. Crockett & Glyn W. Humphreys & Matthew F. S. Rushworth, 2018. "Neural mechanisms for learning self and other ownership," Nature Communications, Nature, vol. 9(1), pages 1-11, December.
    10. Fabian Kosse & Michela M. Tincani, 2020. "Prosociality predicts labor market success around the world," Nature Communications, Nature, vol. 11(1), pages 1-6, December.
    11. Kosse, Fabian & Tincani, Michaela M., 2020. "Prosociality predicts labor market success around the world," Munich Reprints in Economics 75115, University of Munich, Department of Economics.
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