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Tracing the origins of relapse in acute myeloid leukaemia to stem cells

Author

Listed:
  • Liran I. Shlush

    (Princess Margaret Cancer Centre, University Health Network
    Weizmann Institute of Science
    Division of Hematology Rambam Healthcare Campus)

  • Amanda Mitchell

    (Princess Margaret Cancer Centre, University Health Network)

  • Lawrence Heisler

    (Ontario Institute for Cancer Research)

  • Sagi Abelson

    (Princess Margaret Cancer Centre, University Health Network)

  • Stanley W. K. Ng

    (Princess Margaret Cancer Centre, University Health Network)

  • Aaron Trotman-Grant

    (Princess Margaret Cancer Centre, University Health Network)

  • Jessie J. F. Medeiros

    (Princess Margaret Cancer Centre, University Health Network)

  • Abilasha Rao-Bhatia

    (Princess Margaret Cancer Centre, University Health Network)

  • Ivana Jaciw-Zurakowsky

    (Princess Margaret Cancer Centre, University Health Network)

  • Rene Marke

    (Laboratory of Pediatric Oncology, Radboud University Medical Center)

  • Jessica L. McLeod

    (Princess Margaret Cancer Centre, University Health Network)

  • Monica Doedens

    (Princess Margaret Cancer Centre, University Health Network)

  • Gary Bader

    (University of Toronto
    Donnelly Centre for Cellular and Biomolecular Research)

  • Veronique Voisin

    (Donnelly Centre for Cellular and Biomolecular Research)

  • ChangJiang Xu

    (Donnelly Centre for Cellular and Biomolecular Research)

  • John D. McPherson

    (Ontario Institute for Cancer Research)

  • Thomas J. Hudson

    (Ontario Institute for Cancer Research
    University of Toronto
    University of Toronto)

  • Jean C. Y. Wang

    (Princess Margaret Cancer Centre, University Health Network
    University of Toronto
    University Health Network)

  • Mark D. Minden

    (Princess Margaret Cancer Centre, University Health Network
    University of Toronto
    University of Toronto
    University Health Network)

  • John E. Dick

    (Princess Margaret Cancer Centre, University Health Network
    University of Toronto)

Abstract

Identification of the cell types from which relapse arises in acute myeloid leukaemia, by following leukaemia propagation from patient-derived leukaemia samples.

Suggested Citation

  • Liran I. Shlush & Amanda Mitchell & Lawrence Heisler & Sagi Abelson & Stanley W. K. Ng & Aaron Trotman-Grant & Jessie J. F. Medeiros & Abilasha Rao-Bhatia & Ivana Jaciw-Zurakowsky & Rene Marke & Jessi, 2017. "Tracing the origins of relapse in acute myeloid leukaemia to stem cells," Nature, Nature, vol. 547(7661), pages 104-108, July.
    • Handle: RePEc:nat:nature:v:547:y:2017:i:7661:d:10.1038_nature22993
    DOI: 10.1038/nature22993
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    Cited by:

    1. Naomi Kawashima & Yuichi Ishikawa & Jeong Hui Kim & Yoko Ushijima & Akimi Akashi & Yohei Yamaguchi & Hikaru Hattori & Marie Nakashima & Seara Ikeno & Rika Kihara & Takahiro Nishiyama & Takanobu Morish, 2022. "Comparison of clonal architecture between primary and immunodeficient mouse-engrafted acute myeloid leukemia cells," Nature Communications, Nature, vol. 13(1), pages 1-11, December.
    2. N. Zioni & A. Akhiad Bercovich & N. Chapal-Ilani & Tal Bacharach & N. Rappoport & A. Solomon & R. Avraham & E. Kopitman & Z. Porat & M. Sacma & G. Hartmut & M. Scheller & C. Muller-Tidow & D. Lipka & , 2023. "Inflammatory signals from fatty bone marrow support DNMT3A driven clonal hematopoiesis," Nature Communications, Nature, vol. 14(1), pages 1-17, December.
    3. Jenny Karlsson & Hiroaki Yasui & Adriana Mañas & Natalie Andersson & Karin Hansson & Kristina Aaltonen & Caroline Jansson & Geoffroy Durand & Naveen Ravi & Michele Ferro & Minjun Yang & Subhayan Chatt, 2024. "Early evolutionary branching across spatial domains predisposes to clonal replacement under chemotherapy in neuroblastoma," Nature Communications, Nature, vol. 15(1), pages 1-19, December.
    4. Matteo Maria Naldini & Gabriele Casirati & Matteo Barcella & Paola Maria Vittoria Rancoita & Andrea Cosentino & Carolina Caserta & Francesca Pavesi & Erika Zonari & Giacomo Desantis & Diego Gilioli & , 2023. "Longitudinal single-cell profiling of chemotherapy response in acute myeloid leukemia," Nature Communications, Nature, vol. 14(1), pages 1-20, December.

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