IDEAS home Printed from https://ideas.repec.org/a/nat/natcom/v12y2021i1d10.1038_s41467-021-27201-y.html
   My bibliography  Save this article

Functional convalescent plasma antibodies and pre-infusion titers shape the early severe COVID-19 immune response

Author

Listed:
  • Jonathan D. Herman

    (Ragon Institute of MGH, MIT, and Harvard
    Division of Infectious Disease, Brigham and Women’s Hospital)

  • Chuangqi Wang

    (Massachusetts Institute of Technology)

  • Carolin Loos

    (Ragon Institute of MGH, MIT, and Harvard
    Massachusetts Institute of Technology)

  • Hyunah Yoon

    (Albert Einstein College of Medicine and Montefiore Medical Center)

  • Johanna Rivera

    (Albert Einstein College of Medicine and Montefiore Medical Center
    Albert Einstein College of Medicine)

  • M. Eugenia Dieterle

    (Albert Einstein College of Medicine)

  • Denise Haslwanter

    (Albert Einstein College of Medicine)

  • Rohit K. Jangra

    (Louisiana State University Health Science Center-Shreveport)

  • Robert H. Bortz

    (Albert Einstein College of Medicine)

  • Katharine J. Bar

    (University of Pennsylvania)

  • Boris Julg

    (Ragon Institute of MGH, MIT, and Harvard)

  • Kartik Chandran

    (Albert Einstein College of Medicine)

  • Douglas Lauffenburger

    (Massachusetts Institute of Technology)

  • Liise-anne Pirofski

    (Albert Einstein College of Medicine and Montefiore Medical Center
    Albert Einstein College of Medicine)

  • Galit Alter

    (Ragon Institute of MGH, MIT, and Harvard)

Abstract

Transfer of convalescent plasma (CP) had been proposed early during the SARS-CoV-2 pandemic as an accessible therapy, yet trial results worldwide have been mixed, potentially due to the heterogeneous nature of CP. Here we perform deep profiling of SARS-CoV-2-specific antibody titer, Fc-receptor binding, and Fc-mediated functional assays in CP units, as well as in plasma from hospitalized COVID-19 patients before and after CP administration. The profiling results show that, although all recipients exhibit expanded SARS-CoV-2-specific humoral immune responses, CP units contain more functional antibodies than recipient plasma. Meanwhile, CP functional profiles influence the evolution of recipient humoral immunity in conjuncture with the recipient’s pre-existing SARS-CoV2-specific antibody titers: CP-derived SARS-CoV-2 nucleocapsid-specific antibody functions are associated with muted humoral immune evolution in patients with high titer anti-spike IgG. Our data thus provide insights into the unexpected impact of CP-derived functional anti-spike and anti-nucleocapsid antibodies on the evolution of SARS-CoV-2-specific response following severe infection.

Suggested Citation

  • Jonathan D. Herman & Chuangqi Wang & Carolin Loos & Hyunah Yoon & Johanna Rivera & M. Eugenia Dieterle & Denise Haslwanter & Rohit K. Jangra & Robert H. Bortz & Katharine J. Bar & Boris Julg & Kartik , 2021. "Functional convalescent plasma antibodies and pre-infusion titers shape the early severe COVID-19 immune response," Nature Communications, Nature, vol. 12(1), pages 1-11, December.
    • Handle: RePEc:nat:natcom:v:12:y:2021:i:1:d:10.1038_s41467-021-27201-y
    DOI: 10.1038/s41467-021-27201-y
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/s41467-021-27201-y
    File Function: Abstract
    Download Restriction: no
    File URL: https://libkey.io/10.1038/s41467-021-27201-y?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    References listed on IDEAS

