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An internal thermal sensor controlling temperature preference in Drosophila

Author

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  • Fumika N. Hamada

    (National Center for Behavioral Genomics, Volen Center for Complex Systems, Brandeis University MS-008, 415 South Street, Waltham, Massachusetts 02454, USA)

  • Mark Rosenzweig

    (National Center for Behavioral Genomics, Volen Center for Complex Systems, Brandeis University MS-008, 415 South Street, Waltham, Massachusetts 02454, USA)

  • Kyeongjin Kang

    (National Center for Behavioral Genomics, Volen Center for Complex Systems, Brandeis University MS-008, 415 South Street, Waltham, Massachusetts 02454, USA)

  • Stefan R. Pulver

    (National Center for Behavioral Genomics, Volen Center for Complex Systems, Brandeis University MS-008, 415 South Street, Waltham, Massachusetts 02454, USA)

  • Alfredo Ghezzi

    (National Center for Behavioral Genomics, Volen Center for Complex Systems, Brandeis University MS-008, 415 South Street, Waltham, Massachusetts 02454, USA)

  • Timothy J. Jegla

    (The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA)

  • Paul A. Garrity

    (National Center for Behavioral Genomics, Volen Center for Complex Systems, Brandeis University MS-008, 415 South Street, Waltham, Massachusetts 02454, USA)

Abstract

Fruit flies feel the heat In large animals the sensors used to monitor environmental temperature are found at the periphery of the body, and the prevailing wisdom has been that their location in small animals would be the same. For instance it was assumed that insects would sense ambient temperature via their antennae. But a surprise finding in Drosophila has identified the large heat-responsive neurons that detect ambient temperature, and they are located internally, in the brain. The four anterior cell neurons respond to warmth by activating dTrpA1 ion channels, presumably alerting the fly to seek more hospitable climes. These channels are potential targets for the disruption of thermal preference behaviours in insect pests and disease vectors.

Suggested Citation

  • Fumika N. Hamada & Mark Rosenzweig & Kyeongjin Kang & Stefan R. Pulver & Alfredo Ghezzi & Timothy J. Jegla & Paul A. Garrity, 2008. "An internal thermal sensor controlling temperature preference in Drosophila," Nature, Nature, vol. 454(7201), pages 217-220, July.
    • Handle: RePEc:nat:nature:v:454:y:2008:i:7201:d:10.1038_nature07001
    DOI: 10.1038/nature07001
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    Cited by:

    1. Lan Pang & Zhiguo Liu & Jiani Chen & Zhi Dong & Sicong Zhou & Qichao Zhang & Yueqi Lu & Yifeng Sheng & Xuexin Chen & Jianhua Huang, 2022. "Search performance and octopamine neuronal signaling mediate parasitoid induced changes in Drosophila oviposition behavior," Nature Communications, Nature, vol. 13(1), pages 1-18, December.
    2. Chen Zhang & Anmo J. Kim & Crisalesandra Rivera-Perez & Fernando G. Noriega & Young-Joon Kim, 2022. "The insect somatostatin pathway gates vitellogenesis progression during reproductive maturation and the post-mating response," Nature Communications, Nature, vol. 13(1), pages 1-15, December.
    3. Olga Kubrak & Anne F. Jørgensen & Takashi Koyama & Mette Lassen & Stanislav Nagy & Jacob Hald & Gianluca Mazzoni & Dennis Madsen & Jacob B. Hansen & Martin Røssel Larsen & Michael J. Texada & Jakob L., 2024. "LGR signaling mediates muscle-adipose tissue crosstalk and protects against diet-induced insulin resistance," Nature Communications, Nature, vol. 15(1), pages 1-22, December.
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    5. Olga Kubrak & Takashi Koyama & Nadja Ahrentløv & Line Jensen & Alina Malita & Muhammad T. Naseem & Mette Lassen & Stanislav Nagy & Michael J. Texada & Kenneth V. Halberg & Kim Rewitz, 2022. "The gut hormone Allatostatin C/Somatostatin regulates food intake and metabolic homeostasis under nutrient stress," Nature Communications, Nature, vol. 13(1), pages 1-17, December.
    6. Junjun Gao & Song Zhang & Pan Deng & Zhigang Wu & Bruno Lemaitre & Zongzhao Zhai & Zheng Guo, 2024. "Dietary L-Glu sensing by enteroendocrine cells adjusts food intake via modulating gut PYY/NPF secretion," Nature Communications, Nature, vol. 15(1), pages 1-22, December.
    7. Kit D. Longden & Edward M. Rogers & Aljoscha Nern & Heather Dionne & Michael B. Reiser, 2023. "Different spectral sensitivities of ON- and OFF-motion pathways enhance the detection of approaching color objects in Drosophila," Nature Communications, Nature, vol. 14(1), pages 1-22, December.

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