IDEAS home Printed from https://ideas.repec.org/a/nat/natcom/v12y2021i1d10.1038_s41467-021-25786-y.html
   My bibliography  Save this article

ATP-citrate lyase promotes axonal transport across species

Author

Listed:
  • Aviel Even

    (Tel Aviv University)

  • Giovanni Morelli

    (University of Liège, C.H.U. Sart Tilman
    BIOMED Research Institute)

  • Silvia Turchetto

    (University of Liège, C.H.U. Sart Tilman)

  • Michal Shilian

    (Tel Aviv University)

  • Romain Le Bail

    (University of Liège, C.H.U. Sart Tilman)

  • Sophie Laguesse

    (University of Liège, C.H.U. Sart Tilman)

  • Nathalie Krusy

    (University of Liège, C.H.U. Sart Tilman)

  • Ariel Brisker

    (Tel Aviv University)

  • Alexander Brandis

    (Life Sciences Core Facilities, Weizmann Institute of Science)

  • Shani Inbar

    (Tel Aviv University)

  • Alain Chariot

    (University of Liège, C.H.U. Sart Tilman)

  • Frédéric Saudou

    (Univ. Grenoble Alpes, Inserm, U1216, CHU Grenoble Alpes, Grenoble Institut Neurosciences
    Inserm, U1216
    CHU Grenoble Alpes)

  • Paula Dietrich

    (University of Tennessee Health Science Center)

  • Ioannis Dragatsis

    (University of Tennessee Health Science Center)

  • Bert Brone

    (BIOMED Research Institute)

  • Loïc Broix

    (University of Liège, C.H.U. Sart Tilman)

  • Jean-Michel Rigo

    (BIOMED Research Institute)

  • Miguel Weil

    (Tel Aviv University)

  • Laurent Nguyen

    (University of Liège, C.H.U. Sart Tilman)

Abstract

Microtubule (MT)-based transport is an evolutionary conserved process finely tuned by posttranslational modifications. Among them, α-tubulin acetylation, primarily catalyzed by a vesicular pool of α-tubulin N-acetyltransferase 1 (Atat1), promotes the recruitment and processivity of molecular motors along MT tracks. However, the mechanism that controls Atat1 activity remains poorly understood. Here, we show that ATP-citrate lyase (Acly) is enriched in vesicles and provide Acetyl-Coenzyme-A (Acetyl-CoA) to Atat1. In addition, we showed that Acly expression is reduced upon loss of Elongator activity, further connecting Elongator to Atat1 in a pathway regulating α-tubulin acetylation and MT-dependent transport in projection neurons, across species. Remarkably, comparable defects occur in fibroblasts from Familial Dysautonomia (FD) patients bearing an autosomal recessive mutation in the gene coding for the Elongator subunit ELP1. Our data may thus shine light on the pathophysiological mechanisms underlying FD.

Suggested Citation

  • Aviel Even & Giovanni Morelli & Silvia Turchetto & Michal Shilian & Romain Le Bail & Sophie Laguesse & Nathalie Krusy & Ariel Brisker & Alexander Brandis & Shani Inbar & Alain Chariot & Frédéric Saudo, 2021. "ATP-citrate lyase promotes axonal transport across species," Nature Communications, Nature, vol. 12(1), pages 1-14, December.
  • Handle: RePEc:nat:natcom:v:12:y:2021:i:1:d:10.1038_s41467-021-25786-y
    DOI: 10.1038/s41467-021-25786-y
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/s41467-021-25786-y
    File Function: Abstract
    Download Restriction: no

    File URL: https://libkey.io/10.1038/s41467-021-25786-y?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    References listed on IDEAS

    as
    1. Vinay K. Godena & Nicholas Brookes-Hocking & Annekathrin Moller & Gary Shaw & Matthew Oswald & Rosa M. Sancho & Christopher C. J. Miller & Alexander J. Whitworth & Kurt J. De Vos, 2014. "Increasing microtubule acetylation rescues axonal transport and locomotor deficits caused by LRRK2 Roc-COR domain mutations," Nature Communications, Nature, vol. 5(1), pages 1-11, December.
    2. Marija Kojic & Monika Gaik & Bence Kiska & Anna Salerno-Kochan & Sarah Hunt & Angelo Tedoldi & Sergey Mureev & Alun Jones & Belinda Whittle & Laura A. Genovesi & Christelle Adolphe & Darren L. Brown &, 2018. "Elongator mutation in mice induces neurodegeneration and ataxia-like behavior," Nature Communications, Nature, vol. 9(1), pages 1-13, December.
    3. Ting-Yu Lin & Nour El Hana Abbassi & Karol Zakrzewski & Andrzej Chramiec-Głąbik & Małgorzata Jemioła-Rzemińska & Jan Różycki & Sebastian Glatt, 2019. "The Elongator subunit Elp3 is a non-canonical tRNA acetyltransferase," Nature Communications, Nature, vol. 10(1), pages 1-12, December.
    4. Charlotte Hubbert & Amaris Guardiola & Rong Shao & Yoshiharu Kawaguchi & Akihiro Ito & Andrew Nixon & Minoru Yoshida & Xiao-Fan Wang & Tso-Pang Yao, 2002. "HDAC6 is a microtubule-associated deacetylase," Nature, Nature, vol. 417(6887), pages 455-458, May.
    5. Georg Dietzl & Doris Chen & Frank Schnorrer & Kuan-Chung Su & Yulia Barinova & Michaela Fellner & Beate Gasser & Kaolin Kinsey & Silvia Oppel & Susanne Scheiblauer & Africa Couto & Vincent Marra & Kry, 2007. "A genome-wide transgenic RNAi library for conditional gene inactivation in Drosophila," Nature, Nature, vol. 448(7150), pages 151-156, July.
    Full references (including those not matched with items on IDEAS)

