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The insect somatostatin pathway gates vitellogenesis progression during reproductive maturation and the post-mating response

Author

Listed:
  • Chen Zhang

    (School of Life Sciences, Gwangju Institute of Science and Technology (GIST))

  • Anmo J. Kim

    (Hanyang University
    Hanyang University)

  • Crisalesandra Rivera-Perez

    (Department of Fisheries Ecology, Consejo Nacional de Ciencia y Tecnología, Centro de Investigaciones Biológicas del Noroeste)

  • Fernando G. Noriega

    (Florida International University
    University of South Bohemia)

  • Young-Joon Kim

    (School of Life Sciences, Gwangju Institute of Science and Technology (GIST))

Abstract

Vitellogenesis (yolk accumulation) begins upon eclosion and continues through the process of sexual maturation. Upon reaching sexual maturity, vitellogenesis is placed on hold until it is induced again by mating. However, the mechanisms that gate vitellogenesis in response to developmental and reproductive signals remain unclear. Here, we have identified the neuropeptide allatostatin-C (AstC)-producing neurons that gate both the initiation of vitellogenesis that occurs post-eclosion and its re-initiation post-mating. During sexual maturation, the AstC neurons receive excitatory inputs from Sex Peptide Abdominal Ganglion (SAG) neurons. In mature virgin females, high sustained activity of SAG neurons shuts off vitellogenesis via continuous activation of the AstC neurons. Upon mating, however, Sex Peptide inhibits SAG neurons, leading to deactivation of the AstC neurons. As a result, this permits both JH biosynthesis and the progression of vitellogenesis in mated females. Our work has uncovered a central neural circuit that gates the progression of oogenesis.

Suggested Citation

  • Chen Zhang & Anmo J. Kim & Crisalesandra Rivera-Perez & Fernando G. Noriega & Young-Joon Kim, 2022. "The insect somatostatin pathway gates vitellogenesis progression during reproductive maturation and the post-mating response," Nature Communications, Nature, vol. 13(1), pages 1-15, December.
    • Handle: RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-022-28592-2
    DOI: 10.1038/s41467-022-28592-2
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    References listed on IDEAS

    as
    1. Kaiyu Wang & Fei Wang & Nora Forknall & Tansy Yang & Christopher Patrick & Ruchi Parekh & Barry J. Dickson, 2021. "Neural circuit mechanisms of sexual receptivity in Drosophila females," Nature, Nature, vol. 589(7843), pages 577-581, January.
    2. Fei Wang & Kaiyu Wang & Nora Forknall & Christopher Patrick & Tansy Yang & Ruchi Parekh & Davi Bock & Barry J. Dickson, 2020. "Neural circuitry linking mating and egg laying in Drosophila females," Nature, Nature, vol. 579(7797), pages 101-105, March.
    3. Yong-Hoon Jang & Hyo-Seok Chae & Young-Joon Kim, 2017. "Female-specific myoinhibitory peptide neurons regulate mating receptivity in Drosophila melanogaster," Nature Communications, Nature, vol. 8(1), pages 1-12, December.
    4. Nilay Yapici & Young-Joon Kim & Carlos Ribeiro & Barry J. Dickson, 2008. "A receptor that mediates the post-mating switch in Drosophila reproductive behaviour," Nature, Nature, vol. 451(7174), pages 33-37, January.
    5. Olga Kubrak & Takashi Koyama & Nadja Ahrentløv & Line Jensen & Alina Malita & Muhammad T. Naseem & Mette Lassen & Stanislav Nagy & Michael J. Texada & Kenneth V. Halberg & Kim Rewitz, 2022. "The gut hormone Allatostatin C/Somatostatin regulates food intake and metabolic homeostasis under nutrient stress," Nature Communications, Nature, vol. 13(1), pages 1-17, December.
    6. Fumika N. Hamada & Mark Rosenzweig & Kyeongjin Kang & Stefan R. Pulver & Alfredo Ghezzi & Timothy J. Jegla & Paul A. Garrity, 2008. "An internal thermal sensor controlling temperature preference in Drosophila," Nature, Nature, vol. 454(7201), pages 217-220, July.
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    1. Seong-Jin Kim & Kang-Min Lee & Si Hyung Park & Taekyun Yang & Ingyu Song & Fumika Rai & Ryo Hoshino & Minsik Yun & Chen Zhang & Jae-Il Kim & Sunjae Lee & Greg S. B. Suh & Ryusuke Niwa & Zee-Yong Park , 2024. "A sexually transmitted sugar orchestrates reproductive responses to nutritional stress," Nature Communications, Nature, vol. 15(1), pages 1-17, December.

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