    as
    1. Chuang Guo & Bin Li & Huan Ma & Xiaofang Wang & Pengfei Cai & Qiaoni Yu & Lin Zhu & Liying Jin & Chen Jiang & Jingwen Fang & Qian Liu & Dandan Zong & Wen Zhang & Yichen Lu & Kun Li & Xuyuan Gao & Binq, 2020. "Single-cell analysis of two severe COVID-19 patients reveals a monocyte-associated and tocilizumab-responding cytokine storm," Nature Communications, Nature, vol. 11(1), pages 1-11, December.
    2. Arvind Gharbharan & Carlijn C. E. Jordans & Corine GeurtsvanKessel & Jan G. Hollander & Faiz Karim & Femke P. N. Mollema & Janneke E. Stalenhoef – Schukken & Anthonius Dofferhoff & Inge Ludwig & Adria, 2021. "Effects of potent neutralizing antibodies from convalescent plasma in patients hospitalized for severe SARS-CoV-2 infection," Nature Communications, Nature, vol. 12(1), pages 1-12, December.
    3. World Bank, 2020. "Global Economic Prospects, June 2020," World Bank Publications - Books, The World Bank Group, number 33748.
    4. Hana Lango Allen & Karol Estrada & Guillaume Lettre & Sonja I. Berndt & Michael N. Weedon & Fernando Rivadeneira & Cristen J. Willer & Anne U. Jackson & Sailaja Vedantam & Soumya Raychaudhuri & Teresa, 2010. "Hundreds of variants clustered in genomic loci and biological pathways affect human height," Nature, Nature, vol. 467(7317), pages 832-838, October.
    Full references (including those not matched with items on IDEAS)

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. X. Tong & R. P. McNamara & M. J. Avendaño & E. F. Serrano & T. García-Salum & C. Pardo-Roa & H. L. Bertera & T. M. Chicz & J. Levican & E. Poblete & E. Salinas & A. Muñoz & A. Riquelme & G. Alter & R., 2023. "Waning and boosting of antibody Fc-effector functions upon SARS-CoV-2 vaccination," Nature Communications, Nature, vol. 14(1), pages 1-15, December.

