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Dynamics of genomic clones in breast cancer patient xenografts at single-cell resolution

Author

Listed:
  • Peter Eirew

    (BC Cancer Agency, 675 West 10th Avenue, Vancouver, British Columbia V5Z 1L3, Canada
    University of British Columbia, Vancouver, British Columbia V6T 2B5, Canada)

  • Adi Steif

    (BC Cancer Agency, 675 West 10th Avenue, Vancouver, British Columbia V5Z 1L3, Canada
    University of British Columbia, Vancouver, British Columbia V6T 2B5, Canada)

  • Jaswinder Khattra

    (BC Cancer Agency, 675 West 10th Avenue, Vancouver, British Columbia V5Z 1L3, Canada
    University of British Columbia, Vancouver, British Columbia V6T 2B5, Canada)

  • Gavin Ha

    (BC Cancer Agency, 675 West 10th Avenue, Vancouver, British Columbia V5Z 1L3, Canada
    University of British Columbia, Vancouver, British Columbia V6T 2B5, Canada)

  • Damian Yap

    (BC Cancer Agency, 675 West 10th Avenue, Vancouver, British Columbia V5Z 1L3, Canada
    University of British Columbia, Vancouver, British Columbia V6T 2B5, Canada)

  • Hossein Farahani

    (BC Cancer Agency, 675 West 10th Avenue, Vancouver, British Columbia V5Z 1L3, Canada
    University of British Columbia, Vancouver, British Columbia V6T 2B5, Canada)

  • Karen Gelmon

    (BC Cancer Agency, 600 West 10th Avenue, Vancouver, British Columbia V5Z 4E6, Canada)

  • Stephen Chia

    (BC Cancer Agency, 600 West 10th Avenue, Vancouver, British Columbia V5Z 4E6, Canada)

  • Colin Mar

    (BC Cancer Agency, 600 West 10th Avenue, Vancouver, British Columbia V5Z 4E6, Canada)

  • Adrian Wan

    (BC Cancer Agency, 675 West 10th Avenue, Vancouver, British Columbia V5Z 1L3, Canada)

  • Emma Laks

    (BC Cancer Agency, 675 West 10th Avenue, Vancouver, British Columbia V5Z 1L3, Canada
    University of British Columbia, Vancouver, British Columbia V6T 2B5, Canada)

  • Justina Biele

    (BC Cancer Agency, 675 West 10th Avenue, Vancouver, British Columbia V5Z 1L3, Canada
    University of British Columbia, Vancouver, British Columbia V6T 2B5, Canada)

  • Karey Shumansky

    (BC Cancer Agency, 675 West 10th Avenue, Vancouver, British Columbia V5Z 1L3, Canada)

  • Jamie Rosner

    (BC Cancer Agency, 675 West 10th Avenue, Vancouver, British Columbia V5Z 1L3, Canada)

  • Andrew McPherson

    (BC Cancer Agency, 675 West 10th Avenue, Vancouver, British Columbia V5Z 1L3, Canada
    University of British Columbia, Vancouver, British Columbia V6T 2B5, Canada)

  • Cydney Nielsen

    (BC Cancer Agency, 675 West 10th Avenue, Vancouver, British Columbia V5Z 1L3, Canada
    University of British Columbia, Vancouver, British Columbia V6T 2B5, Canada)

  • Andrew J. L. Roth

    (BC Cancer Agency, 675 West 10th Avenue, Vancouver, British Columbia V5Z 1L3, Canada
    University of British Columbia, Vancouver, British Columbia V6T 2B5, Canada)

  • Calvin Lefebvre

    (BC Cancer Agency, 675 West 10th Avenue, Vancouver, British Columbia V5Z 1L3, Canada
    University of British Columbia, Vancouver, British Columbia V6T 2B5, Canada)

  • Ali Bashashati

    (BC Cancer Agency, 675 West 10th Avenue, Vancouver, British Columbia V5Z 1L3, Canada
    University of British Columbia, Vancouver, British Columbia V6T 2B5, Canada)

  • Camila de Souza

    (BC Cancer Agency, 675 West 10th Avenue, Vancouver, British Columbia V5Z 1L3, Canada)

  • Celia Siu

    (BC Cancer Agency, 675 West 10th Avenue, Vancouver, British Columbia V5Z 1L3, Canada)

  • Radhouane Aniba

    (BC Cancer Agency, 675 West 10th Avenue, Vancouver, British Columbia V5Z 1L3, Canada
    University of British Columbia, Vancouver, British Columbia V6T 2B5, Canada)