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Charlotte M. François & Thomas Pihl & Marion Dunoyer de Segonzac & Chloé Hérault & Bruno Hudry, 2023. "Metabolic regulation of proteome stability via N-terminal acetylation controls male germline stem cell differentiation and reproduction," Nature Communications, Nature, vol. 14(1), pages 1-18, December.

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. Nour-el-Hana Abbassi & Marcin Jaciuk & David Scherf & Pauline Böhnert & Alexander Rau & Alexander Hammermeister & Michał Rawski & Paulina Indyka & Grzegorz Wazny & Andrzej Chramiec-Głąbik & Dominika D, 2024. "Cryo-EM structures of the human Elongator complex at work," Nature Communications, Nature, vol. 15(1), pages 1-16, December.
    2. Josep J Centelles, 2019. "Microtubule Stabilization by Drugs or Enzymes," Biomedical Journal of Scientific & Technical Research, Biomedical Research Network+, LLC, vol. 22(2), pages 16477-16479, October.
    3. Eyal Rozenfeld & Nadine Ehmann & Julia E. Manoim & Robert J. Kittel & Moshe Parnas, 2023. "Homeostatic synaptic plasticity rescues neural coding reliability," Nature Communications, Nature, vol. 14(1), pages 1-14, December.
    4. Hiroyuki Uechi & Kazuki Fukushima & Ryota Shirasawa & Sayaka Sekine & Erina Kuranaga, 2022. "Inhibition of negative feedback for persistent epithelial cell–cell junction contraction by p21-activated kinase 3," Nature Communications, Nature, vol. 13(1), pages 1-12, December.
    5. Mireia Andreu-Carbó & Cornelia Egoldt & Marie-Claire Velluz & Charlotte Aumeier, 2024. "Microtubule damage shapes the acetylation gradient," Nature Communications, Nature, vol. 15(1), pages 1-14, December.
    6. Patricia González-Rodríguez & Daniel J. Klionsky & Bertrand Joseph, 2022. "Autophagy regulation by RNA alternative splicing and implications in human diseases," Nature Communications, Nature, vol. 13(1), pages 1-17, December.
    7. Michaela Joyce & Federica A. Falconio & Laurence Blackhurst & Lucia Prieto-Godino & Alice S. French & Giorgio F. Gilestro, 2024. "Divergent evolution of sleep in Drosophila species," Nature Communications, Nature, vol. 15(1), pages 1-11, December.
    8. Caroline Dour & Maria Chatzifrangkeskou & Coline Macquart & Maria M. Magiera & Cécile Peccate & Charlène Jouve & Laura Virtanen & Tiina Heliö & Katriina Aalto-Setälä & Silvia Crasto & Bruno Cadot & Dé, 2022. "Actin-microtubule cytoskeletal interplay mediated by MRTF-A/SRF signaling promotes dilated cardiomyopathy caused by LMNA mutations," Nature Communications, Nature, vol. 13(1), pages 1-21, December.
    9. Olga Kubrak & Takashi Koyama & Nadja Ahrentløv & Line Jensen & Alina Malita & Muhammad T. Naseem & Mette Lassen & Stanislav Nagy & Michael J. Texada & Kenneth V. Halberg & Kim Rewitz, 2022. "The gut hormone Allatostatin C/Somatostatin regulates food intake and metabolic homeostasis under nutrient stress," Nature Communications, Nature, vol. 13(1), pages 1-17, December.
    10. Zachary T. Spencer & Victoria H. Ng & Hassina Benchabane & Ghalia Saad Siddiqui & Deepesh Duwadi & Ben Maines & Jamal M. Bryant & Anna Schwarzkopf & Kai Yuan & Sara N. Kassel & Anant Mishra & Ashley P, 2023. "The USP46 deubiquitylase complex increases Wingless/Wnt signaling strength by stabilizing Arrow/LRP6," Nature Communications, Nature, vol. 14(1), pages 1-17, December.
    11. Olga Kubrak & Anne F. Jørgensen & Takashi Koyama & Mette Lassen & Stanislav Nagy & Jacob Hald & Gianluca Mazzoni & Dennis Madsen & Jacob B. Hansen & Martin Røssel Larsen & Michael J. Texada & Jakob L., 2024. "LGR signaling mediates muscle-adipose tissue crosstalk and protects against diet-induced insulin resistance," Nature Communications, Nature, vol. 15(1), pages 1-22, December.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:natcom:v:12:y:2021:i:1:d:10.1038_s41467-021-25786-y. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.