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Effects of potent neutralizing antibodies from convalescent plasma in patients hospitalized for severe SARS-CoV-2 infection

Author

Listed:
  • Arvind Gharbharan

    (University Medical Center)

  • Carlijn C. E. Jordans

    (University Medical Center)

  • Corine GeurtsvanKessel

    (University Medical Center)

  • Jan G. Hollander

    (Maasstad Hospital)

  • Faiz Karim

    (Groene Hart Hospital)

  • Femke P. N. Mollema

    (Haaglanden Medical Center)

  • Janneke E. Stalenhoef – Schukken

    (OLVG Hospital)

  • Anthonius Dofferhoff

    (Canisius Wilhelmina Hospital)

  • Inge Ludwig

    (Bernhoven Hospital)

  • Adrianus Koster

    (Viecuri Medical Center)

  • Robert-Jan Hassing

    (Rijnstate Hospital)

  • Jeannet C. Bos

    (Reinier de Graaf Gasthuis)

  • Geert R. Pottelberge

    (ZorgSaam Hospital)

  • Imro N. Vlasveld

    (Martini Hospital)

  • Heidi S. M. Ammerlaan

    (Catharina Hospital)

  • Elena M. Leeuwen – Segarceanu

    (Sint Antonius Hospital)

  • Jelle Miedema

    (University Medical Center)

  • Menno Eerden

    (University Medical Center)

  • Thijs J. Schrama

    (University Medical Center)

  • Grigorios Papageorgiou

    (University Medical Center)

  • Peter Boekhorst

    (University Medical Center)

  • Francis H. Swaneveld

    (Unit of Transfusion Medicine, Sanquin Blood Supply)

  • Yvonne M. Mueller

    (University Medical Center)

  • Marco W. J. Schreurs

    (University Medical Center)

  • Jeroen J. A. Kampen

    (University Medical Center)

  • Barry Rockx

    (University Medical Center)

  • Nisreen M. A. Okba

    (University Medical Center)

  • Peter D. Katsikis

    (University Medical Center)

  • Marion P. G. Koopmans

    (University Medical Center)

  • Bart L. Haagmans

    (University Medical Center)

  • Casper Rokx

    (University Medical Center)

  • Bart J. A. Rijnders

    (University Medical Center)

Abstract

In a randomized clinical trial of 86 hospitalized COVID-19 patients comparing standard care to treatment with 300mL convalescent plasma containing high titers of neutralizing SARS-CoV-2 antibodies, no overall clinical benefit was observed. Using a comprehensive translational approach, we unravel the virological and immunological responses following treatment to disentangle which COVID-19 patients may benefit and should be the focus of future studies. Convalescent plasma is safe, does not improve survival, has no effect on the disease course, nor does plasma enhance viral clearance in the respiratory tract, influence SARS-CoV-2 antibody development or serum proinflammatory cytokines levels. Here, we show that the vast majority of patients already had potent neutralizing SARS-CoV-2 antibodies at hospital admission and with comparable titers to carefully selected plasma donors. This resulted in the decision to terminate the trial prematurely. Treatment with convalescent plasma should be studied early in the disease course or at least preceding autologous humoral response development.

Suggested Citation

  • Arvind Gharbharan & Carlijn C. E. Jordans & Corine GeurtsvanKessel & Jan G. Hollander & Faiz Karim & Femke P. N. Mollema & Janneke E. Stalenhoef – Schukken & Anthonius Dofferhoff & Inge Ludwig & Adria, 2021. "Effects of potent neutralizing antibodies from convalescent plasma in patients hospitalized for severe SARS-CoV-2 infection," Nature Communications, Nature, vol. 12(1), pages 1-12, December.
    • Handle: RePEc:nat:natcom:v:12:y:2021:i:1:d:10.1038_s41467-021-23469-2
    DOI: 10.1038/s41467-021-23469-2
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    Cited by:

    1. Jonathan D. Herman & Chuangqi Wang & Carolin Loos & Hyunah Yoon & Johanna Rivera & M. Eugenia Dieterle & Denise Haslwanter & Rohit K. Jangra & Robert H. Bortz & Katharine J. Bar & Boris Julg & Kartik , 2021. "Functional convalescent plasma antibodies and pre-infusion titers shape the early severe COVID-19 immune response," Nature Communications, Nature, vol. 12(1), pages 1-11, December.
    2. Yvonne M. Mueller & Thijs J. Schrama & Rik Ruijten & Marco W. J. Schreurs & Dwin G. B. Grashof & Harmen J. G. van de Werken & Giovanna Jona Lasinio & Daniel Álvarez-Sierra & Caoimhe H. Kiernan & Melis, 2022. "Stratification of hospitalized COVID-19 patients into clinical severity progression groups by immuno-phenotyping and machine learning," Nature Communications, Nature, vol. 13(1), pages 1-13, December.
    3. Pere Millat-Martinez & Arvind Gharbharan & Andrea Alemany & Casper Rokx & Corine Geurtsvankessel & Grigorios Papageorgiou & Nan Geloven & Carlijn Jordans & Geert Groeneveld & Francis Swaneveld & Ellen, 2022. "Prospective individual patient data meta-analysis of two randomized trials on convalescent plasma for COVID-19 outpatients," Nature Communications, Nature, vol. 13(1), pages 1-9, December.

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