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Neuronal activity in sensory cortex predicts the specificity of learning in mice

Author

Listed:
  • Katherine C. Wood

    (University of Pennsylvania)

  • Christopher F. Angeloni

    (University of Pennsylvania
    University of Pennsylvania)

  • Karmi Oxman

    (University of Pennsylvania)

  • Claudia Clopath

    (Imperial College London)

  • Maria N. Geffen

    (University of Pennsylvania
    University of Pennsylvania
    University of Pennsylvania)

Abstract

Learning to avoid dangerous signals while preserving normal responses to safe stimuli is essential for everyday behavior and survival. Following identical experiences, subjects exhibit fear specificity ranging from high (specializing fear to only the dangerous stimulus) to low (generalizing fear to safe stimuli), yet the neuronal basis of fear specificity remains unknown. Here, we identified the neuronal code that underlies inter-subject variability in fear specificity using longitudinal imaging of neuronal activity before and after differential fear conditioning in the auditory cortex of mice. Neuronal activity prior to, but not after learning predicted the level of specificity following fear conditioning across subjects. Stimulus representation in auditory cortex was reorganized following conditioning. However, the reorganized neuronal activity did not relate to the specificity of learning. These results present a novel neuronal code that determines individual patterns in learning.

Suggested Citation

  • Katherine C. Wood & Christopher F. Angeloni & Karmi Oxman & Claudia Clopath & Maria N. Geffen, 2022. "Neuronal activity in sensory cortex predicts the specificity of learning in mice," Nature Communications, Nature, vol. 13(1), pages 1-15, December.
    • Handle: RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-022-28784-w
    DOI: 10.1038/s41467-022-28784-w
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    References listed on IDEAS

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    1. Dion, Michelle L. & Sumner, Jane Lawrence & Mitchell, Sara McLaughlin, 2018. "Gendered Citation Patterns across Political Science and Social Science Methodology Fields," Political Analysis, Cambridge University Press, vol. 26(3), pages 312-327, July.
    2. Caroline A. Runyan & Eugenio Piasini & Stefano Panzeri & Christopher D. Harvey, 2017. "Distinct timescales of population coding across cortex," Nature, Nature, vol. 548(7665), pages 92-96, August.
    3. Jennifer M. Blackwell & Maria N. Geffen, 2017. "Progress and challenges for understanding the function of cortical microcircuits in auditory processing," Nature Communications, Nature, vol. 8(1), pages 1-9, December.
    4. Maliniak, Daniel & Powers, Ryan & Walter, Barbara F., 2013. "The Gender Citation Gap in International Relations," International Organization, Cambridge University Press, vol. 67(4), pages 889-922, October.
    5. Johannes J. Letzkus & Steffen B. E. Wolff & Elisabeth M. M. Meyer & Philip Tovote & Julien Courtin & Cyril Herry & Andreas Lüthi, 2011. "A disinhibitory microcircuit for associative fear learning in the auditory cortex," Nature, Nature, vol. 480(7377), pages 331-335, December.
    6. Richard F Betzel & Katherine C Wood & Christopher Angeloni & Maria Neimark Geffen & Danielle S Bassett, 2019. "Stability of spontaneous, correlated activity in mouse auditory cortex," PLOS Computational Biology, Public Library of Science, vol. 15(12), pages 1-25, December.
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