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Clonal evolution in relapsed acute myeloid leukaemia revealed by whole-genome sequencing

Author

Listed:
  • Li Ding

    (The Genome Institute, Washington University
    Washington University)

  • Timothy J. Ley

    (The Genome Institute, Washington University
    Washington University
    Siteman Cancer Center, Washington University)

  • David E. Larson

    (The Genome Institute, Washington University)

  • Christopher A. Miller

    (The Genome Institute, Washington University)

  • Daniel C. Koboldt

    (The Genome Institute, Washington University)

  • John S. Welch

    (Washington University)

  • Julie K. Ritchey

    (Washington University)

  • Margaret A. Young

    (Washington University)

  • Tamara Lamprecht

    (Washington University)

  • Michael D. McLellan

    (The Genome Institute, Washington University)

  • Joshua F. McMichael

    (The Genome Institute, Washington University)

  • John W. Wallis

    (The Genome Institute, Washington University
    Washington University)

  • Charles Lu

    (The Genome Institute, Washington University)

  • Dong Shen

    (The Genome Institute, Washington University)

  • Christopher C. Harris

    (The Genome Institute, Washington University)

  • David J. Dooling

    (The Genome Institute, Washington University
    Washington University)

  • Robert S. Fulton

    (The Genome Institute, Washington University
    Washington University)

  • Lucinda L. Fulton

    (The Genome Institute, Washington University
    Washington University)

  • Ken Chen

    (The Genome Institute, Washington University
    Washington University)

  • Heather Schmidt

    (The Genome Institute, Washington University)

  • Joelle Kalicki-Veizer

    (The Genome Institute, Washington University)

  • Vincent J. Magrini

    (The Genome Institute, Washington University
    Washington University)

  • Lisa Cook

    (The Genome Institute, Washington University)

  • Sean D. McGrath

    (The Genome Institute, Washington University)

  • Tammi L. Vickery

    (The Genome Institute, Washington University)

  • Michael C. Wendl

    (The Genome Institute, Washington University
    Washington University)

  • Sharon Heath

    (Washington University)

  • Mark A. Watson

    (Washington University)

  • Daniel C. Link

    (Washington University
    Siteman Cancer Center, Washington University)

  • Michael H. Tomasson

    (Washington University
    Siteman Cancer Center, Washington University)

  • William D. Shannon

    (Washington University)

  • Jacqueline E. Payton

    (Washington University)

  • Shashikant Kulkarni

    (Washington University
    Siteman Cancer Center, Washington University
    Washington University)

  • Peter Westervelt

    (Washington University
    Siteman Cancer Center, Washington University)

  • Matthew J. Walter

    (Washington University
    Siteman Cancer Center, Washington University)

  • Timothy A. Graubert

    (Washington University
    Siteman Cancer Center, Washington University)

  • Elaine R. Mardis

    (The Genome Institute, Washington University
    Washington University
    Siteman Cancer Center, Washington University)

  • Richard K. Wilson

    (The Genome Institute, Washington University
    Washington University
    Siteman Cancer Center, Washington University)

  • John F. DiPersio

    (Washington University
    Siteman Cancer Center, Washington University)

Abstract

The sequencing of AML genomes of eight patients before and after relapse reveals two major patterns of clonal evolution, with chemotherapy appearing to have a role in both patterns.

Suggested Citation

  • Li Ding & Timothy J. Ley & David E. Larson & Christopher A. Miller & Daniel C. Koboldt & John S. Welch & Julie K. Ritchey & Margaret A. Young & Tamara Lamprecht & Michael D. McLellan & Joshua F. McMic, 2012. "Clonal evolution in relapsed acute myeloid leukaemia revealed by whole-genome sequencing," Nature, Nature, vol. 481(7382), pages 506-510, January.
    • Handle: RePEc:nat:nature:v:481:y:2012:i:7382:d:10.1038_nature10738
    DOI: 10.1038/nature10738
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    Citations

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    Cited by:

    1. Seong-Hwan Jun & Hosein Toosi & Jeff Mold & Camilla Engblom & Xinsong Chen & Ciara O’Flanagan & Michael Hagemann-Jensen & Rickard Sandberg & Samuel Aparicio & Johan Hartman & Andrew Roth & Jens Lagerg, 2023. "Reconstructing clonal tree for phylo-phenotypic characterization of cancer using single-cell transcriptomics," Nature Communications, Nature, vol. 14(1), pages 1-16, December.
    2. Qilin Zhang & Ziyan Xu & Rui Han & Yunzhi Wang & Zhen Ye & Jiajun Zhu & Yixin Cai & Fan Zhang & Jiangyan Zhao & Boyuan Yao & Zhaoyu Qin & Nidan Qiao & Ruofan Huang & Jinwen Feng & Yongfei Wang & Wenti, 2024. "Proteogenomic characterization of skull-base chordoma," Nature Communications, Nature, vol. 15(1), pages 1-32, December.
    3. Humberto Contreras-Trujillo & Jiya Eerdeng & Samir Akre & Du Jiang & Jorge Contreras & Basia Gala & Mary C. Vergel-Rodriguez & Yeachan Lee & Aparna Jorapur & Areen Andreasian & Lisa Harton & Charles S, 2021. "Deciphering intratumoral heterogeneity using integrated clonal tracking and single-cell transcriptome analyses," Nature Communications, Nature, vol. 12(1), pages 1-14, December.
    4. Naomi Kawashima & Yuichi Ishikawa & Jeong Hui Kim & Yoko Ushijima & Akimi Akashi & Yohei Yamaguchi & Hikaru Hattori & Marie Nakashima & Seara Ikeno & Rika Kihara & Takahiro Nishiyama & Takanobu Morish, 2022. "Comparison of clonal architecture between primary and immunodeficient mouse-engrafted acute myeloid leukemia cells," Nature Communications, Nature, vol. 13(1), pages 1-11, December.
    5. Ting Liu & Jianan Rao & Wenting Hu & Bowen Cui & Jiaoyang Cai & Yuhan Liu & Huiying Sun & Xiaoxiao Chen & Yanjing Tang & Jing Chen & Xiang Wang & Han Wang & Wubin Qian & Binchen Mao & Sheng Guo & Rong, 2022. "Distinct genomic landscape of Chinese pediatric acute myeloid leukemia impacts clinical risk classification," Nature Communications, Nature, vol. 13(1), pages 1-11, December.
    6. Matteo Maria Naldini & Gabriele Casirati & Matteo Barcella & Paola Maria Vittoria Rancoita & Andrea Cosentino & Carolina Caserta & Francesca Pavesi & Erika Zonari & Giacomo Desantis & Diego Gilioli & , 2023. "Longitudinal single-cell profiling of chemotherapy response in acute myeloid leukemia," Nature Communications, Nature, vol. 14(1), pages 1-20, December.
    7. Dan Daniel Erdmann-Pham & Sanjit Singh Batra & Timothy K. Turkalo & James Durbin & Marco Blanchette & Iwei Yeh & Hunter Shain & Boris C. Bastian & Yun S. Song & Daniel S. Rokhsar & Dirk Hockemeyer, 2023. "Tracing cancer evolution and heterogeneity using Hi-C," Nature Communications, Nature, vol. 14(1), pages 1-17, December.

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