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The gut hormone Allatostatin C/Somatostatin regulates food intake and metabolic homeostasis under nutrient stress

Author

Listed:
  • Olga Kubrak

    (University of Copenhagen)

  • Takashi Koyama

    (University of Copenhagen)

  • Nadja Ahrentløv

    (University of Copenhagen)

  • Line Jensen

    (University of Copenhagen)

  • Alina Malita

    (University of Copenhagen)

  • Muhammad T. Naseem

    (University of Copenhagen)

  • Mette Lassen

    (University of Copenhagen)

  • Stanislav Nagy

    (University of Copenhagen)

  • Michael J. Texada

    (University of Copenhagen)

  • Kenneth V. Halberg

    (University of Copenhagen)

  • Kim Rewitz

    (University of Copenhagen)

Abstract

The intestine is a central regulator of metabolic homeostasis. Dietary inputs are absorbed through the gut, which senses their nutritional value and relays hormonal information to other organs to coordinate systemic energy balance. However, the gut-derived hormones affecting metabolic and behavioral responses are poorly defined. Here we show that the endocrine cells of the Drosophila gut sense nutrient stress through a mechanism that involves the TOR pathway and in response secrete the peptide hormone allatostatin C, a Drosophila somatostatin homolog. Gut-derived allatostatin C induces secretion of glucagon-like adipokinetic hormone to coordinate food intake and energy mobilization. Loss of gut Allatostatin C or its receptor in the adipokinetic-hormone-producing cells impairs lipid and sugar mobilization during fasting, leading to hypoglycemia. Our findings illustrate a nutrient-responsive endocrine mechanism that maintains energy homeostasis under nutrient-stress conditions, a function that is essential to health and whose failure can lead to metabolic disorders.

Suggested Citation

  • Olga Kubrak & Takashi Koyama & Nadja Ahrentløv & Line Jensen & Alina Malita & Muhammad T. Naseem & Mette Lassen & Stanislav Nagy & Michael J. Texada & Kenneth V. Halberg & Kim Rewitz, 2022. "The gut hormone Allatostatin C/Somatostatin regulates food intake and metabolic homeostasis under nutrient stress," Nature Communications, Nature, vol. 13(1), pages 1-17, December.
    • Handle: RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-022-28268-x
    DOI: 10.1038/s41467-022-28268-x
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    References listed on IDEAS

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    Cited by:

    1. Chen Zhang & Anmo J. Kim & Crisalesandra Rivera-Perez & Fernando G. Noriega & Young-Joon Kim, 2022. "The insect somatostatin pathway gates vitellogenesis progression during reproductive maturation and the post-mating response," Nature Communications, Nature, vol. 13(1), pages 1-15, December.
    2. Kübra Kahveci & Mustafa Barbaros Düzgün & Abdullah Emre Atis & Abdullah Yılmaz & Aida Shahraki & Basak Coskun & Serdar Durdagi & Necla Birgul Iyison, 2024. "Discovering allatostatin type-C receptor specific agonists," Nature Communications, Nature, vol. 15(1), pages 1-15, December.
    3. Olga Kubrak & Anne F. Jørgensen & Takashi Koyama & Mette Lassen & Stanislav Nagy & Jacob Hald & Gianluca Mazzoni & Dennis Madsen & Jacob B. Hansen & Martin Røssel Larsen & Michael J. Texada & Jakob L., 2024. "LGR signaling mediates muscle-adipose tissue crosstalk and protects against diet-induced insulin resistance," Nature Communications, Nature, vol. 15(1), pages 1-22, December.
    4. Junjun Gao & Song Zhang & Pan Deng & Zhigang Wu & Bruno Lemaitre & Zongzhao Zhai & Zheng Guo, 2024. "Dietary L-Glu sensing by enteroendocrine cells adjusts food intake via modulating gut PYY/NPF secretion," Nature Communications, Nature, vol. 15(1), pages 1-22, December.

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