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Microwave assisted antibacterial action of Garcinia nanoparticles on Gram-negative bacteria

Author

Listed:
  • Yuqian Qiao

    (Tianjin University
    Peking University)

  • Yingde Xu

    (Tianjin University)

  • Xiangmei Liu

    (Hebei University of Technology)

  • Yufeng Zheng

    (Peking University)

  • Bo Li

    (Xi’an Jiaotong University)

  • Yong Han

    (Xi’an Jiaotong University)

  • Zhaoyang Li

    (Tianjin University)

  • Kelvin Wai Kwok Yeung

    (The University of Hong Kong)

  • Yanqin Liang

    (Tianjin University)

  • Shengli Zhu

    (Tianjin University)

  • Zhenduo Cui

    (Tianjin University)

  • Shuilin Wu

    (Tianjin University
    Peking University)

Abstract

Owing to the existence of the outer membrane barrier, most antibacterial agents cannot penetrate Gram-negative bacteria and are ineffective. Here, we report a general method for narrow-spectrum antibacterial Garcinia nanoparticles that can only be effective to kill Gram-positive bacteria, to effectively eliminate Gram-negative bacteria by creating transient nanopores in bacterial outer membrane to induce drug entry under microwaves assistance. In vitro, under 15 min of microwaves irradiation, the antibacterial efficiency of Garcinia nanoparticles against Escherichia coli can be enhanced from 6.73% to 99.48%. In vivo, MV-assisted GNs can effectively cure mice with bacterial pneumonia. The combination of molecular dynamics simulation and experimental results reveal that the robust anti-E. coli effectiveness of Garcinia nanoparticles is attributed to the synergy of Garcinia nanoparticles and microwaves. This work presents a strategy for effectively treating both Gram-negative and Gram-positive bacteria co-infected pneumonia using herbal medicine nanoparticles with MV assistance as an exogenous antibacterial auxiliary.

Suggested Citation

  • Yuqian Qiao & Yingde Xu & Xiangmei Liu & Yufeng Zheng & Bo Li & Yong Han & Zhaoyang Li & Kelvin Wai Kwok Yeung & Yanqin Liang & Shengli Zhu & Zhenduo Cui & Shuilin Wu, 2022. "Microwave assisted antibacterial action of Garcinia nanoparticles on Gram-negative bacteria," Nature Communications, Nature, vol. 13(1), pages 1-13, December.
  • Handle: RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-022-30125-w
    DOI: 10.1038/s41467-022-30125-w
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    References listed on IDEAS

    as
    1. Enrique R. Rojas & Gabriel Billings & Pascal D. Odermatt & George K. Auer & Lillian Zhu & Amanda Miguel & Fred Chang & Douglas B. Weibel & Julie A. Theriot & Kerwyn Casey Huang, 2018. "The outer membrane is an essential load-bearing element in Gram-negative bacteria," Nature, Nature, vol. 559(7715), pages 617-621, July.
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