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Nutrient-sensing mechanisms and pathways

Author

Listed:
  • Alejo Efeyan

    (Whitehead Institute for Biomedical Research, Nine Cambridge Center
    Massachusetts Institute of Technology
    David H. Koch Institute for Integrative Cancer Research at Massachusetts Institute of Technology
    Broad Institute, Seven Cambridge Center)

  • William C. Comb

    (Whitehead Institute for Biomedical Research, Nine Cambridge Center
    Massachusetts Institute of Technology
    David H. Koch Institute for Integrative Cancer Research at Massachusetts Institute of Technology
    Broad Institute, Seven Cambridge Center)

  • David M. Sabatini

    (Whitehead Institute for Biomedical Research, Nine Cambridge Center
    Massachusetts Institute of Technology
    David H. Koch Institute for Integrative Cancer Research at Massachusetts Institute of Technology
    Broad Institute, Seven Cambridge Center)

Abstract

The ability to sense and respond to fluctuations in environmental nutrient levels is a requisite for life. Nutrient scarcity is a selective pressure that has shaped the evolution of most cellular processes. Different pathways that detect intracellular and extracellular levels of sugars, amino acids, lipids and surrogate metabolites are integrated and coordinated at the organismal level through hormonal signals. During food abundance, nutrient-sensing pathways engage anabolism and storage, whereas scarcity triggers homeostatic mechanisms, such as the mobilization of internal stores through autophagy. Nutrient-sensing pathways are commonly deregulated in human metabolic diseases.

Suggested Citation

  • Alejo Efeyan & William C. Comb & David M. Sabatini, 2015. "Nutrient-sensing mechanisms and pathways," Nature, Nature, vol. 517(7534), pages 302-310, January.
    • Handle: RePEc:nat:nature:v:517:y:2015:i:7534:d:10.1038_nature14190
    DOI: 10.1038/nature14190
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    1. George Rosenberger & Wenxue Li & Mikko Turunen & Jing He & Prem S. Subramaniam & Sergey Pampou & Aaron T. Griffin & Charles Karan & Patrick Kerwin & Diana Murray & Barry Honig & Yansheng Liu & Andrea , 2024. "Network-based elucidation of colon cancer drug resistance mechanisms by phosphoproteomic time-series analysis," Nature Communications, Nature, vol. 15(1), pages 1-27, December.
    2. Joana Silva & Ferhat Alkan & Sofia Ramalho & Goda Snieckute & Stefan Prekovic & Ana Krotenberg Garcia & Santiago Hernández-Pérez & Rob Kammen & Danielle Barnum & Liesbeth Hoekman & Maarten Altelaar & , 2022. "Ribosome impairment regulates intestinal stem cell identity via ZAKɑ activation," Nature Communications, Nature, vol. 13(1), pages 1-12, December.
    3. Nicola Alesi & Elie W. Akl & Damir Khabibullin & Heng-Jia Liu & Anna S. Nidhiry & Emma R. Garner & Harilaos Filippakis & Hilaire C. Lam & Wei Shi & Srinivas R. Viswanathan & Manrico Morroni & Shawn M., 2021. "TSC2 regulates lysosome biogenesis via a non-canonical RAGC and TFEB-dependent mechanism," Nature Communications, Nature, vol. 12(1), pages 1-12, December.
    4. Olga Kubrak & Takashi Koyama & Nadja Ahrentløv & Line Jensen & Alina Malita & Muhammad T. Naseem & Mette Lassen & Stanislav Nagy & Michael J. Texada & Kenneth V. Halberg & Kim Rewitz, 2022. "The gut hormone Allatostatin C/Somatostatin regulates food intake and metabolic homeostasis under nutrient stress," Nature Communications, Nature, vol. 13(1), pages 1-17, December.
    5. E. Havula & S. Ghazanfar & N. Lamichane & D. Francis & K. Hasygar & Y. Liu & L. A. Alton & J. Johnstone & E. J. Needham & T. Pulpitel & T. Clark & H. N. Niranjan & V. Shang & V. Tong & N. Jiwnani & G., 2022. "Genetic variation of macronutrient tolerance in Drosophila melanogaster," Nature Communications, Nature, vol. 13(1), pages 1-16, December.
    6. Tomas Venit & Oscar Sapkota & Wael Said Abdrabou & Palanikumar Loganathan & Renu Pasricha & Syed Raza Mahmood & Nadine Hosny El Said & Shimaa Sherif & Sneha Thomas & Salah Abdelrazig & Shady Amin & Da, 2023. "Positive regulation of oxidative phosphorylation by nuclear myosin 1 protects cells from metabolic reprogramming and tumorigenesis in mice," Nature Communications, Nature, vol. 14(1), pages 1-24, December.
    7. Kibum Kim & Hee Chan Yoo & Byung Gyu Kim & Sulhee Kim & Yulseung Sung & Ina Yoon & Ya Chun Yu & Seung Joon Park & Jong Hyun Kim & Kyungjae Myung & Kwang Yeon Hwang & Sunghoon Kim & Jung Min Han, 2022. "O-GlcNAc modification of leucyl-tRNA synthetase 1 integrates leucine and glucose availability to regulate mTORC1 and the metabolic fate of leucine," Nature Communications, Nature, vol. 13(1), pages 1-19, December.

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