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. Gutiérrez-Romero, Roxana & Ahamed, Mostak, 2021. "COVID-19 response needs to broaden financial inclusion to curb the rise in poverty," World Development, Elsevier, vol. 138(C).
    2. Hadzi-Vaskov Metodij & Pienknagura Samuel & Ricci Luca Antonio, 2023. "The Macroeconomic Impact of Social Unrest," The B.E. Journal of Macroeconomics, De Gruyter, vol. 23(2), pages 917-958, June.
    3. Isaac K. Ofori, 2021. "Towards Building Shared Prosperity in Sub-Saharan Africa: How Does the Effect of Economic Integration Compare to Social Equity Policies?," Working Papers of the African Governance and Development Institute. 21/045, African Governance and Development Institute..
    4. Orietta Nicolis & Jean Paul Maidana & Fabian Contreras & Danilo Leal, 2024. "Analyzing the Impact of COVID-19 on Economic Sustainability: A Clustering Approach," Sustainability, MDPI, vol. 16(4), pages 1-30, February.
    5. Adian,Ikmal & Doumbia,Djeneba & Gregory,Neil & Ragoussis,Alexandros & Reddy,Aarti & Timmis,Jonathan David, 2020. "Small and Medium Enterprises in the Pandemic : Impact, Responses and the Role of Development Finance," Policy Research Working Paper Series 9414, The World Bank.
    6. González, Marta Ramos & Ureña, Antonio Partal & Fernández-Aguado, Pilar Gómez, 2023. "Forecasting for regulatory credit loss derived from the COVID-19 pandemic: A machine learning approach," Research in International Business and Finance, Elsevier, vol. 64(C).
    7. Quibria, M.G., 2020. "Poverty and Policy in the Developing World: Before and After the Pandemic," MPRA Paper 104240, University Library of Munich, Germany, revised 15 Oct 2020.
    8. Ofori, Isaac K. & Armah, Mark K. & Taale, Francis & Ofori, Pamela E., 2021. "Addressing the Severity and Intensity of Poverty in Sub-Saharan Africa: How Relevant is the ICT and Financial Development Pathway?," EconStor Open Access Articles and Book Chapters, ZBW - Leibniz Information Centre for Economics, issue forthcomi.
    9. Ștefan Cristian Gherghina & Daniel Ștefan Armeanu & Camelia Cătălina Joldeș, 2020. "Stock Market Reactions to COVID-19 Pandemic Outbreak: Quantitative Evidence from ARDL Bounds Tests and Granger Causality Analysis," IJERPH, MDPI, vol. 17(18), pages 1-35, September.
    10. Lingli Yu & Ling Yang, 2024. "News media in crisis: a sentiment and emotion analysis of US news articles on unemployment in the COVID-19 pandemic," Palgrave Communications, Palgrave Macmillan, vol. 11(1), pages 1-9, December.
    11. Marinov, Eduard, 2020. "Новият Шок Covid 19 – Въздействие Върху Международната Търговия На Глобално И Национално Ниво [The new shock COVID 19 - impact on international trade on a global and national level]," MPRA Paper 110921, University Library of Munich, Germany.
    12. Katherine Carbeck & Peter Arcese & Irby Lovette & Christin Pruett & Kevin Winker & Jennifer Walsh, 2023. "Candidate genes under selection in song sparrows co-vary with climate and body mass in support of Bergmann’s Rule," Nature Communications, Nature, vol. 14(1), pages 1-10, December.
    13. Osman Taylan & Abdulaziz S. Alkabaa & Mustafa Tahsin Yılmaz, 2022. "Impact of COVID-19 on G20 countries: analysis of economic recession using data mining approaches," Financial Innovation, Springer;Southwestern University of Finance and Economics, vol. 8(1), pages 1-30, December.
    14. Abel Brodeur & David Gray & Anik Islam & Suraiya Bhuiyan, 2021. "A literature review of the economics of COVID‐19," Journal of Economic Surveys, Wiley Blackwell, vol. 35(4), pages 1007-1044, September.
    15. Liu, Li-Jing & Yao, Yun-Fei & Liang, Qiao-Mei & Qian, Xiang-Yan & Xu, Chun-Lei & Wei, Si-Yi & Creutzig, Felix & Wei, Yi-Ming, 2021. "Combining economic recovery with climate change mitigation: A global evaluation of financial instruments," Economic Analysis and Policy, Elsevier, vol. 72(C), pages 438-453.
    16. Abdoul’ Ganiou Mijiyawa & Djoulassi K. Oloufade, 2023. "Effect of Remittance Inflows on External Debt in Developing Countries," Open Economies Review, Springer, vol. 34(2), pages 437-470, April.
    17. Isaac K. Ofori & Mark K. Armah & Emmanuel E. Asmah, 2021. "Towards the Reversal of Poverty and Income Inequality Setbacks Due to COVID-19: The Role of Globalisation and Resource Allocation," Working Papers 21/043, European Xtramile Centre of African Studies (EXCAS).
    18. Francisco Ceballos & Manuel A. Hernandez & Cynthia Paz, 2021. "Short‐term impacts of COVID‐19 on food security and nutrition in rural Guatemala: Phone‐based farm household survey evidence," Agricultural Economics, International Association of Agricultural Economists, vol. 52(3), pages 477-494, May.
    19. Daud, Siti Nurazira Mohd & Ahmad, Abd Halim, 2023. "Financial inclusion, economic growth and the role of digital technology," Finance Research Letters, Elsevier, vol. 53(C).
    20. Yothin Jinjarak & Ilan Noy & Quy Ta, 2022. "Pandemics and Economic Growth: Evidence from the 1968 H3N2 Influenza," Economics of Disasters and Climate Change, Springer, vol. 6(1), pages 73-93, March.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:natcom:v:12:y:2021:i:1:d:10.1038_s41467-021-27201-y. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.