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Prospective individual patient data meta-analysis of two randomized trials on convalescent plasma for COVID-19 outpatients

Author

Listed:
  • Pere Millat-Martinez

    (Fight AIDS and Infectious Diseases Foundation
    Universitat de Barcelona)

  • Arvind Gharbharan

    (University Medical Center)

  • Andrea Alemany

    (Fight AIDS and Infectious Diseases Foundation
    Hospital Universitari Germans Trias i Pujol
    Facultat de Medicina-Universitat de Barcelona)

  • Casper Rokx

    (University Medical Center)

  • Corine Geurtsvankessel

    (Erasmus MC)

  • Grigorios Papageorgiou

    (University Medical Center)

  • Nan Geloven

    (Leiden University Medical Center)

  • Carlijn Jordans

    (University Medical Center)

  • Geert Groeneveld

    (Leiden University Medical Center)

  • Francis Swaneveld

    (Sanquin Blood Supply)

  • Ellen Schoot

    (Sanquin Research)

  • Marc Corbacho-Monné

    (Fight AIDS and Infectious Diseases Foundation
    Facultat de Medicina-Universitat de Barcelona
    Hospital Universitari Parc Taulí I3PT)

  • Dan Ouchi

    (Fight AIDS and Infectious Diseases Foundation
    Universitat Autònoma de Barcelona)

  • Francini Piccolo Ferreira

    (Bioclever-CRO)

  • Pierre Malchair

    (L’Hospitalet de LLobregat)

  • Sebastian Videla

    (Fight AIDS and Infectious Diseases Foundation
    L’Hospitalet de Llobregat
    L’Hospitalet de Llobregat)

  • Vanesa García García

    (L’Hospitalet de LLobregat)

  • Anna Ruiz-Comellas

    (Fundació Institut Universitari per a la recerca a l’Atenció Primària de Salut Jordi Gol i Gurina
    Institut Català de la Salut
    Universitat de Vic—Universitat Central de Catalunya (UVIC-UCC))

  • Anna Ramírez-Morros

    (Fundació Institut Universitari per a la recerca a l’Atenció Primària de Salut Jordi Gol i Gurina)

  • Joana Rodriguez Codina

    (Hospital de Berga)

  • Rosa Amado Simon

    (Hospital de Berga)

  • Joan-Ramon Grifols

    (Hospital Universitari Germans Trias i Pujol
    Blood Bank Department—Banc de Sang i Teixits (BST))

  • Julian Blanco

    (Germans Trias i Pujol Research Institute (IGTP))

  • Ignacio Blanco

    (Hospital Universitari Germans Trias i Pujol
    Institut Català de la Salut)

  • Jordi Ara

    (Hospital Universitari Germans Trias i Pujol
    Institut Català de la Salut)

  • Quique Bassat

    (Universitat de Barcelona
    Centro de Investigação em Saúde de Manhiça (CISM)
    ICREA
    Universitat de Barcelona)

  • Bonaventura Clotet

    (Fight AIDS and Infectious Diseases Foundation
    Hospital Universitari Germans Trias i Pujol
    Universitat de Vic—Universitat Central de Catalunya (UVIC-UCC)
    Germans Trias i Pujol Research Institute (IGTP))

  • Bàrbara Baro

    (Universitat de Barcelona)

  • Andrea Troxel

    (NYU Grossman School of Medicine)

  • Jaap Jan Zwaginga

    (Leiden University Medical Centre
    Sanquin Blood Supply)

  • Oriol Mitjà

    (Fight AIDS and Infectious Diseases Foundation
    Hospital Universitari Germans Trias i Pujol
    Universitat de Vic—Universitat Central de Catalunya (UVIC-UCC)
    Lihir Medical Centre—InternationalSOS)

  • Bart J. A. Rijnders

    (University Medical Center)

Abstract

Data on convalescent plasma (CP) treatment in COVID-19 outpatients are scarce. We aimed to assess whether CP administered during the first week of symptoms reduced the disease progression or risk of hospitalization of outpatients. Two multicenter, double-blind randomized trials (NCT04621123, NCT04589949) were merged with data pooling starting when

Suggested Citation

  • Pere Millat-Martinez & Arvind Gharbharan & Andrea Alemany & Casper Rokx & Corine Geurtsvankessel & Grigorios Papageorgiou & Nan Geloven & Carlijn Jordans & Geert Groeneveld & Francis Swaneveld & Ellen, 2022. "Prospective individual patient data meta-analysis of two randomized trials on convalescent plasma for COVID-19 outpatients," Nature Communications, Nature, vol. 13(1), pages 1-9, December.
    • Handle: RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-022-29911-3
    DOI: 10.1038/s41467-022-29911-3
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    References listed on IDEAS

    as
    1. Arvind Gharbharan & Carlijn C. E. Jordans & Corine GeurtsvanKessel & Jan G. Hollander & Faiz Karim & Femke P. N. Mollema & Janneke E. Stalenhoef – Schukken & Anthonius Dofferhoff & Inge Ludwig & Adria, 2021. "Effects of potent neutralizing antibodies from convalescent plasma in patients hospitalized for severe SARS-CoV-2 infection," Nature Communications, Nature, vol. 12(1), pages 1-12, December.
    Full references (including those not matched with items on IDEAS)

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