  • Jazmine Brimhall

    (BC Cancer Agency, 675 West 10th Avenue, Vancouver, British Columbia V5Z 1L3, Canada)

  • Arusha Oloumi

    (BC Cancer Agency, 675 West 10th Avenue, Vancouver, British Columbia V5Z 1L3, Canada
    University of British Columbia, Vancouver, British Columbia V6T 2B5, Canada)

  • Tomo Osako

    (BC Cancer Agency, 675 West 10th Avenue, Vancouver, British Columbia V5Z 1L3, Canada
    University of British Columbia, Vancouver, British Columbia V6T 2B5, Canada)

  • Alejandra Bruna

    (University of Cambridge, Hills Road, Cambridge CB2 2XZ, UK
    Cancer Research UK Cambridge Research Institute, University of Cambridge, Li Ka Shing Centre, Cambridge CB2 0RE, UK)

  • Jose L. Sandoval

    (University of Cambridge, Hills Road, Cambridge CB2 2XZ, UK
    Cancer Research UK Cambridge Research Institute, University of Cambridge, Li Ka Shing Centre, Cambridge CB2 0RE, UK)

  • Teresa Algara

    (BC Cancer Agency, 675 West 10th Avenue, Vancouver, British Columbia V5Z 1L3, Canada
    University of British Columbia, Vancouver, British Columbia V6T 2B5, Canada)

  • Wendy Greenwood

    (University of Cambridge, Hills Road, Cambridge CB2 2XZ, UK
    Cancer Research UK Cambridge Research Institute, University of Cambridge, Li Ka Shing Centre, Cambridge CB2 0RE, UK)

  • Kaston Leung

    (Centre for High-Throughput Biology, University of British Columbia, Vancouver, British Columbia V6T 1Z4, Canada
    University of British Columbia, Vancouver, British Columbia V6T 1Z1, Canada)

  • Hongwei Cheng

    (BC Cancer Agency, 675 West 10th Avenue, Vancouver, British Columbia V5Z 1L3, Canada
    The Vancouver Prostate Centre, University of British Columbia, Vancouver, British Columbia V5Z 1M9, Canada)

  • Hui Xue

    (BC Cancer Agency, 675 West 10th Avenue, Vancouver, British Columbia V5Z 1L3, Canada
    The Vancouver Prostate Centre, University of British Columbia, Vancouver, British Columbia V5Z 1M9, Canada)

  • Yuzhuo Wang

    (BC Cancer Agency, 675 West 10th Avenue, Vancouver, British Columbia V5Z 1L3, Canada
    The Vancouver Prostate Centre, University of British Columbia, Vancouver, British Columbia V5Z 1M9, Canada)

  • Dong Lin

    (BC Cancer Agency, 675 West 10th Avenue, Vancouver, British Columbia V5Z 1L3, Canada
    The Vancouver Prostate Centre, University of British Columbia, Vancouver, British Columbia V5Z 1M9, Canada)

  • Andrew J. Mungall

    (Michael Smith Genome Sciences Centre, Vancouver, British Columbia V5Z 1L3, Canada)

  • Richard Moore

    (Michael Smith Genome Sciences Centre, Vancouver, British Columbia V5Z 1L3, Canada)

  • Yongjun Zhao

    (Michael Smith Genome Sciences Centre, Vancouver, British Columbia V5Z 1L3, Canada)

  • Julie Lorette

    (Centre for Translational and Applied Genomics, BC Cancer Agency, 600 West 10th Avenue, Vancouver, British Columbia V5Z 4E6, Canada)

  • Long Nguyen

    (University of British Columbia, Vancouver, British Columbia V6T 1Z3, Canada
    Terry Fox Laboratory, BC Cancer Agency, Vancouver, British Columbia V5Z 1L3, Canada)

  • David Huntsman

    (University of British Columbia, Vancouver, British Columbia V6T 2B5, Canada
    Centre for Translational and Applied Genomics, BC Cancer Agency, 600 West 10th Avenue, Vancouver, British Columbia V5Z 4E6, Canada)

  • Connie J. Eaves

    (University of British Columbia, Vancouver, British Columbia V6T 1Z3, Canada
    Terry Fox Laboratory, BC Cancer Agency, Vancouver, British Columbia V5Z 1L3, Canada)

  • Carl Hansen

    (Centre for High-Throughput Biology, University of British Columbia, Vancouver, British Columbia V6T 1Z4, Canada
    University of British Columbia, Vancouver, British Columbia V6T 1Z1, Canada)

