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Treatment of MRSA-infected osteomyelitis using bacterial capturing, magnetically targeted composites with microwave-assisted bacterial killing

Author

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  • Yuqian Qiao

    (The Key Laboratory of Advanced Ceramics and Machining Technology by the Ministry of Education of China, Tianjin University)

  • Xiangmei Liu

    (Ministry-of-Education Key Laboratory for the Green Preparation and Application of Functional Materials, School of Materials Science & Engineering, Hubei University)

  • Bo Li

    (School of Materials Science and Engineering, Xi’an Jiaotong University)

  • Yong Han

    (School of Materials Science and Engineering, Xi’an Jiaotong University)

  • Yufeng Zheng

    (Peking University)

  • Kelvin Wai Kwok Yeung

    (Li Ka Shing Faculty of Medicine, The University of Hong Kong)

  • Changyi Li

    (Tianjin Medical University)

  • Zhenduo Cui

    (The Key Laboratory of Advanced Ceramics and Machining Technology by the Ministry of Education of China, Tianjin University)

  • Yanqin Liang

    (The Key Laboratory of Advanced Ceramics and Machining Technology by the Ministry of Education of China, Tianjin University)

  • Zhaoyang Li

    (The Key Laboratory of Advanced Ceramics and Machining Technology by the Ministry of Education of China, Tianjin University)

  • Shengli Zhu

    (The Key Laboratory of Advanced Ceramics and Machining Technology by the Ministry of Education of China, Tianjin University)

  • Xianbao Wang

    (Ministry-of-Education Key Laboratory for the Green Preparation and Application of Functional Materials, School of Materials Science & Engineering, Hubei University)

  • Shuilin Wu

    (The Key Laboratory of Advanced Ceramics and Machining Technology by the Ministry of Education of China, Tianjin University)

Abstract

Owing to the poor penetration depth of light, phototherapy, including photothermal and photodynamic therapies, remains severely ineffective in treating deep tissue infections such as methicillin-resistant Staphylococcus aureus (MRSA)-infected osteomyelitis. Here, we report a microwave-excited antibacterial nanocapturer system for treating deep tissue infections that consists of microwave-responsive Fe3O4/CNT and the chemotherapy agent gentamicin (Gent). This system, Fe3O4/CNT/Gent, is proven to efficiently target and eradicate MRSA-infected rabbit tibia osteomyelitis. Its robust antibacterial effectiveness is attributed to the precise bacteria-capturing ability and magnetic targeting of the nanocapturer, as well as the subsequent synergistic effects of precise microwaveocaloric therapy from Fe3O4/CNT and chemotherapy from the effective release of antibiotics in infection sites. The advanced target-nanocapturer of microwave-excited microwaveocaloric-chemotherapy with effective targeting developed in this study makes a major step forward in microwave therapy for deep tissue infections.

Suggested Citation

  • Yuqian Qiao & Xiangmei Liu & Bo Li & Yong Han & Yufeng Zheng & Kelvin Wai Kwok Yeung & Changyi Li & Zhenduo Cui & Yanqin Liang & Zhaoyang Li & Shengli Zhu & Xianbao Wang & Shuilin Wu, 2020. "Treatment of MRSA-infected osteomyelitis using bacterial capturing, magnetically targeted composites with microwave-assisted bacterial killing," Nature Communications, Nature, vol. 11(1), pages 1-13, December.
    • Handle: RePEc:nat:natcom:v:11:y:2020:i:1:d:10.1038_s41467-020-18268-0
    DOI: 10.1038/s41467-020-18268-0
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    Cited by:

    1. Yuqian Qiao & Yingde Xu & Xiangmei Liu & Yufeng Zheng & Bo Li & Yong Han & Zhaoyang Li & Kelvin Wai Kwok Yeung & Yanqin Liang & Shengli Zhu & Zhenduo Cui & Shuilin Wu, 2022. "Microwave assisted antibacterial action of Garcinia nanoparticles on Gram-negative bacteria," Nature Communications, Nature, vol. 13(1), pages 1-13, December.
    2. Jinyong Chen & Tanchen Ren & Lan Xie & Haochang Hu & Xu Li & Miribani Maitusong & Xuhao Zhou & Wangxing Hu & Dilin Xu & Yi Qian & Si Cheng & Kaixiang Yu & Jian`an Wang & Xianbao Liu, 2024. "Enhancing aortic valve drug delivery with PAR2-targeting magnetic nano-cargoes for calcification alleviation," Nature Communications, Nature, vol. 15(1), pages 1-20, December.
    3. Chuang Yang & Yao Luo & Hao Shen & Min Ge & Jin Tang & Qiaojie Wang & Han Lin & Jianlin Shi & Xianlong Zhang, 2022. "Inorganic nanosheets facilitate humoral immunity against medical implant infections by modulating immune co-stimulatory pathways," Nature Communications, Nature, vol. 13(1), pages 1-16, December.

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