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Tumour micro-environment elicits innate resistance to RAF inhibitors through HGF secretion

Author

Listed:
  • Ravid Straussman

    (The Eli and Edythe L. Broad Institute, 7 Cambridge Center)

  • Teppei Morikawa

    (Dana-Farber Cancer Institute, 450 Brookline Avenue, Boston, Massachusetts 02115, USA)

  • Kevin Shee

    (The Eli and Edythe L. Broad Institute, 7 Cambridge Center)

  • Michal Barzily-Rokni

    (The Eli and Edythe L. Broad Institute, 7 Cambridge Center)

  • Zhi Rong Qian

    (Dana-Farber Cancer Institute, 450 Brookline Avenue, Boston, Massachusetts 02115, USA)

  • Jinyan Du

    (The Eli and Edythe L. Broad Institute, 7 Cambridge Center)

  • Ashli Davis

    (The Eli and Edythe L. Broad Institute, 7 Cambridge Center)

  • Margaret M. Mongare

    (The Eli and Edythe L. Broad Institute, 7 Cambridge Center)

  • Joshua Gould

    (The Eli and Edythe L. Broad Institute, 7 Cambridge Center)

  • Dennie T. Frederick

    (Medical Oncology and Dermatology, Massachusetts General Hospital, 55 Fruit Street, Boston, Massachusetts 02114, USA)

  • Zachary A. Cooper

    (Medical Oncology and Dermatology, Massachusetts General Hospital, 55 Fruit Street, Boston, Massachusetts 02114, USA)

  • Paul B. Chapman

    (Memorial Sloan-Kettering Cancer Center)

  • David B. Solit

    (Memorial Sloan-Kettering Cancer Center
    Human Oncology and Pathogenesis Program, Memorial Sloan-Kettering Cancer Center)

  • Antoni Ribas

    (Jonsson Comprehensive Cancer Center, University of California
    Jonsson Comprehensive Cancer Center, University of California)

  • Roger S. Lo

    (Jonsson Comprehensive Cancer Center, University of California
    Jonsson Comprehensive Cancer Center, University of California)

  • Keith T. Flaherty

    (Medical Oncology and Dermatology, Massachusetts General Hospital, 55 Fruit Street, Boston, Massachusetts 02114, USA)

  • Shuji Ogino

    (Dana-Farber Cancer Institute, 450 Brookline Avenue, Boston, Massachusetts 02115, USA
    Brigham and Women’s Hospital and Harvard Medical School)

  • Jennifer A. Wargo

    (Medical Oncology and Dermatology, Massachusetts General Hospital, 55 Fruit Street, Boston, Massachusetts 02114, USA)

  • Todd R. Golub

    (The Eli and Edythe L. Broad Institute, 7 Cambridge Center
    Dana-Farber Cancer Institute, 44 Binney Street, Boston, Massachusetts 02115, USA
    Harvard Medical School
    Howard Hughes Medical Institute)

Abstract

The secretion of hepatocyte growth factor by stromal cells in the tumour micro-environment can make melanoma resistant to RAF inhibitors, through the activation of the MET signalling pathway, but a combination of RAF and MET inhibitors can overcome this resistance.

Suggested Citation

  • Ravid Straussman & Teppei Morikawa & Kevin Shee & Michal Barzily-Rokni & Zhi Rong Qian & Jinyan Du & Ashli Davis & Margaret M. Mongare & Joshua Gould & Dennie T. Frederick & Zachary A. Cooper & Paul B, 2012. "Tumour micro-environment elicits innate resistance to RAF inhibitors through HGF secretion," Nature, Nature, vol. 487(7408), pages 500-504, July.
    • Handle: RePEc:nat:nature:v:487:y:2012:i:7408:d:10.1038_nature11183
    DOI: 10.1038/nature11183
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    Cited by:

    1. Jiaxin Liang & Deyang Yu & Chi Luo & Christopher Bennett & Mark Jedrychowski & Steve P. Gygi & Hans R. Widlund & Pere Puigserver, 2023. "Epigenetic suppression of PGC1α (PPARGC1A) causes collateral sensitivity to HMGCR-inhibitors within BRAF-treatment resistant melanomas," Nature Communications, Nature, vol. 14(1), pages 1-12, December.
    2. Naomi Kawashima & Yuichi Ishikawa & Jeong Hui Kim & Yoko Ushijima & Akimi Akashi & Yohei Yamaguchi & Hikaru Hattori & Marie Nakashima & Seara Ikeno & Rika Kihara & Takahiro Nishiyama & Takanobu Morish, 2022. "Comparison of clonal architecture between primary and immunodeficient mouse-engrafted acute myeloid leukemia cells," Nature Communications, Nature, vol. 13(1), pages 1-11, December.
    3. Daniel E Carlin & Barry Demchak & Dexter Pratt & Eric Sage & Trey Ideker, 2017. "Network propagation in the cytoscape cyberinfrastructure," PLOS Computational Biology, Public Library of Science, vol. 13(10), pages 1-9, October.
    4. David Gonzalez-Martinez & Lee Roth & Thomas R. Mumford & Juan Guan & Anh Le & Robert C. Doebele & Bo Huang & Asmin Tulpule & Magdalena Niewiadomska-Bugaj & Trever G. Bivona & Lukasz J. Bugaj, 2024. "Oncogenic EML4-ALK assemblies suppress growth factor perception and modulate drug tolerance," Nature Communications, Nature, vol. 15(1), pages 1-17, December.

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