  • Marco A. Marra

    (Michael Smith Genome Sciences Centre, Vancouver, British Columbia V5Z 1L3, Canada)

  • Carlos Caldas

    (University of Cambridge, Hills Road, Cambridge CB2 2XZ, UK
    Cancer Research UK Cambridge Research Institute, University of Cambridge, Li Ka Shing Centre, Cambridge CB2 0RE, UK)

  • Sohrab P. Shah

    (BC Cancer Agency, 675 West 10th Avenue, Vancouver, British Columbia V5Z 1L3, Canada
    University of British Columbia, Vancouver, British Columbia V6T 2B5, Canada
    Michael Smith Genome Sciences Centre, Vancouver, British Columbia V5Z 1L3, Canada)

  • Samuel Aparicio

    (BC Cancer Agency, 675 West 10th Avenue, Vancouver, British Columbia V5Z 1L3, Canada
    University of British Columbia, Vancouver, British Columbia V6T 2B5, Canada
    Michael Smith Genome Sciences Centre, Vancouver, British Columbia V5Z 1L3, Canada
    Centre for Translational and Applied Genomics, BC Cancer Agency, 600 West 10th Avenue, Vancouver, British Columbia V5Z 4E6, Canada)

Abstract

Deep-genome and single-cell sequencing analyses of patient-derived breast cancer xenografts reveal extensive, dynamic and reproducible changes in intra-tumoral mutational clonal composition on engraftment and serial propagation.

Suggested Citation

  • Peter Eirew & Adi Steif & Jaswinder Khattra & Gavin Ha & Damian Yap & Hossein Farahani & Karen Gelmon & Stephen Chia & Colin Mar & Adrian Wan & Emma Laks & Justina Biele & Karey Shumansky & Jamie Rosn, 2015. "Dynamics of genomic clones in breast cancer patient xenografts at single-cell resolution," Nature, Nature, vol. 518(7539), pages 422-426, February.
    • Handle: RePEc:nat:nature:v:518:y:2015:i:7539:d:10.1038_nature13952
    DOI: 10.1038/nature13952
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    Citations

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    Cited by:

    1. Hari Shankar Sunil & Kathryn A. O’Donnell, 2024. "Capturing heterogeneity in PDX models: representation matters," Nature Communications, Nature, vol. 15(1), pages 1-3, December.
    2. Humberto Contreras-Trujillo & Jiya Eerdeng & Samir Akre & Du Jiang & Jorge Contreras & Basia Gala & Mary C. Vergel-Rodriguez & Yeachan Lee & Aparna Jorapur & Areen Andreasian & Lisa Harton & Charles S, 2021. "Deciphering intratumoral heterogeneity using integrated clonal tracking and single-cell transcriptome analyses," Nature Communications, Nature, vol. 12(1), pages 1-14, December.
    3. Naomi Kawashima & Yuichi Ishikawa & Jeong Hui Kim & Yoko Ushijima & Akimi Akashi & Yohei Yamaguchi & Hikaru Hattori & Marie Nakashima & Seara Ikeno & Rika Kihara & Takahiro Nishiyama & Takanobu Morish, 2022. "Comparison of clonal architecture between primary and immunodeficient mouse-engrafted acute myeloid leukemia cells," Nature Communications, Nature, vol. 13(1), pages 1-11, December.
    4. Robert E. Hynds & Ariana Huebner & David R. Pearce & Mark S. Hill & Ayse U. Akarca & David A. Moore & Sophia Ward & Kate H. C. Gowers & Takahiro Karasaki & Maise Al Bakir & Gareth A. Wilson & Oriol Pi, 2024. "Representation of genomic intratumor heterogeneity in multi-region non-small cell lung cancer patient-derived xenograft models," Nature Communications, Nature, vol. 15(1), pages 1-21, December.
    5. Peter Eirew & Ciara O’Flanagan & Jerome Ting & Sohrab Salehi & Jazmine Brimhall & Beixi Wang & Justina Biele & Teresa Algara & So Ra Lee & Corey Hoang & Damian Yap & Steven McKinney & Cherie Bates & E, 2022. "Accurate determination of CRISPR-mediated gene fitness in transplantable tumours," Nature Communications, Nature, vol. 13(1), pages 1-19, December.
    6. Qiuchen Guo & Milos Spasic & Adam G. Maynard & Gregory J. Goreczny & Amanuel Bizuayehu & Jessica F. Olive & Peter Galen & Sandra S. McAllister, 2022. "Clonal barcoding with qPCR detection enables live cell functional analyses for cancer research," Nature Communications, Nature, vol. 13(1), pages 1-15, December.

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