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Comparison of clonal architecture between primary and immunodeficient mouse-engrafted acute myeloid leukemia cells

Author

Listed:
  • Naomi Kawashima

    (Nagoya University Graduate School of Medicine)

  • Yuichi Ishikawa

    (Nagoya University Graduate School of Medicine)

  • Jeong Hui Kim

    (Nagoya University Graduate School of Medicine)

  • Yoko Ushijima

    (Nagoya University Graduate School of Medicine)

  • Akimi Akashi

    (Nagoya University Graduate School of Medicine)

  • Yohei Yamaguchi

    (Nagoya University Graduate School of Medicine)

  • Hikaru Hattori

    (Nagoya University Graduate School of Medicine)

  • Marie Nakashima

    (Nagoya University Graduate School of Medicine)

  • Seara Ikeno

    (Nagoya University Graduate School of Medicine)

  • Rika Kihara

    (Komaki City Hospital)

  • Takahiro Nishiyama

    (Ichinomiya Municipal Hospital)

  • Takanobu Morishita

    (Japanese Red Cross Nagoya First Hospital)

  • Koichi Watamoto

    (Komaki City Hospital)

  • Yukiyasu Ozawa

    (Japanese Red Cross Nagoya First Hospital)

  • Kunio Kitamura

    (Ichinomiya Municipal Hospital)

  • Hitoshi Kiyoi

    (Nagoya University Graduate School of Medicine)

Abstract

Patient-derived xenografts (PDX) are widely used as human cancer models. Previous studies demonstrated clonal discordance between PDX and primary cells. However, in acute myeloid leukemia (AML)-PDX models, the significance of the clonal dynamics occurring in PDX remains unclear. By evaluating changes in the variant allele frequencies (VAF) of somatic mutations in serial samples of paired primary AML and their PDX bone marrow cells, we identify the skewing engraftment of relapsed or refractory (R/R) AML clones in 57% of PDX models generated from multiclonal AML cells at diagnosis, even if R/R clones are minor at

Suggested Citation

  • Naomi Kawashima & Yuichi Ishikawa & Jeong Hui Kim & Yoko Ushijima & Akimi Akashi & Yohei Yamaguchi & Hikaru Hattori & Marie Nakashima & Seara Ikeno & Rika Kihara & Takahiro Nishiyama & Takanobu Morish, 2022. "Comparison of clonal architecture between primary and immunodeficient mouse-engrafted acute myeloid leukemia cells," Nature Communications, Nature, vol. 13(1), pages 1-11, December.
    • Handle: RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-022-29304-6
    DOI: 10.1038/s41467-022-29304-6
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